Disease Motifs
Investigating the Biomechanics of Disease
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Go Sets

Set Theory with GO annotation.

There are 69 subsets from the Parkinson's disease set so far but this may change as some sets maybe be merged together and other new sets may be created. If anyone would like to may any suggestions about, creating another set, deleting a set or merging two or more sets together, please feel free to do so in the COMMENTS section related to Set Theory. Some of these sets will be created in a very superficial way and have been grouped due to casual comments made by the person writing the details who just listed off symptoms on a particular protein's datasheet rather than listing specific, relevant and related details regarding a particular protein.



#1 ADENOCARCINOMA contains 4 proteins

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


ADENOCARCINOMA Linkages


#2 ALZHEIMER contains 11 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

HRH2_HUMAN Histamine H2 receptor
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004969; F:histamine receptor activity; TAS:ProtInc.
GO:0048565; P:digestive tract development; IEA:Ensembl.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl.
GO:0048732; P:gland development; IEA:Ensembl.
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0007613; P:memory; IEA:Ensembl.
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:1901998; P:toxin transport; IEA:Ensembl.
GO:0008542; P:visual learning; IEA:Ensembl.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005261; F:cation channel activity; ISS:UniProtKB.
GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro.
GO:0006812; P:cation transport; ISS:UniProtKB.
GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IMP:UniProtKB.
GO:0033625; P:positive regulation of integrin activation; IMP:UniProtKB.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


ALZHEIMER Linkages


#3 AMYOTROPHIC contains 10 proteins

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

DCTN1_HUMAN Dynactin subunit 1
GO:0031252; C:cell leading edge; IEA:Ensembl.
GO:0005814; C:centriole; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005869; C:dynactin complex; IEA:InterPro.
GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0035371; C:microtubule plus-end; IDA:UniProtKB.
GO:0005635; C:nuclear envelope; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0000922; C:spindle pole; IDA:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0003774; F:motor activity; IEA:UniProtKB-KW.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0010457; P:centriole-centriole cohesion; IMP:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:Reactome.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0032402; P:melanosome transport; IEA:Ensembl.
GO:0034454; P:microtubule anchoring at centrosome; IMP:UniProtKB.
GO:0007067; P:mitotic nuclear division; NAS:ProtInc.
GO:0007399; P:nervous system development; NAS:UniProtKB.
GO:1905515; P:non-motile cilium assembly; IMP:UniProtKB.
GO:0051081; P:nuclear envelope disassembly; IMP:UniProtKB.
GO:0090063; P:positive regulation of microtubule nucleation; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
GO:0010970; P:transport along microtubule; IEA:InterPro.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
GO:0005813; C:centrosome; TAS:UniProtKB.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000226; P:microtubule cytoskeleton organization; TAS:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TERA_HUMAN Transitional endoplasmic reticulum ATPase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0036513; C:Derlin-1 retrotranslocation complex; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005811; C:lipid particle; IDA:MGI.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0000502; C:proteasome complex; IDA:BHF-UCL.
GO:0035861; C:site of double-strand break; IDA:UniProtKB.
GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; ISS:ParkinsonsUK-UCL.
GO:1990730; C:VCP-NSFL1C complex; ISS:ParkinsonsUK-UCL.
GO:0043531; F:ADP binding; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; IMP:UniProtKB.
GO:1904288; F:BAT3 complex binding; IPI:ParkinsonsUK-UCL.
GO:0035800; F:deubiquitinase activator activity; IDA:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.
GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0044389; F:ubiquitin-like protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO:0070842; P:aggresome assembly; IEA:Ensembl.
GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO:0097352; P:autophagosome maturation; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006302; P:double-strand break repair; IDA:UniProtKB.
GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0036503; P:ERAD pathway; IMP:UniProtKB.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0045184; P:establishment of protein localization; TAS:UniProtKB.
GO:0072389; P:flavin adenine dinucleotide catabolic process; IMP:ParkinsonsUK-UCL.
GO:0006734; P:NADH metabolic process; IMP:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903007; P:positive regulation of Lys63-specific deubiquitinase activity; IDA:ParkinsonsUK-UCL.
GO:0010918; P:positive regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:1903862; P:positive regulation of oxidative phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903006; P:positive regulation of protein K63-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0034214; P:protein hexamerization; IEA:Ensembl.
GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO:0018279; P:protein N-linked glycosylation via asparagine; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
GO:1903715; P:regulation of aerobic respiration; IMP:ParkinsonsUK-UCL.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IDA:UniProtKB.
GO:0019985; P:translesion synthesis; IMP:UniProtKB.
GO:0019079; P:viral genome replication; IMP:CACAO.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


