Disease Motifs
Investigating the Biomechanics of Disease
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Phenotypic GSS Models



Typical GSS

CJD-like

Spastic Paraparesis P105L

In some families spastic paraparesis seemed to be the main symptom of the disease and the cerebellar dysfunction was not as prominent.

Alzheimer-like GSS without Aβ plaques F198S

Neocortical Neurofibrillary Tangles

Alzheimer-like GSS with Aβ plaques P105L with Q217R together

Neocortical Neurofibrillary Tangles and Aβ plaques

Alzheimer/Parkinson-like Q217R

Neocortical Neurofibrillary Tangles and degeneration in the Substantia Nigra