LIFR_HUMAN - 1097 amino acids
Fungi
Home
Leukemia
LIFR_HUMAN
ABL1_HUMAN
AF9_HUMAN
ARI5B_HUMAN
ATM_HUMAN
BCR_HUMAN
CBL_HUMAN
CEBPA_HUMAN
DNM3A_HUMAN
ETV6_HUMAN
FLT3_HUMAN
FLVC1_HUMAN
JAK2_HUMAN
KAT6A_HUMAN
KIT_HUMAN
KMT2A_HUMAN
LIF_HUMAN
MCL1_HUMAN
MTG8R_HUMAN
NPM_HUMAN
NU214_HUMAN
NUP98_HUMAN
PML_HUMAN
PTN11_HUMAN
RUNX1_HUMAN
S20A1_HUMAN
SETBP_HUMAN
TAL1_HUMAN
TET2_HUMAN
ZBT16_HUMAN
Fungi
All
Cancer
Human
HumanVirus
Leukemia
Viruses
X
NC
CN
Max NC = 44
Total NC = 1362/2586
NC X-axis shows number of BLAST hits for
each of the NC sequences along the Y-axis
Max CN = 82
Total CN = 1224/2586
CN X-axis shows number of BLAST hits for
each of the CN sequences along the Y-axis
Seq1 = 1
Seq2 = 5
Seq3 = 11
Seq4 = 1
Seq5 = 5
Seq6 = 9
Seq7 = 1
Seq8 = 1
Seq9 = 2
Seq10 = 7
Seq11 = 6
Seq12 = 8
Seq13 = 14
Seq14 = 13
Seq15 = 4
Seq16 = 14
Seq17 = 2
Seq18 = 1
Seq20 = 2
Seq21 = 6
Seq22 = 5
Seq23 = 10
Seq24 = 1
Seq27 = 6
Seq28 = 3
Seq29 = 3
Seq30 = 2
Seq31 = 1
Seq32 = 14
Seq33 = 13
Seq35 = 7
Seq39 = 2
Seq40 = 27
Seq41 = 35
Seq42 = 1
Seq43 = 5
Seq44 = 3
Seq45 = 12
Seq46 = 8
Seq47 = 16
Seq48 = 7
Seq49 = 10
Seq50 = 10
Seq51 = 2
Seq52 = 4
Seq54 = 7
Seq55 = 1
Seq57 = 17
Seq58 = 18
Seq59 = 10
Seq60 = 1
Seq62 = 1
Seq63 = 2
Seq64 = 3
Seq65 = 5
Seq66 = 6
Seq67 = 9
Seq68 = 5
Seq69 = 9
Seq70 = 15
Seq71 = 15
Seq72 = 20
Seq73 = 4
Seq75 = 6
Seq76 = 3
Seq77 = 1
Seq78 = 4
Seq80 = 6
Seq81 = 2
Seq82 = 12
Seq83 = 6
Seq85 = 1
Seq86 = 3
Seq87 = 8
Seq88 = 3
Seq90 = 3
Seq91 = 40
Seq92 = 1
Seq93 = 5
Seq97 = 3
Seq98 = 2
Seq99 = 2
Seq100 = 11
Seq101 = 4
Seq102 = 1
Seq103 = 20
Seq104 = 44
Seq105 = 3
Seq107 = 2
Seq108 = 22
Seq109 = 16
Seq110 = 12
Seq111 = 11
Seq112 = 5
Seq113 = 3
Seq114 = 5
Seq115 = 3
Seq117 = 5
Seq118 = 13
Seq119 = 2
Seq120 = 7
Seq123 = 2
Seq125 = 1
Seq126 = 9
Seq127 = 2
Seq128 = 3
Seq129 = 26
Seq130 = 33
Seq131 = 7
Seq132 = 19
Seq133 = 7
Seq134 = 6
Seq135 = 21
Seq136 = 2
Seq138 = 7
Seq139 = 5
Seq140 = 8
Seq141 = 18
Seq142 = 2
Seq143 = 1
Seq144 = 7
Seq145 = 4
Seq146 = 6
Seq148 = 5
Seq149 = 33
