Disease Motifs
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Set Theory

Set Theory as applied to the proteins associated with Parkinson's disease

There are 69 subsets from the Parkinson's disease set so far but this may change as some sets maybe be merged together and other new sets may be created. If anyone would like to may any suggestions about, creating another set, deleting a set or merging two or more sets together, please feel free to do so in the COMMENTS section related to Set Theory. Some of these sets will be created in a very superficial way and have been grouped due to casual comments made by the person writing the details who just listed off symptoms on a particular protein's datasheet rather than listing specific, relevant and related details regarding a particular protein.



#1 ADENOCARCINOMA contains 4 proteins

PGFRB_HUMAN Platelet-derived growth factor receptor beta
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
TAF1_HUMAN Transcription initiation factor TFIID subunit
TRPM7_HUMAN Transient receptor potential cation channel

ADENOCARCINOMA Linkages


#2 ALZHEIMER contains 11 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
HRH2_HUMAN Histamine H2 receptor
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
PAWR_HUMAN PRKC apoptosis WT1 regulator protein
PCSK1_HUMAN Big LEN
PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
PSN1_HUMAN Presenilin-1 CTF12
SQSTM_HUMAN Sequestosome-1
SYUA_HUMAN Alpha-synuclein
TAU_HUMAN Microtubule-associated protein tau
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1

ALZHEIMER Linkages


#3 AMYOTROPHIC contains 10 proteins

ATX2_HUMAN Ataxin-2
CDK5_HUMAN Cyclin-dependent-like kinase 5
DCTN1_HUMAN Dynactin subunit 1
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PAWR_HUMAN PRKC apoptosis WT1 regulator protein
PCSK1_HUMAN Big LEN
RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
SQSTM_HUMAN Sequestosome-1
TERA_HUMAN Transitional endoplasmic reticulum ATPase
TRPM7_HUMAN Transient receptor potential cation channel

AMYOTROPHIC Linkages


#4 APOPTOSIS contains 12 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
CS012_HUMAN Protein C19orf12
DDIT4_HUMAN DNA damage-inducible transcript 4 protein
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PAWR_HUMAN PRKC apoptosis WT1 regulator protein
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
PRIO_HUMAN Major prion protein
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase
PSN1_HUMAN Presenilin-1 CTF12
SQSTM_HUMAN Sequestosome-1

APOPTOSIS Linkages


#5 ATAXIA contains 21 proteins

ADT1_HUMAN ADP/ATP translocase 1
AT132_HUMAN Probable cation-transporting ATPase 13A2
AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
ATX2_HUMAN Ataxin-2
COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
FRIL_HUMAN Ferritin light chain
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
PDGFB_HUMAN Platelet-derived growth factor subunit B
PEO1_HUMAN Twinkle protein, mitochondrial
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PRIO_HUMAN Major prion protein
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
S20A2_HUMAN Sodium-dependent phosphate transporter 2
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

ATAXIA Linkages


#6 BEHAV contains 8 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
CPLX1_HUMAN Complexin-1
PSN1_HUMAN Presenilin-1 CTF12
RB39B_HUMAN Ras-related protein Rab-39B
RENR_HUMAN Renin receptor
SQSTM_HUMAN Sequestosome-1
TAF1_HUMAN Transcription initiation factor TFIID subunit
TAU_HUMAN Microtubule-associated protein tau

BEHAV Linkages


#7 BREAST contains 6 proteins

KLK6_HUMAN Kallikrein-6
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
PGFRB_HUMAN Platelet-derived growth factor receptor beta
RNF11_HUMAN RING finger protein 11
SC6A3_HUMAN Sodium-dependent dopamine transporter
TRPM7_HUMAN Transient receptor potential cation channel

BREAST Linkages


#8 CALCIUM contains 13 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
CS012_HUMAN Protein C19orf12
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PDGFB_HUMAN Platelet-derived growth factor subunit B
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
PSN1_HUMAN Presenilin-1 CTF12
S20A2_HUMAN Sodium-dependent phosphate transporter 2
SYT11_HUMAN Synaptotagmin-11
TRPM7_HUMAN Transient receptor potential cation channel
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

CALCIUM Linkages


#9 CANCER contains 8 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
IF4G1_HUMAN Eukaryotic translation initiation factor 4
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
PAWR_HUMAN PRKC apoptosis WT1 regulator protein
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RNF11_HUMAN RING finger protein 11
SC6A3_HUMAN Sodium-dependent dopamine transporter