AMYOTROPHIC Linkages


#4 APOPTOSIS contains 12 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

DDIT4_HUMAN DNA damage-inducible transcript 4 protein
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005622; C:intracellular; IDA:LIFEdb.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0008283; P:cell proliferation; ISS:UniProtKB.
GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISS:UniProtKB.
GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl.
GO:1902532; P:negative regulation of intracellular signal transduction; ISS:UniProtKB.
GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISS:UniProtKB.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.
GO:0032007; P:negative regulation of TOR signaling; IMP:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
GO:1901216; P:positive regulation of neuron death; ISS:UniProtKB.
GO:0043241; P:protein complex disassembly; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IDA:UniProtKB.

HTRA2_HUMAN Serine protease HTRA2, mitochondrial
GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB.
GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB.
GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0044257; P:cellular protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB.
GO:0034605; P:cellular response to heat; IDA:UniProtKB.
GO:0035458; P:cellular response to interferon-beta; IDA:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071300; P:cellular response to retinoic acid; IDA:ParkinsonsUK-UCL.
GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0016540; P:protein autoprocessing; TAS:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030159; F:receptor signaling complex scaffold activity; IC:ParkinsonsUK-UCL.
GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.
GO:0000149; F:SNARE binding; IPI:ParkinsonsUK-UCL.
GO:0017075; F:syntaxin-1 binding; IPI:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IDA:BHF-UCL.
GO:0000187; P:activation of MAPK activity; IMP:ParkinsonsUK-UCL.
GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0019722; P:calcium-mediated signaling; IMP:ParkinsonsUK-UCL.
GO:0060070; P:canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0034613; P:cellular protein localization; ISS:ParkinsonsUK-UCL.
GO:1903351; P:cellular response to dopamine; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0009267; P:cellular response to starvation; IMP:ParkinsonsUK-UCL.
GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
GO:0006897; P:endocytosis; IMP:ParkinsonsUK-UCL.
GO:0060079; P:excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0035640; P:exploration behavior; IMP:BHF-UCL.
GO:0007030; P:Golgi organization; IMP:ParkinsonsUK-UCL.
GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.
GO:0035556; P:intracellular signal transduction; ISS:ParkinsonsUK-UCL.
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO:0007040; P:lysosome organization; IMP:ParkinsonsUK-UCL.
GO:0000165; P:MAPK cascade; IDA:UniProtKB.
GO:0051646; P:mitochondrion localization; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0034260; P:negative regulation of GTPase activity; IDA:MGI.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:ParkinsonsUK-UCL.
GO:0010955; P:negative regulation of protein processing; IDA:ParkinsonsUK-UCL.
GO:1903217; P:negative regulation of protein processing involved in protein targeting to mitochondrion; IC:ParkinsonsUK-UCL.
GO:1903215; P:negative regulation of protein targeting to mitochondrion; IDA:ParkinsonsUK-UCL.
GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.
GO:0070997; P:neuron death; IMP:BHF-UCL.
GO:0048812; P:neuron projection morphogenesis; IMP:UniProtKB.
GO:0021772; P:olfactory bulb development; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:0016310; P:phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IC:ParkinsonsUK-UCL.
GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:1902499; P:positive regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0072593; P:reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:ParkinsonsUK-UCL.
GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IMP:ParkinsonsUK-UCL.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL.
GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.
GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.
GO:0035751; P:regulation of lysosomal lumen pH; IMP:ParkinsonsUK-UCL.
GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.
GO:0051900; P:regulation of mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0090140; P:regulation of mitochondrial fission; TAS:ParkinsonsUK-UCL.
GO:1902692; P:regulation of neuroblast proliferation; IMP:ParkinsonsUK-UCL.
GO:1901214; P:regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO:0014041; P:regulation of neuron maturation; IMP:ParkinsonsUK-UCL.
GO:0010738; P:regulation of protein kinase A signaling; ISS:ParkinsonsUK-UCL.
GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IGI:ParkinsonsUK-UCL.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:ParkinsonsUK-UCL.
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:ParkinsonsUK-UCL.
GO:1904887; P:Wnt signalosome assembly; IPI:ParkinsonsUK-UCL.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003725; F:double-stranded RNA binding; IDA:BHF-UCL.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO:0031047; P:gene silencing by RNA; TAS:Reactome.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0042473; P:outer ear morphogenesis; IEA:Ensembl.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0031054; P:pre-miRNA processing; IDA:BHF-UCL.
GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IDA:BHF-UCL.
GO:0030422; P:production of siRNA involved in RNA interference; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IEA:Ensembl.
GO:0009615; P:response to virus; TAS:ProtInc.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.