Seq150 = 37
Seq151 = 9
Seq152 = 9
Seq153 = 9
Seq155 = 1
Seq156 = 1
Seq157 = 3
Seq158 = 2
Seq160 = 4
Seq161 = 3
Seq162 = 24
Seq163 = 5
Seq164 = 9
Seq166 = 2
Seq171 = 6
Seq172 = 10
Seq173 = 17
Seq174 = 8
Seq175 = 18
Seq176 = 3
Seq179 = 1
Seq180 = 4
Seq181 = 7
Seq182 = 8
Seq184 = 2
Seq186 = 2
Seq187 = 3
Seq188 = 6
Seq189 = 15
Seq190 = 5
Seq191 = 8
Seq192 = 2
Seq194 = 1
Seq196 = 2
Seq197 = 3
Seq198 = 1
Seq199 = 6
Seq200 = 11
Seq201 = 13
Seq203 = 1
Seq204 = 1
Seq205 = 4
Seq206 = 1
Seq207 = 2
Seq208 = 8
Seq209 = 2
Seq210 = 1
Seq212 = 1
Seq213 = 2
Seq214 = 13
Seq215 = 4
Seq216 = 14
Seq217 = 16
Seq218 = 10
SeqR1 = 3
SeqR2 = 5
SeqR3 = 12
SeqR4 = 1
SeqR5 = 3
SeqR6 = 3
SeqR7 = 2
SeqR10 = 4
SeqR11 = 4
SeqR12 = 9
SeqR13 = 18
SeqR14 = 7
SeqR15 = 2
SeqR16 = 6
SeqR17 = 8
SeqR18 = 2
SeqR19 = 2
SeqR21 = 8
SeqR22 = 7
SeqR23 = 5
SeqR24 = 1
SeqR27 = 5
SeqR28 = 4
SeqR31 = 8
SeqR32 = 12
SeqR33 = 4
SeqR34 = 3
SeqR35 = 4
SeqR36 = 1
SeqR37 = 2
SeqR38 = 1
SeqR40 = 30
SeqR41 = 25
SeqR42 = 2
SeqR43 = 9
SeqR44 = 14
SeqR45 = 6
SeqR46 = 8
SeqR47 = 17
SeqR48 = 5
SeqR49 = 6
SeqR50 = 7
SeqR51 = 5
SeqR52 = 2
SeqR53 = 1
SeqR54 = 5
SeqR56 = 1
SeqR57 = 14
SeqR58 = 10
SeqR59 = 2
SeqR63 = 5
SeqR64 = 6
SeqR65 = 2
SeqR66 = 6
SeqR67 = 6
SeqR68 = 4
SeqR69 = 10
SeqR70 = 20
SeqR71 = 10
SeqR72 = 2
SeqR73 = 12
SeqR74 = 1
SeqR75 = 2
SeqR76 = 1
SeqR77 = 1
SeqR78 = 1
SeqR79 = 3
SeqR80 = 4
SeqR81 = 14
SeqR82 = 9
SeqR83 = 7
SeqR84 = 1
SeqR86 = 10
SeqR87 = 10
SeqR88 = 9
SeqR89 = 1
SeqR90 = 1
SeqR91 = 16
SeqR92 = 5
SeqR93 = 3
SeqR96 = 1
SeqR97 = 3
SeqR99 = 13
SeqR100 = 8
SeqR101 = 3
SeqR102 = 4
SeqR103 = 15
SeqR104 = 32
SeqR105 = 12
SeqR108 = 18
SeqR109 = 17
SeqR110 = 3
SeqR111 = 5
SeqR112 = 8
SeqR113 = 1
SeqR114 = 16
SeqR115 = 2
SeqR117 = 1
SeqR118 = 2
SeqR119 = 1
SeqR120 = 2
SeqR121 = 1
SeqR123 = 1
SeqR126 = 2
SeqR128 = 7
SeqR129 = 13
SeqR130 = 25
SeqR131 = 9
SeqR132 = 13
SeqR133 = 3
SeqR134 = 20
SeqR135 = 52
SeqR138 = 14
SeqR139 = 8
SeqR140 = 8
SeqR141 = 6
SeqR142 = 1
SeqR143 = 4
SeqR144 = 5
SeqR145 = 3
SeqR146 = 2