CANCER Linkages


#10 CARCINOMA contains 7 proteins

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PSN1_HUMAN Presenilin-1 CTF12
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
SQSTM_HUMAN Sequestosome-1
TAF1_HUMAN Transcription initiation factor TFIID subunit
TRPM7_HUMAN Transient receptor potential cation channel

CARCINOMA Linkages


#11 CARDIOMYOPATHY contains 21 proteins

ADT1_HUMAN ADP/ATP translocase 1
COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL
PSN1_HUMAN Presenilin-1 CTF12

CARDIOMYOPATHY Linkages


#12 CATARACT contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
FRIL_HUMAN Ferritin light chain
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

CATARACT Linkages


#13 CIRRHOSIS contains 2 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
ZNT10_HUMAN Zinc transporter 10

CIRRHOSIS Linkages


#14 COLORECTAL contains 4 proteins

IF4G1_HUMAN Eukaryotic translation initiation factor 4
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
TAF1_HUMAN Transcription initiation factor TFIID subunit

COLORECTAL Linkages


#15 COPPER contains 4 proteins

CERU_HUMAN Ceruloplasmin
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PRIO_HUMAN Major prion protein
SYUA_HUMAN Alpha-synuclein

COPPER Linkages


#16 DEMENTIA contains 25 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
ATX2_HUMAN Ataxin-2
DJC13_HUMAN DnaJ homolog subfamily C member
GLCM_HUMAN Glucosylceramidase
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PCSK1_HUMAN Big LEN
PDGFB_HUMAN Platelet-derived growth factor subunit B
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRIO_HUMAN Major prion protein
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
PSN1_HUMAN Presenilin-1 CTF12
S20A2_HUMAN Sodium-dependent phosphate transporter 2
SNCAP_HUMAN Synphilin-1
SQSTM_HUMAN Sequestosome-1
SYUA_HUMAN Alpha-synuclein
TAU_HUMAN Microtubule-associated protein tau
TERA_HUMAN Transitional endoplasmic reticulum ATPase
TM230_HUMAN Transmembrane protein 230
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
TRPM7_HUMAN Transient receptor potential cation channel
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

DEMENTIA Linkages


#17 DEPRESSION contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
DCTN1_HUMAN Dynactin subunit 1
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

DEPRESSION Linkages


#18 DIABETES contains 3 proteins

CERU_HUMAN Ceruloplasmin
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive

DIABETES Linkages


#19 DIURNAL contains 2 proteins

PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin

DIURNAL Linkages


#20 DYSTONIA contains 18 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
COASY_HUMAN Dephospho-CoA kinase
CS012_HUMAN Protein C19orf12
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
PDGFB_HUMAN Platelet-derived growth factor subunit B
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase
S20A2_HUMAN Sodium-dependent phosphate transporter 2
S39AE_HUMAN Zinc transporter ZIP14
SC6A3_HUMAN Sodium-dependent dopamine transporter
SYNJ1_HUMAN Synaptojanin-1
TAF1_HUMAN Transcription initiation factor TFIID subunit
TY3H_HUMAN Tyrosine 3-monooxygenase
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
ZNT10_HUMAN Zinc transporter 10

DYSTONIA Linkages


#21 EXTRAPYRAMIDAL contains 7 proteins

ATX2_HUMAN Ataxin-2
COASY_HUMAN Dephospho-CoA kinase
CS012_HUMAN Protein C19orf12
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
TAU_HUMAN Microtubule-associated protein tau
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
ZNT10_HUMAN Zinc transporter 10

EXTRAPYRAMIDAL Linkages


#22 FATIGABILITY contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

FATIGABILITY Linkages


#23 FINGER contains 7 proteins

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
RNF11_HUMAN RING finger protein 11
SQSTM_HUMAN Sequestosome-1
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
VPS41_HUMAN Vacuolar protein sorting-associated protein 41
ZN746_HUMAN Zinc finger protein 746

FINGER Linkages


#24 GASTR contains 5 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
HRH2_HUMAN Histamine H2 receptor
PGFRB_HUMAN Platelet-derived growth factor receptor beta
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
TRPM7_HUMAN Transient receptor potential cation channel

GASTR Linkages


#25 GLUCOSE contains 4 proteins

CPLX1_HUMAN Complexin-1
GLCM_HUMAN Glucosylceramidase
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2

