ID   CT203_HUMAN             Reviewed;         194 AA.
AC   Q8NBC4; B8JHY2;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   12-SEP-2018, entry version 68.
DE   RecName: Full=Uncharacterized protein C20orf203;
GN   Name=C20orf203;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=20376170; DOI=10.1371/journal.pcbi.1000734;
RA   Li C.Y., Zhang Y., Wang Z., Zhang Y., Cao C., Zhang P.W., Lu S.J.,
RA   Li X.M., Yu Q., Zheng X., Du Q., Uhl G.R., Liu Q.R., Wei L.;
RT   "A human-specific de novo protein-coding gene associated with human
RT   brain functions.";
RL   PLoS Comput. Biol. 6:E1000734-E1000734(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20376170}.
CC   -!- TISSUE SPECIFICITY: Expressed most abundantly in the brain at
CC       protein level. Present in cortex, cerebellum and midbrain. Found
CC       in neurons. Elevated expressions detected in Alzheimer brain
CC       samples. Also expressed in testis. {ECO:0000269|PubMed:20376170}.
CC   -!- MISCELLANEOUS: Originated from non-coding DNA sequences (insertion
CC       of repeat elements especially Alu). Seems to exist only in human.
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DR   EMBL; GU931819; ADF32072.1; -; mRNA.
DR   EMBL; GU931820; ADF32073.1; -; mRNA.
DR   EMBL; AK091025; BAC03569.1; -; mRNA.
DR   EMBL; FO393400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC105014; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS13203.1; -.
DR   RefSeq; NP_872390.2; NM_182584.2.
DR   UniGene; Hs.353262; -.
DR   SMR; Q8NBC4; -.
DR   BioGrid; 129958; 2.
DR   BioMuta; C20orf203; -.
DR   PRIDE; Q8NBC4; -.
DR   ProteomicsDB; 72757; -.
DR   Ensembl; ENST00000360785; ENSP00000495162; ENSG00000198547.
DR   Ensembl; ENST00000608990; ENSP00000495424; ENSG00000198547.
DR   GeneID; 284805; -.
DR   KEGG; hsa:284805; -.
DR   CTD; 284805; -.
DR   DisGeNET; 284805; -.
DR   GeneCards; C20orf203; -.
DR   HGNC; HGNC:26592; C20orf203.
DR   neXtProt; NX_Q8NBC4; -.
DR   OpenTargets; ENSG00000198547; -.
DR   PharmGKB; PA165392347; -.
DR   GeneTree; ENSGT00920000150801; -.
DR   InParanoid; Q8NBC4; -.
DR   GenomeRNAi; 284805; -.
DR   PRO; PR:Q8NBC4; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Reference proteome.
FT   CHAIN         1    194       Uncharacterized protein C20orf203.
FT                                /FTId=PRO_0000394501.
FT   COMPBIAS     84     87       Poly-Pro.
FT   CONFLICT    123    123       G -> R (in Ref. 1; ADF32072/ADF32073 and
FT                                2; BAC03569). {ECO:0000305}.
SQ   SEQUENCE   194 AA;  21159 MW;  4C0D18500B820F22 CRC64;
     MFPRPVLNSR AQAILLPQPP NMLDHRQWPP RLASFPFTKT GMLSRATSVL AGLTAHLWDL
     GGGAGRRTSK AQRVHPQPSH QRQPPPPQHP GPYQERIWVG GEGWGEVGGL RLSKVGRRDR
     EVGRGLRAPA GRGRAMGGMP RMGTVGDFGQ ALSSLAWTST CFQDFCLPSL PGKLPAPLIS
     KQQFLSNSSR SLFN
//