SeqR149 = 82
SeqR150 = 4
SeqR151 = 1
SeqR152 = 9
SeqR153 = 16
SeqR154 = 1
SeqR157 = 1
SeqR160 = 2
SeqR161 = 9
SeqR162 = 1
SeqR163 = 2
SeqR164 = 5
SeqR165 = 10
SeqR166 = 4
SeqR169 = 1
SeqR170 = 1
SeqR171 = 1
SeqR172 = 5
SeqR173 = 6
SeqR174 = 10
SeqR175 = 16
SeqR176 = 2
SeqR178 = 2
SeqR180 = 2
SeqR181 = 8
SeqR182 = 1
SeqR183 = 4
SeqR184 = 4
SeqR185 = 3
SeqR186 = 2
SeqR187 = 1
SeqR188 = 1
SeqR189 = 10
SeqR190 = 11
SeqR191 = 5
SeqR192 = 5
SeqR193 = 3
SeqR194 = 1
SeqR196 = 1
SeqR197 = 3
SeqR198 = 3
SeqR199 = 4
SeqR200 = 2
SeqR201 = 10
SeqR202 = 1
SeqR204 = 2
SeqR205 = 3
SeqR206 = 3
SeqR207 = 6
SeqR208 = 17
SeqR209 = 2
SeqR211 = 5
SeqR212 = 2
SeqR213 = 1
SeqR215 = 3
SeqR216 = 4
SeqR217 = 17
SeqR218 = 12
1 MMDIYVCLKR 1
2 VCLKRPSWMV 5
3 PSWMVDNKRM 11
4 DNKRMRTASN 1
5 RTASNFQWLL 5
6 FQWLLSTFIL 9
7 STFILLYLMN 1
8 LYLMNQVNSQ 1
9 QVNSQKKGAP 2
10 KKGAPHDLKC 7
11 HDLKCVTNNL 6
12 VTNNLQVWNC 8
13 QVWNCSWKAP 14
14 SWKAPSGTGR 13
15 SGTGRGTDYE 4
16 GTDYEVCIEN 14
17 VCIENRSRSC 2
18 RSRSCYQLEK 1
19 YQLEKTSIKI 0
20 TSIKIPALSH 2
21 PALSHGDYEI 6
22 GDYEITINSL 5
23 TINSLHDFGS 10
24 HDFGSSTSKF 1
25 STSKFTLNEQ 0
26 TLNEQNVSLI 0
27 NVSLIPDTPE 6
28 PDTPEILNLS 3
29 ILNLSADFST 3
30 ADFSTSTLYL 2
31 STLYLKWNDR 1
32 KWNDRGSVFP 14
33 GSVFPHRSNV 13
34 HRSNVIWEIK 0
35 IWEIKVLRKE 7
36 VLRKESMELV 0
37 SMELVKLVTH 0
38 KLVTHNTTLN 0
39 NTTLNGKDTL 2
40 GKDTLHHWSW 27
41 HHWSWASDMP 35
42 ASDMPLECAI 1
43 LECAIHFVEI 5
44 HFVEIRCYID 3
45 RCYIDNLHFS 12
46 NLHFSGLEEW 8
47 GLEEWSDWSP 16
48 SDWSPVKNIS 7
49 VKNISWIPDS 10
50 WIPDSQTKVF 10
51 QTKVFPQDKV 2
52 PQDKVILVGS 4
53 ILVGSDITFC 0
54 DITFCCVSQE 7
55 CVSQEKVLSA 1
56 KVLSALIGHT 0
57 LIGHTNCPLI 17
58 NCPLIHLDGE 18
59 HLDGENVAIK 10
60 NVAIKIRNIS 1
61 IRNISVSASS 0
62 VSASSGTNVV 1
63 GTNVVFTTED 2
64 FTTEDNIFGT 3
65 NIFGTVIFAG 5
66 VIFAGYPPDT 6
67 YPPDTPQQLN 9
68 PQQLNCETHD 5
69 CETHDLKEII 9
70 LKEIICSWNP 15
71 CSWNPGRVTA 15
72 GRVTALVGPR 20
73 LVGPRATSYT 4
74 ATSYTLVESF 0
75 LVESFSGKYV 6
76 SGKYVRLKRA 3
77 RLKRAEAPTN 1
78 EAPTNESYQL 4
79 ESYQLLFQML 0
80 LFQMLPNQEI 6