GLUCOSE Linkages


#26 HEPARAN contains 4 proteins

CERU_HUMAN Ceruloplasmin
FGF20_HUMAN Fibroblast growth factor 20
KLK6_HUMAN Kallikrein-6
PRIO_HUMAN Major prion protein

HEPARAN Linkages


#27 HYPERREFLEXIA contains 3 proteins

CS012_HUMAN Protein C19orf12
FBX7_HUMAN F-box only protein 7
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial

HYPERREFLEXIA Linkages


#28 HYPOGONADISM contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

HYPOGONADISM Linkages


#29 HYPOREFLEXIA contains 1 protein

ATX2_HUMAN Ataxin-2

HYPOREFLEXIA Linkages


#30 HYPOVENTILATION contains 1 protein

TAU_HUMAN Microtubule-associated protein tau

HYPOVENTILATION Linkages


#31 INSOMNIA contains 1 protein

PRIO_HUMAN Major prion protein

INSOMNIA Linkages


#32 IRON contains 20 proteins

CERU_HUMAN Ceruloplasmin
COASY_HUMAN Dephospho-CoA kinase
CS012_HUMAN Protein C19orf12
DJC13_HUMAN DnaJ homolog subfamily C member
FRIL_HUMAN Ferritin light chain
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NUBPL_HUMAN Iron-sulfur protein NUBPL
PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
PRIO_HUMAN Major prion protein
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
S39AE_HUMAN Zinc transporter ZIP14
SYUA_HUMAN Alpha-synuclein
TM230_HUMAN Transmembrane protein 230
TY3H_HUMAN Tyrosine 3-monooxygenase
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein

IRON Linkages


#33 LACTIC contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

LACTIC Linkages


#34 LEBER contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL

LEBER Linkages


#35 LEIGH contains 20 proteins

COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
DPOG1_HUMAN DNA polymerase subunit gamma-1
FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL

LEIGH Linkages


#36 LEUKEMIA contains 3 proteins

PGFRB_HUMAN Platelet-derived growth factor receptor beta
S20A2_HUMAN Sodium-dependent phosphate transporter 2
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

LEUKEMIA Linkages


#37 LEUKODYSTROPHY contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL

LEUKODYSTROPHY Linkages


#38 LEVODOPA contains 11 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin
CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
IF4G1_HUMAN Eukaryotic translation initiation factor 4
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PERQ2_HUMAN PERQ amino acid-rich with GYF
SYNJ1_HUMAN Synaptojanin-1
TY3H_HUMAN Tyrosine 3-monooxygenase
VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
VPS35_HUMAN Vacuolar protein sorting-associated protein 35

LEVODOPA Linkages


#39 LEWY contains 26 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
AT132_HUMAN Probable cation-transporting ATPase 13A2
AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin
CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
DJC13_HUMAN DnaJ homolog subfamily C member
GLCM_HUMAN Glucosylceramidase
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
IF4G1_HUMAN Eukaryotic translation initiation factor 4
KLK6_HUMAN Kallikrein-6
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PACRG_HUMAN Parkin coregulated gene protein
PERQ2_HUMAN PERQ amino acid-rich with GYF
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
RNF11_HUMAN RING finger protein 11
SNCAP_HUMAN Synphilin-1
SQSTM_HUMAN Sequestosome-1
SYNJ1_HUMAN Synaptojanin-1
SYT11_HUMAN Synaptotagmin-11
SYUA_HUMAN Alpha-synuclein
TERA_HUMAN Transitional endoplasmic reticulum ATPase
TM230_HUMAN Transmembrane protein 230
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
VPS35_HUMAN Vacuolar protein sorting-associated protein 35

LEWY Linkages


#40 LUNG contains 5 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
COASY_HUMAN Dephospho-CoA kinase
PDGFB_HUMAN Platelet-derived growth factor subunit B
RENR_HUMAN Renin receptor
TAF1_HUMAN Transcription initiation factor TFIID subunit

LUNG Linkages


#41 MAGNESIUM contains 4 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
TRPM7_HUMAN Transient receptor potential cation channel

MAGNESIUM Linkages


#42 MANGANESE contains 3 proteins

PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
S39AE_HUMAN Zinc transporter ZIP14
ZNT10_HUMAN Zinc transporter 10

MANGANESE Linkages


#43 MELANOMA contains 1 protein

TAF1_HUMAN Transcription initiation factor TFIID subunit

MELANOMA Linkages


#44 MEMORY contains 3 proteins

PRIO_HUMAN Major prion protein
PSN1_HUMAN Presenilin-1 CTF12
TAU_HUMAN Microtubule-associated protein tau