APOPTOSIS Linkages


#5 ATAXIA contains 21 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0044326; C:dendritic spine neck; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0042383; C:sarcolemma; IEA:Ensembl.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IC:UniProtKB.
GO:0045202; C:synapse; ISS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:UniProtKB.
GO:0086037; F:sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA:Ensembl.
GO:1990239; F:steroid hormone binding; NAS:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0015991; P:ATP hydrolysis coupled proton transport; IBA:GO_Central.
GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL.
GO:0071383; P:cellular response to steroid hormone stimulus; NAS:BHF-UCL.
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0010107; P:potassium ion import; IDA:BHF-UCL.
GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:1903416; P:response to glycoside; NAS:BHF-UCL.
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL.
GO:0008542; P:visual learning; IEA:Ensembl.

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
GO:0031305; C:integral component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IMP:UniProtKB.
GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-HAMAP.
GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

FRIL_HUMAN Ferritin light chain
GO:0044754; C:autolysosome; IDA:MGI.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0008043; C:intracellular ferritin complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0008199; F:ferric iron binding; IEA:InterPro.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005506; F:iron ion binding; IDA:UniProtKB.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
GO:0055072; P:iron ion homeostasis; TAS:UniProtKB.
GO:0006826; P:iron ion transport; IEA:InterPro.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

PDGFB_HUMAN Platelet-derived growth factor subunit B
GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IBA:GO_Central.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
GO:0005518; F:collagen binding; IDA:MGI.
GO:0008083; F:growth factor activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0048407; F:platelet-derived growth factor binding; IPI:BHF-UCL.
GO:0005161; F:platelet-derived growth factor receptor binding; NAS:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; TAS:Reactome.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; IDA:BHF-UCL.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1905064; P:negative regulation of vascular smooth muscle cell differentiation; IDA:BHF-UCL.
GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090280; P:positive regulation of calcium ion import; IDA:UniProtKB.
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
GO:2000573; P:positive regulation of DNA biosynthetic process; IDA:UniProtKB.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO:1900127; P:positive regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; IDA:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IDA:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IDA:BHF-UCL.
GO:1905176; P:positive regulation of vascular smooth muscle cell dedifferentiation; IDA:BHF-UCL.
GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IDA:BHF-UCL.
GO:0070528; P:protein kinase C signaling; IMP:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

S20A2_HUMAN Sodium-dependent phosphate transporter 2
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
GO:0006811; P:ion transport; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
GO:0005794; C:Golgi apparatus; IBA:GO_Central.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0015562; F:efflux transmembrane transporter activity; IMP:UniProtKB.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0000822; F:inositol hexakisphosphate binding; IDA:UniProtKB.
GO:0015114; F:phosphate ion transmembrane transporter activity; IMP:UniProtKB.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IMP:UniProtKB.
GO:0030643; P:cellular phosphate ion homeostasis; IMP:UniProtKB.
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0035435; P:phosphate ion transmembrane transport; IMP:UniProtKB.
GO:0009615; P:response to virus; IEA:Ensembl.