81 PNQEIYNFTL 2
82 YNFTLNAHNP 12
83 NAHNPLGRSQ 6
84 LGRSQSTILV 0
85 STILVNITEK 1
86 NITEKVYPHT 3
87 VYPHTPTSFK 8
88 PTSFKVKDIN 3
89 VKDINSTAVK 0
90 STAVKLSWHL 3
91 LSWHLPGNFA 40
92 PGNFAKINFL 1
93 KINFLCEIEI 5
94 CEIEIKKSNS 0
95 KKSNSVQEQR 0
96 VQEQRNVTIK 0
97 NVTIKGVENS 3
98 GVENSSYLVA 2
99 SYLVALDKLN 2
100 LDKLNPYTLY 11
101 PYTLYTFRIR 4
102 TFRIRCSTET 1
103 CSTETFWKWS 20
104 FWKWSKWSNK 44
105 KWSNKKQHLT 3
106 KQHLTTEASP 0
107 TEASPSKGPD 2
108 SKGPDTWREW 22
109 TWREWSSDGK 16
110 SSDGKNLIIY 12
111 NLIIYWKPLP 11
112 WKPLPINEAN 5
113 INEANGKILS 3
114 GKILSYNVSC 5
115 YNVSCSSDEE 3
116 SSDEETQSLS 0
117 TQSLSEIPDP 5
118 EIPDPQHKAE 13
119 QHKAEIRLDK 2
120 IRLDKNDYII 7
121 NDYIISVVAK 0
122 SVVAKNSVGS 0
123 NSVGSSPPSK 2
124 SPPSKIASME 0
125 IASMEIPNDD 1
126 IPNDDLKIEQ 9
127 LKIEQVVGMG 2
128 VVGMGKGILL 3
129 KGILLTWHYD 26
130 TWHYDPNMTC 33
131 PNMTCDYVIK 7
132 DYVIKWCNSS 19
133 WCNSSRSEPC 7
134 RSEPCLMDWR 6
135 LMDWRKVPSN 21
136 KVPSNSTETV 2
137 STETVIESDE 0
138 IESDEFRPGI 7
139 FRPGIRYNFF 5
140 RYNFFLYGCR 8
141 LYGCRNQGYQ 18
142 NQGYQLLRSM 2
143 LLRSMIGYIE 1
144 IGYIEELAPI 7
145 ELAPIVAPNF 4
146 VAPNFTVEDT 6
147 TVEDTSADSI 0
148 SADSILVKWE 5
149 LVKWEDIPVE 33
150 DIPVEELRGF 37
151 ELRGFLRGYL 9
152 LRGYLFYFGK 9
153 FYFGKGERDT 9
154 GERDTSKMRV 0
155 SKMRVLESGR 1
156 LESGRSDIKV 1
157 SDIKVKNITD 3
158 KNITDISQKT 2
159 ISQKTLRIAD 0
160 LRIADLQGKT 4
161 LQGKTSYHLV 3
162 SYHLVLRAYT 24
163 LRAYTDGGVG 5
164 DGGVGPEKSM 9
165 PEKSMYVVTK 0
166 YVVTKENSVG 2
167 ENSVGLIIAI 0
168 LIIAILIPVA 0
169 LIPVAVAVIV 0
170 VAVIVGVVTS 0
171 GVVTSILCYR 6
172 ILCYRKREWI 10
173 KREWIKETFY 17
174 KETFYPDIPN 8
175 PDIPNPENCK 18
176 PENCKALQFQ 3
177 ALQFQKSVCE 0
178 KSVCEGSSAL 0
179 GSSALKTLEM 1
180 KTLEMNPCTP 4
181 NPCTPNNVEV 7
182 NNVEVLETRS 8
183 LETRSAFPKI 0
184 AFPKIEDTEI 2
185 EDTEIISPVA 0
186 ISPVAERPED 2
187 ERPEDRSDAE 3
188 RSDAEPENHV 6
189 PENHVVVSYC 15
190 VVSYCPPIIE 5
191 PPIIEEEIPN 8
192 EEIPNPAADE 2
193 PAADEAGGTA 0
194 AGGTAQVIYI 1
195 QVIYIDVQSM 0
196 DVQSMYQPQA 2
197 YQPQAKPEEE 3
198 KPEEEQENDP 1
