Disease Motifs
A Wild Speculative Excursion into the Field of Bioinformatics
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Parkinson's Disease (PD)

There were 103 proteins identified with some association with Parkinson's disease, one of which (AAKG2_HUMAN) was discarded for being a false positive, leaving 102 proteins that will be looked at here. This work has been done with databases that were downloaded from the EBI around the end of 2018 and start of 2019.

Unlike the previous occasion, I decided to keep Beta-synuclein (SYUB_HUMAN) in the dataset because of its connection with Alzheimer's disease which I think might be of greater interest, even though strictly speaking this protein can be seen as a false positive.

The basic imagery will be displayed here but the more in-depth analysis will be written for the second instalment/chapter for the book that I am writing (see below) and this will hopefully be released some time in the latter parts of 2019....hopefully, all being well.

To see the protein sequence analysis on the proteins that are associated with Parkinson's disease click on the following links:
Parkinson's disease dataset 2019
Set theory with the Parkinson's disease dataset 2019


Alzheimer's disease

There are a total of 98 proteins that seem to have some mention of Alzheimer's disease within the comments section of the protein datasheet. None were excluded. This work was done using a database that was downloaded from the EBI at the end of 2018 and the start of 2019.

To see the protein sequence analysis on the proteins that are associated with Alzheimer's disease click on the links below Alzheimer's disease protein dataset 2019
Set Theory with the Alzheimer's disease protein dataset 2019

Prion Diseases (CJD FFI and GSS)

Three dimensional structure of HuPrP(90-231 M129 Q212P).  DOI:10.2210/pdb2kun/pdb  2KUN.  Image produced courtesy of RCSB PDB
Human Prion Protein showing amino acid residue 90 to 231 containing the Q212P mutation that is believed to increase the probablity of an individual developing Gerstmann-Sträussler-Scheinker Disease GSS.
Image courtesy of the RCSB PDB
DOI:10.2210/pdb2kun/pdb
Some basic research into Prion diseases such as CJD, GSS and FFI. Largely work done on the prion protein as well as Cystatin-C and Gamma-enolase. The latter two more in regarding CJD.


Creutzfeldt - Jakob Disease (CJD)

Gerstmann Sträussler Scheinker Disease (GSS)

Fatal Familial Insomnia (FFI)










Disease Motifs - A Wild Speculative Excursion into the Field of Bioinformatics

I am in the process of writing a book about this work in general with all the explanations necessary and with some of the results of this research. Hopefully this might help and inspire other individuals to become involved.

You will find some of the Perl scripts code, which might be needed to get you started making your own disease protein datasets, on the additional resources page and these are also included in the book's appendices.

Please be aware that this instalment has a lot of colour images, so you might well think to download it on to your computer, if your Kindle or other device does not show coloured images properly.

If you are interested in buying this work please click on the link below.
Disease Motifs - A Wild Speculative Excursion into the Field of Bioinformatics

I have just completed the first version of the third chapter on Parkinson's disease but will probably have to re-do this at some stage.
Parkinson's Disease Protein Dataset 2019
This is actually included in the main book.

There is also a small work "A Collection of Bioinformatics Papers".
A Collection of Bioinformatics Papers
This is also included in the main book.

Additional Resources for the Book

There are some additional resources that will be available located on the Additional Resources page.

If you notice any sort of error on this website I would appreciate it if you would let me know - Thank You

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