ATAXIA Linkages


#6 BEHAV contains 8 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

CPLX1_HUMAN Complexin-1
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Ensembl.
GO:0070554; C:synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; TAS:ParkinsonsUK-UCL.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0005326; F:neurotransmitter transporter activity; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
GO:0006887; P:exocytosis; TAS:ProtInc.
GO:0014047; P:glutamate secretion; TAS:Reactome.
GO:0030073; P:insulin secretion; IEA:Ensembl.
GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
GO:0017157; P:regulation of exocytosis; TAS:ParkinsonsUK-UCL.
GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

RB39B_HUMAN Ras-related protein Rab-39B
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0005622; C:intracellular; IDA:LIFEdb.
GO:0043005; C:neuron projection; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0031982; C:vesicle; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0031489; F:myosin V binding; IPI:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0050808; P:synapse organization; ISS:UniProtKB.
GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.

RENR_HUMAN Renin receptor
GO:0009897; C:external side of plasma membrane; IDA:HGNC.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004872; F:receptor activity; IEA:InterPro.
GO:0002003; P:angiotensin maturation; IDA:HGNC.
GO:0048069; P:eye pigmentation; IMP:UniProtKB.
GO:0060323; P:head morphogenesis; IMP:UniProtKB.
GO:0032914; P:positive regulation of transforming growth factor beta1 production; IDA:HGNC.
GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:UniProtKB.
GO:0043408; P:regulation of MAPK cascade; IDA:HGNC.
GO:0021903; P:rostrocaudal neural tube patterning; IMP:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


BEHAV Linkages


#7 BREAST contains 6 proteins

KLK6_HUMAN Kallikrein-6
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0045171; C:intercellular bridge; IDA:HPA.
GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0042982; P:amyloid precursor protein metabolic process; NAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.
GO:0030574; P:collagen catabolic process; NAS:UniProtKB.
GO:0042445; P:hormone metabolic process; NAS:UniProtKB.
GO:0042552; P:myelination; NAS:UniProtKB.
GO:0070997; P:neuron death; IMP:UniProtKB.
GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
GO:0016540; P:protein autoprocessing; NAS:UniProtKB.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0045595; P:regulation of cell differentiation; NAS:UniProtKB.
GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0042246; P:tissue regeneration; NAS:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

RNF11_HUMAN RING finger protein 11
GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase.
GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.

SC6A3_HUMAN Sodium-dependent dopamine transporter
GO:0030424; C:axon; IDA:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0016600; C:flotillin complex; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0005329; F:dopamine transmembrane transporter activity; IDA:UniProtKB.
GO:0005330; F:dopamine:sodium symporter activity; IBA:GO_Central.
GO:0008144; F:drug binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008504; F:monoamine transmembrane transporter activity; IDA:MGI.
GO:0021984; P:adenohypophysis development; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO:0042420; P:dopamine catabolic process; IEA:Ensembl.
GO:0015872; P:dopamine transport; IDA:UniProtKB.
GO:0090494; P:dopamine uptake; IDA:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IBA:GO_Central.
GO:0007595; P:lactation; IEA:Ensembl.
GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO:0015844; P:monoamine transport; IDA:MGI.
GO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome.
GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO:0060134; P:prepulse inhibition; IEA:Ensembl.
GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051591; P:response to cAMP; IEA:Ensembl.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0045471; P:response to ethanol; IEA:Ensembl.
GO:0010039; P:response to iron ion; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.
GO:0007608; P:sensory perception of smell; IEA:Ensembl.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