199 QENDPVGGAG 6
200 VGGAGYKPQM 11
201 YKPQMHLPIN 13
202 HLPINSTVED 0
203 STVEDIAAEE 1
204 IAAEEDLDKT 1
205 DLDKTAGYRP 4
206 AGYRPQANVN 1
207 QANVNTWNLV 2
208 TWNLVSPDSP 8
209 SPDSPRSIDS 2
210 RSIDSNSEIV 1
211 NSEIVSFGSP 0
212 SFGSPCSINS 1
213 CSINSRQFLI 2
214 RQFLIPPKDE 13
215 PPKDEDSPKS 4
216 DSPKSNGGGW 14
217 NGGGWSFTNF 16
218 SFTNFFQNKPND 10
1 RKLCVYIDMM 3
2 VMWSPRKLCV 5
3 MRKNDVMWSP 12
4 NSATRMRKND 1
5 LLWQFNSATR 3
6 LIFTSLLWQF 3
7 NMLYLLIFTS 2
8 QSNVQNMLYL 0
9 PAGKKQSNVQ 0
10 CKLDHPAGKK 4
11 LNNTVCKLDH 4
12 CNWVQLNNTV 9
13 PAKWSCNWVQ 18
14 RGTGSPAKWS 7
15 EYDTGRGTGS 2
16 NEICVEYDTG 6
17 CSRSRNEICV 8
18 KELQYCSRSR 2
19 IKISTKELQY 2
20 HSLAPIKIST 0
21 IEYDGHSLAP 8
22 LSNITIEYDG 7
23 SGFDHLSNIT 5
24 FKSTSSGFDH 1
25 QENLTFKSTS 0
26 ILSVNQENLT 0
27 EPTDPILSVN 5
28 SLNLIEPTDP 4
29 TSFDASLNLI 0
30 LYLTSTSFDA 0
31 RDNWKLYLTS 8
32 PFVSGRDNWK 12
33 VNSRHPFVSG 4
34 KIEWIVNSRH 3
35 EKRLVKIEWI 4
36 VLEMSEKRLV 1
37 HTVLKVLEMS 2
38 NLTTNHTVLK 1
39 LTDKGNLTTN 0
40 WSWHHLTDKG 30
41 PMDSAWSWHH 25
42 IACELPMDSA 2
43 IEVFHIACEL 9
44 DIYCRIEVFH 14
45 SFHLNDIYCR 6
46 WEELGSFHLN 8
47 PSWDSWEELG 17
48 SINKVPSWDS 5
49 SDPIWSINKV 6
50 FVKTQSDPIW 7
51 VKDQPFVKTQ 5
52 SGVLIVKDQP 2
53 CFTIDSGVLI 1
54 EQSVCCFTID 5
55 ASLVKEQSVC 0
56 THGILASLVK 1
57 ILPCNTHGIL 14
58 EGDLHILPCN 10
59 KIAVNEGDLH 2
60 SINRIKIAVN 0
61 SSASVSINRI 0
62 VVNTGSSASV 0
63 DETTFVVNTG 5
64 TGFINDETTF 6
65 GAFIVTGFIN 2
66 TDPPYGAFIV 6
67 NLQQPTDPPY 6
68 DHTECNLQQP 4
69 IIEKLDHTEC 10
70 PNWSCIIEKL 20
71 ATVRGPNWSC 10
72 RPGVLATVRG 2
73 TYSTARPGVL 12
74 FSEVLTYSTA 1
75 VYKGSFSEVL 2
76 ARKLRVYKGS 1
77 NTPAEARKLR 1
78 LQYSENTPAE 1
79 LMQFLLQYSE 3
80 IEQNPLMQFL 4
81 LTFNYIEQNP 14
82 PNHANLTFNY 9
83 QSRGLPNHAN 7
84 VLITSQSRGL 1
85 KETINVLITS 0
86 THPYVKETIN 10
87 KFSTPTHPYV 10
88 NIDKVKFSTP 9
89 KVATSNIDKV 1
90 LHWSLKVATS 1
91 AFNGPLHWSL 16
92 LFNIKAFNGP 5
93 IEIECLFNIK 3
94 SNSKKIEIEC 0
95 RQEQVSNSKK 0
96 KITVNRQEQV 1
97 SNEVGKITVN 3
98 AVLYSSNEVG 0
99 NLKDLAVLYS 13
100 YLTYPNLKDL 8
101 RIRFTYLTYP 3
102 TETSCRIRFT 4