MEMORY Linkages


#45 MITOCHOND contains 37 proteins

ADT1_HUMAN ADP/ATP translocase 1
CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
COASY_HUMAN Dephospho-CoA kinase
COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
CS012_HUMAN Protein C19orf12
DDIT4_HUMAN DNA damage-inducible transcript 4 protein
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
FBX7_HUMAN F-box only protein 7
FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
KLK6_HUMAN Kallikrein-6
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PEO1_HUMAN Twinkle protein, mitochondrial
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
TERA_HUMAN Transitional endoplasmic reticulum ATPase
VP13C_HUMAN Vacuolar protein sorting-associated protein 13C

MITOCHOND Linkages


#46 MT-C1D contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL

MT-C1D Linkages


#47 MYOCLONUS contains 2 proteins

ATX2_HUMAN Ataxin-2
DPOG1_HUMAN DNA polymerase subunit gamma-1

MYOCLONUS Linkages


#48 NBIA contains 5 proteins

COASY_HUMAN Dephospho-CoA kinase
CS012_HUMAN Protein C19orf12
FRIL_HUMAN Ferritin light chain
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein

NBIA Linkages


#49 NYSTAGMUS contains 2 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1

NYSTAGMUS Linkages


#50 OPHTHALMOPLEGIA contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
ATX2_HUMAN Ataxin-2
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B

OPHTHALMOPLEGIA Linkages


#51 OPTIC contains 21 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
ATX2_HUMAN Ataxin-2
FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
MIMIT_HUMAN Mimitin, mitochondrial
NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
NUBPL_HUMAN Iron-sulfur protein NUBPL
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1

OPTIC Linkages


#52 OVARIAN contains 4 proteins

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PEO1_HUMAN Twinkle protein, mitochondrial
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
TRPM7_HUMAN Transient receptor potential cation channel

OVARIAN Linkages


#53 PALSY contains 2 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
TAU_HUMAN Microtubule-associated protein tau

PALSY Linkages


#54 PARK contains 25 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
CERU_HUMAN Ceruloplasmin
CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
DCTN1_HUMAN Dynactin subunit 1
DJC13_HUMAN DnaJ homolog subfamily C member
DPOG1_HUMAN DNA polymerase subunit gamma-1
FBX7_HUMAN F-box only protein 7
GLCM_HUMAN Glucosylceramidase
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
IF4G1_HUMAN Eukaryotic translation initiation factor 4
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PERQ2_HUMAN PERQ amino acid-rich with GYF
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
SNCAP_HUMAN Synphilin-1
SYNJ1_HUMAN Synaptojanin-1
SYUA_HUMAN Alpha-synuclein
TAU_HUMAN Microtubule-associated protein tau
TM230_HUMAN Transmembrane protein 230
TY3H_HUMAN Tyrosine 3-monooxygenase
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
VPS35_HUMAN Vacuolar protein sorting-associated protein 35

PARK Linkages


#55 PICK contains 4 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
PCSK1_HUMAN Big LEN
RB39B_HUMAN Ras-related protein Rab-39B
TAU_HUMAN Microtubule-associated protein tau

PICK Linkages


#56 POLYMERASE contains 4 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
TAF1_HUMAN Transcription initiation factor TFIID subunit
TERA_HUMAN Transitional endoplasmic reticulum ATPase

POLYMERASE Linkages


#57 PROSTATE contains 4 proteins

KLK6_HUMAN Kallikrein-6
PEO1_HUMAN Twinkle protein, mitochondrial
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
RNF11_HUMAN RING finger protein 11

PROSTATE Linkages


#58 PSYCHIATRIC contains 9 proteins

DCTN1_HUMAN Dynactin subunit 1
HRH2_HUMAN Histamine H2 receptor
PDGFB_HUMAN Platelet-derived growth factor subunit B
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRIO_HUMAN Major prion protein
RB39B_HUMAN Ras-related protein Rab-39B
S20A2_HUMAN Sodium-dependent phosphate transporter 2
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

PSYCHIATRIC Linkages


#59 PYRAMIDAL contains 13 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
ATX2_HUMAN Ataxin-2
COASY_HUMAN Dephospho-CoA kinase
COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
CS012_HUMAN Protein C19orf12
FBX7_HUMAN F-box only protein 7
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
SC6A3_HUMAN Sodium-dependent dopamine transporter
TAU_HUMAN Microtubule-associated protein tau
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
ZNT10_HUMAN Zinc transporter 10