BREAST Linkages


#8 CALCIUM contains 13 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030159; F:receptor signaling complex scaffold activity; IC:ParkinsonsUK-UCL.
GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.
GO:0000149; F:SNARE binding; IPI:ParkinsonsUK-UCL.
GO:0017075; F:syntaxin-1 binding; IPI:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IDA:BHF-UCL.
GO:0000187; P:activation of MAPK activity; IMP:ParkinsonsUK-UCL.
GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0019722; P:calcium-mediated signaling; IMP:ParkinsonsUK-UCL.
GO:0060070; P:canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0034613; P:cellular protein localization; ISS:ParkinsonsUK-UCL.
GO:1903351; P:cellular response to dopamine; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0009267; P:cellular response to starvation; IMP:ParkinsonsUK-UCL.
GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
GO:0006897; P:endocytosis; IMP:ParkinsonsUK-UCL.
GO:0060079; P:excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0035640; P:exploration behavior; IMP:BHF-UCL.
GO:0007030; P:Golgi organization; IMP:ParkinsonsUK-UCL.
GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.
GO:0035556; P:intracellular signal transduction; ISS:ParkinsonsUK-UCL.
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO:0007040; P:lysosome organization; IMP:ParkinsonsUK-UCL.
GO:0000165; P:MAPK cascade; IDA:UniProtKB.
GO:0051646; P:mitochondrion localization; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0034260; P:negative regulation of GTPase activity; IDA:MGI.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:ParkinsonsUK-UCL.
GO:0010955; P:negative regulation of protein processing; IDA:ParkinsonsUK-UCL.
GO:1903217; P:negative regulation of protein processing involved in protein targeting to mitochondrion; IC:ParkinsonsUK-UCL.
GO:1903215; P:negative regulation of protein targeting to mitochondrion; IDA:ParkinsonsUK-UCL.
GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.
GO:0070997; P:neuron death; IMP:BHF-UCL.
GO:0048812; P:neuron projection morphogenesis; IMP:UniProtKB.
GO:0021772; P:olfactory bulb development; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:0016310; P:phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IC:ParkinsonsUK-UCL.
GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:1902499; P:positive regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0072593; P:reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:ParkinsonsUK-UCL.
GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IMP:ParkinsonsUK-UCL.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL.
GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.
GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.
GO:0035751; P:regulation of lysosomal lumen pH; IMP:ParkinsonsUK-UCL.
GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.
GO:0051900; P:regulation of mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0090140; P:regulation of mitochondrial fission; TAS:ParkinsonsUK-UCL.
GO:1902692; P:regulation of neuroblast proliferation; IMP:ParkinsonsUK-UCL.
GO:1901214; P:regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO:0014041; P:regulation of neuron maturation; IMP:ParkinsonsUK-UCL.
GO:0010738; P:regulation of protein kinase A signaling; ISS:ParkinsonsUK-UCL.
GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IGI:ParkinsonsUK-UCL.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:ParkinsonsUK-UCL.
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:ParkinsonsUK-UCL.
GO:1904887; P:Wnt signalosome assembly; IPI:ParkinsonsUK-UCL.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PDGFB_HUMAN Platelet-derived growth factor subunit B
GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IBA:GO_Central.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
GO:0005518; F:collagen binding; IDA:MGI.
GO:0008083; F:growth factor activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0048407; F:platelet-derived growth factor binding; IPI:BHF-UCL.
GO:0005161; F:platelet-derived growth factor receptor binding; NAS:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; TAS:Reactome.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; IDA:BHF-UCL.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1905064; P:negative regulation of vascular smooth muscle cell differentiation; IDA:BHF-UCL.
GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090280; P:positive regulation of calcium ion import; IDA:UniProtKB.
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
GO:2000573; P:positive regulation of DNA biosynthetic process; IDA:UniProtKB.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO:1900127; P:positive regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; IDA:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IDA:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IDA:BHF-UCL.
GO:1905176; P:positive regulation of vascular smooth muscle cell dedifferentiation; IDA:BHF-UCL.
GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IDA:BHF-UCL.
GO:0070528; P:protein kinase C signaling; IMP:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

S20A2_HUMAN Sodium-dependent phosphate transporter 2
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
GO:0006811; P:ion transport; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.