103 SWKWFTETSC 15
104 KNSWKSWKWF 32
105 TLHQKKNSWK 12
106 PSAETTLHQK 0
107 DPGKSPSAET 0
108 WERWTDPGKS 18
109 KGDSSWERWT 17
110 YIILNKGDSS 3
111 PLPKWYIILN 5
112 NAENIPLPKW 8
113 SLIKGNAENI 1
114 CSVNYSLIKG 16
115 EEDSSCSVNY 2
116 SLSQTEEDSS 0
117 PDPIESLSQT 1
118 EAKHQPDPIE 2
119 KDLRIEAKHQ 1
120 IIYDNKDLRI 2
121 KAVVSIIYDN 1
122 SGVSNKAVVS 0
123 KSPPSSGVSN 1
124 EMSAIKSPPS 0
125 DDNPIEMSAI 0
126 QEIKLDDNPI 2
127 GMGVVQEIKL 0
128 LLIGKGMGVV 7
129 DYHWTLLIGK 13
130 CTMNPDYHWT 25
131 KIVYDCTMNP 9
132 SSNCWKIVYD 13
133 CPESRSSNCW 3
134 RWDMLCPESR 20
135 NSPVKRWDML 52
136 VTETSNSPVK 0
137 EDSEIVTETS 0
138 IGPRFEDSEI 14
139 FFNYRIGPRF 8
140 RCGYLFFNYR 8
141 QYGQNRCGYL 6
142 MSRLLQYGQN 1
143 EIYGIMSRLL 4
144 IPALEEIYGI 5
145 FNPAVIPALE 3
146 TDEVTFNPAV 2
147 ISDASTDEVT 0
148 EWKVLISDAS 0
149 EVPIDEWKVL 82
150 FGRLEEVPID 4
151 LYGRLFGRLE 1
152 KGFYFLYGRL 9
153 TDREGKGFYF 16
154 VRMKSTDREG 1
155 RGSELVRMKS 0
156 VKIDSRGSEL 0
157 DTINKVKIDS 1
158 TKQSIDTINK 0
159 DAIRLTKQSI 0
160 TKGQLDAIRL 2
161 VLHYSTKGQL 9
162 TYARLVLHYS 1
163 GVGGDTYARL 2
164 MSKEPGVGGD 5
165 KTVVYMSKEP 10
166 GVSNEKTVVY 4
167 IAIILGVSNE 0
168 AVPILIAIIL 0
169 VIVAVAVPIL 1
170 STVVGVIVAV 1
171 RYCLISTVVG 1
172 IWERKRYCLI 5
173 YFTEKIWERK 6
174 NPIDPYFTEK 10
175 KCNEPNPIDP 16
176 QFQLAKCNEP 2
177 ECVSKQFQLA 0
178 LASSGECVSK 2
179 MELTKLASSG 0
180 PTCPNMELTK 2
181 VEVNNPTCPN 8
182 SRTELVEVNN 1
183 IKPFASRTEL 4
184 IETDEIKPFA 4
185 AVPSIIETDE 3
186 DEPREAVPSI 2
187 EADSRDEPRE 1
188 VHNEPEADSR 1
189 CYSVVVHNEP 10
190 EIIPPCYSVV 11
191 NPIEEEIIPP 5
192 EDAAPNPIEE 5
193 ATGGAEDAAP 3
194 IYIVQATGGA 1
195 MSQVDIYIVQ 0
196 AQPQYMSQVD 1
197 EEEPKAQPQY 3
198 PDNEQEEEPK 3
199 GAGGVPDNEQ 4
200 MQPKYGAGGV 2
201 NIPLHMQPKY 10
202 DEVTSNIPLH 1
203 EEAAIDEVTS 0
204 TKDLDEEAAI 2
205 PRYGATKDLD 3
206 NVNAQPRYGA 3
207 VLNWTNVNAQ 6
208 PSDPSVLNWT 17
209 SDISRPSDPS 2
210 VIESNSDISR 0
211 PSGFSVIESN 5
212 SNISCPSGFS 2
213 ILFQRSNISC 1
214 EDKPPILFQR 0
215 SKPSDEDKPP 3
216 WGGGNSKPSD 4
217 FNTFSWGGGN 17
218 DNPKNQFFNTFS 12