ID CT203_HUMAN Reviewed; 194 AA. AC Q8NBC4; B8JHY2; DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot. DT 15-JUN-2010, sequence version 2. DT 12-SEP-2018, entry version 68. DE RecName: Full=Uncharacterized protein C20orf203; GN Name=C20orf203; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=20376170; DOI=10.1371/journal.pcbi.1000734; RA Li C.Y., Zhang Y., Wang Z., Zhang Y., Cao C., Zhang P.W., Lu S.J., RA Li X.M., Yu Q., Zheng X., Du Q., Uhl G.R., Liu Q.R., Wei L.; RT "A human-specific de novo protein-coding gene associated with human RT brain functions."; RL PLoS Comput. Biol. 6:E1000734-E1000734(2010). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20376170}. CC -!- TISSUE SPECIFICITY: Expressed most abundantly in the brain at CC protein level. Present in cortex, cerebellum and midbrain. Found CC in neurons. Elevated expressions detected in Alzheimer brain CC samples. Also expressed in testis. {ECO:0000269|PubMed:20376170}. CC -!- MISCELLANEOUS: Originated from non-coding DNA sequences (insertion CC of repeat elements especially Alu). Seems to exist only in human. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; GU931819; ADF32072.1; -; mRNA. DR EMBL; GU931820; ADF32073.1; -; mRNA. DR EMBL; AK091025; BAC03569.1; -; mRNA. DR EMBL; FO393400; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC105014; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS13203.1; -. DR RefSeq; NP_872390.2; NM_182584.2. DR UniGene; Hs.353262; -. DR SMR; Q8NBC4; -. DR BioGrid; 129958; 2. DR BioMuta; C20orf203; -. DR PRIDE; Q8NBC4; -. DR ProteomicsDB; 72757; -. DR Ensembl; ENST00000360785; ENSP00000495162; ENSG00000198547. DR Ensembl; ENST00000608990; ENSP00000495424; ENSG00000198547. DR GeneID; 284805; -. DR KEGG; hsa:284805; -. DR CTD; 284805; -. DR DisGeNET; 284805; -. DR GeneCards; C20orf203; -. DR HGNC; HGNC:26592; C20orf203. DR neXtProt; NX_Q8NBC4; -. DR OpenTargets; ENSG00000198547; -. DR PharmGKB; PA165392347; -. DR GeneTree; ENSGT00920000150801; -. DR InParanoid; Q8NBC4; -. DR GenomeRNAi; 284805; -. DR PRO; PR:Q8NBC4; -. DR Proteomes; UP000005640; Chromosome 20. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. PE 2: Evidence at transcript level; KW Complete proteome; Cytoplasm; Reference proteome. FT CHAIN 1 194 Uncharacterized protein C20orf203. FT /FTId=PRO_0000394501. FT COMPBIAS 84 87 Poly-Pro. FT CONFLICT 123 123 G -> R (in Ref. 1; ADF32072/ADF32073 and FT 2; BAC03569). {ECO:0000305}. SQ SEQUENCE 194 AA; 21159 MW; 4C0D18500B820F22 CRC64; MFPRPVLNSR AQAILLPQPP NMLDHRQWPP RLASFPFTKT GMLSRATSVL AGLTAHLWDL GGGAGRRTSK AQRVHPQPSH QRQPPPPQHP GPYQERIWVG GEGWGEVGGL RLSKVGRRDR EVGRGLRAPA GRGRAMGGMP RMGTVGDFGQ ALSSLAWTST CFQDFCLPSL PGKLPAPLIS KQQFLSNSSR SLFN //