SYT11_HUMAN Synaptotagmin-11
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0043197; C:dendritic spine; ISS:ParkinsonsUK-UCL.
GO:0032009; C:early phagosome; ISS:ParkinsonsUK-UCL.
GO:0060076; C:excitatory synapse; ISS:ParkinsonsUK-UCL.
GO:0060077; C:inhibitory synapse; ISS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO:0005764; C:lysosome; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0001891; C:phagocytic cup; IEA:Ensembl.
GO:0045335; C:phagocytic vesicle; ISS:ParkinsonsUK-UCL.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0014069; C:postsynaptic density; ISS:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; ISS:ParkinsonsUK-UCL.
GO:0048787; C:presynaptic active zone membrane; ISS:ParkinsonsUK-UCL.
GO:0055037; C:recycling endosome; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; ISS:ParkinsonsUK-UCL.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0030276; F:clathrin binding; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; ISS:ParkinsonsUK-UCL.
GO:0019905; F:syntaxin binding; IBA:GO_Central.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990927; P:calcium ion regulated lysosome exocytosis; ISS:ParkinsonsUK-UCL.
GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
GO:1900165; P:negative regulation of interleukin-6 secretion; ISS:ParkinsonsUK-UCL.
GO:1905154; P:negative regulation of membrane invagination; IEA:Ensembl.
GO:0046929; P:negative regulation of neurotransmitter secretion; TAS:ParkinsonsUK-UCL.
GO:0050765; P:negative regulation of phagocytosis; IEA:Ensembl.
GO:1900243; P:negative regulation of synaptic vesicle endocytosis; IEA:Ensembl.
GO:1904468; P:negative regulation of tumor necrosis factor secretion; ISS:ParkinsonsUK-UCL.
GO:0001778; P:plasma membrane repair; ISS:ParkinsonsUK-UCL.
GO:1905171; P:positive regulation of protein localization to phagocytic vesicle; ISS:ParkinsonsUK-UCL.
GO:0051289; P:protein homotetramerization; ISS:ParkinsonsUK-UCL.
GO:1900424; P:regulation of defense response to bacterium; IEA:Ensembl.
GO:1905162; P:regulation of phagosome maturation; IC:ParkinsonsUK-UCL.
GO:0006906; P:vesicle fusion; IBA:GO_Central.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.

XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
GO:0005794; C:Golgi apparatus; IBA:GO_Central.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0015562; F:efflux transmembrane transporter activity; IMP:UniProtKB.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0000822; F:inositol hexakisphosphate binding; IDA:UniProtKB.
GO:0015114; F:phosphate ion transmembrane transporter activity; IMP:UniProtKB.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IMP:UniProtKB.
GO:0030643; P:cellular phosphate ion homeostasis; IMP:UniProtKB.
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0035435; P:phosphate ion transmembrane transport; IMP:UniProtKB.
GO:0009615; P:response to virus; IEA:Ensembl.


CALCIUM Linkages


#9 CANCER contains 8 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome.
GO:0060510; P:Type II pneumocyte differentiation; IEA:Ensembl.

IF4G1_HUMAN Eukaryotic translation initiation factor 4
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:AgBase.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IMP:ParkinsonsUK-UCL.
GO:0005844; C:polysome; IMP:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:AgBase.
GO:0003729; F:mRNA binding; IDA:ParkinsonsUK-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0032947; F:protein complex scaffold; TAS:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; TAS:ParkinsonsUK-UCL.
GO:0008135; F:translation factor activity, RNA binding; IMP:ParkinsonsUK-UCL.
GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
GO:0031369; F:translation initiation factor binding; TAS:ParkinsonsUK-UCL.
GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO:0002191; P:cap-dependent translational initiation; TAS:ParkinsonsUK-UCL.
GO:0034645; P:cellular macromolecule biosynthetic process; IGI:ParkinsonsUK-UCL.
GO:0032502; P:developmental process; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
GO:0030307; P:positive regulation of cell growth; IMP:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:ParkinsonsUK-UCL.
GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:2000507; P:positive regulation of energy homeostasis; IMP:ParkinsonsUK-UCL.
GO:1905537; P:positive regulation of eukaryotic translation initiation factor 4F complex assembly; IMP:ParkinsonsUK-UCL.
GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:ParkinsonsUK-UCL.
GO:1905618; P:positive regulation of miRNA mediated inhibition of translation; IDA:ParkinsonsUK-UCL.
GO:1905612; P:positive regulation of mRNA cap binding; IDA:ParkinsonsUK-UCL.
GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0080135; P:regulation of cellular response to stress; TAS:ParkinsonsUK-UCL.
GO:0060964; P:regulation of gene silencing by miRNA; TAS:ParkinsonsUK-UCL.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
GO:0006412; P:translation; IMP:ParkinsonsUK-UCL.
GO:0006413; P:translational initiation; NAS:ParkinsonsUK-UCL.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