PYRAMIDAL Linkages


#60 SARCOMA contains 2 proteins

PDGFB_HUMAN Platelet-derived growth factor subunit B
S20A2_HUMAN Sodium-dependent phosphate transporter 2

SARCOMA Linkages


#61 SENSORY contains 8 proteins

ADT1_HUMAN ADP/ATP translocase 1
ATX2_HUMAN Ataxin-2
DCTN1_HUMAN Dynactin subunit 1
DPOG1_HUMAN DNA polymerase subunit gamma-1
DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
PEO1_HUMAN Twinkle protein, mitochondrial
RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
TERA_HUMAN Transitional endoplasmic reticulum ATPase

SENSORY Linkages


#62 SLEEP contains 4 proteins

DCTN1_HUMAN Dynactin subunit 1
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRIO_HUMAN Major prion protein
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin

SLEEP Linkages


#63 SPONGIFORM contains 2 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
PRIO_HUMAN Major prion protein

SPONGIFORM Linkages


#64 SULFUR contains 6 proteins

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
NUBPL_HUMAN Iron-sulfur protein NUBPL

SULFUR Linkages


#65 THYROID contains 8 proteins

HTRA2_HUMAN Serine protease HTRA2, mitochondrial
KLK6_HUMAN Kallikrein-6
PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
PDGFB_HUMAN Platelet-derived growth factor subunit B
PGFRB_HUMAN Platelet-derived growth factor receptor beta
S20A2_HUMAN Sodium-dependent phosphate transporter 2
S39AE_HUMAN Zinc transporter ZIP14
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

THYROID Linkages


#66 TREMOR contains 28 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
ATX2_HUMAN Ataxin-2
AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin
CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
DJC13_HUMAN DnaJ homolog subfamily C member
FBX7_HUMAN F-box only protein 7
GLCM_HUMAN Glucosylceramidase
HTRA2_HUMAN Serine protease HTRA2, mitochondrial
IF4G1_HUMAN Eukaryotic translation initiation factor 4
LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
PDGFB_HUMAN Platelet-derived growth factor subunit B
PERQ2_HUMAN PERQ amino acid-rich with GYF
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RENR_HUMAN Renin receptor
S20A2_HUMAN Sodium-dependent phosphate transporter 2
SNCAP_HUMAN Synphilin-1
SYNJ1_HUMAN Synaptojanin-1
SYUA_HUMAN Alpha-synuclein
TAU_HUMAN Microtubule-associated protein tau
TM230_HUMAN Transmembrane protein 230
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
VPS35_HUMAN Vacuolar protein sorting-associated protein 35
XPR1_HUMAN Xenotropic and polytropic retrovirus receptor

TREMOR Linkages


#67 UBIQUITIN contains 24 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
ATX2_HUMAN Ataxin-2
CDK5_HUMAN Cyclin-dependent-like kinase 5
DCTN1_HUMAN Dynactin subunit 1
DDIT4_HUMAN DNA damage-inducible transcript 4 protein
FBX7_HUMAN F-box only protein 7
GPR37_HUMAN Prosaposin receptor GPR37
PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
PGFRB_HUMAN Platelet-derived growth factor receptor beta
PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
RNF11_HUMAN RING finger protein 11
SEPT5_HUMAN Septin-5
SNCAP_HUMAN Synphilin-1
SQSTM_HUMAN Sequestosome-1
SYT11_HUMAN Synaptotagmin-11
SYUA_HUMAN Alpha-synuclein
TAU_HUMAN Microtubule-associated protein tau
TERA_HUMAN Transitional endoplasmic reticulum ATPase
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
VPS35_HUMAN Vacuolar protein sorting-associated protein 35
ZN746_HUMAN Zinc finger protein 746

UBIQUITIN Linkages


#68 WEIGHT contains 2 proteins

DCTN1_HUMAN Dynactin subunit 1
PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive

WEIGHT Linkages


#69 ZINC contains 12 proteins

PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
PRIO_HUMAN Major prion protein
PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
RNF11_HUMAN RING finger protein 11
S39AE_HUMAN Zinc transporter ZIP14
SQSTM_HUMAN Sequestosome-1
TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
TRPM7_HUMAN Transient receptor potential cation channel
VPS41_HUMAN Vacuolar protein sorting-associated protein 41
ZN746_HUMAN Zinc finger protein 746
ZNT10_HUMAN Zinc transporter 10

ZINC Linkages