RNF11_HUMAN RING finger protein 11
GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase.
GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.

SC6A3_HUMAN Sodium-dependent dopamine transporter
GO:0030424; C:axon; IDA:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0016600; C:flotillin complex; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0005329; F:dopamine transmembrane transporter activity; IDA:UniProtKB.
GO:0005330; F:dopamine:sodium symporter activity; IBA:GO_Central.
GO:0008144; F:drug binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008504; F:monoamine transmembrane transporter activity; IDA:MGI.
GO:0021984; P:adenohypophysis development; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO:0042420; P:dopamine catabolic process; IEA:Ensembl.
GO:0015872; P:dopamine transport; IDA:UniProtKB.
GO:0090494; P:dopamine uptake; IDA:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IBA:GO_Central.
GO:0007595; P:lactation; IEA:Ensembl.
GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO:0015844; P:monoamine transport; IDA:MGI.
GO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome.
GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO:0060134; P:prepulse inhibition; IEA:Ensembl.
GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051591; P:response to cAMP; IEA:Ensembl.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0045471; P:response to ethanol; IEA:Ensembl.
GO:0010039; P:response to iron ion; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.
GO:0007608; P:sensory perception of smell; IEA:Ensembl.


CANCER Linkages


#10 CARCINOMA contains 7 proteins

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030159; F:receptor signaling complex scaffold activity; IC:ParkinsonsUK-UCL.
GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.
GO:0000149; F:SNARE binding; IPI:ParkinsonsUK-UCL.
GO:0017075; F:syntaxin-1 binding; IPI:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IDA:BHF-UCL.
GO:0000187; P:activation of MAPK activity; IMP:ParkinsonsUK-UCL.
GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0019722; P:calcium-mediated signaling; IMP:ParkinsonsUK-UCL.
GO:0060070; P:canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0034613; P:cellular protein localization; ISS:ParkinsonsUK-UCL.
GO:1903351; P:cellular response to dopamine; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0009267; P:cellular response to starvation; IMP:ParkinsonsUK-UCL.
GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
GO:0006897; P:endocytosis; IMP:ParkinsonsUK-UCL.
GO:0060079; P:excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0035640; P:exploration behavior; IMP:BHF-UCL.
GO:0007030; P:Golgi organization; IMP:ParkinsonsUK-UCL.
GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.
GO:0035556; P:intracellular signal transduction; ISS:ParkinsonsUK-UCL.
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO:0007040; P:lysosome organization; IMP:ParkinsonsUK-UCL.
GO:0000165; P:MAPK cascade; IDA:UniProtKB.
GO:0051646; P:mitochondrion localization; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0034260; P:negative regulation of GTPase activity; IDA:MGI.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:ParkinsonsUK-UCL.
GO:0010955; P:negative regulation of protein processing; IDA:ParkinsonsUK-UCL.
GO:1903217; P:negative regulation of protein processing involved in protein targeting to mitochondrion; IC:ParkinsonsUK-UCL.
GO:1903215; P:negative regulation of protein targeting to mitochondrion; IDA:ParkinsonsUK-UCL.
GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.
GO:0070997; P:neuron death; IMP:BHF-UCL.
GO:0048812; P:neuron projection morphogenesis; IMP:UniProtKB.
GO:0021772; P:olfactory bulb development; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:0016310; P:phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IC:ParkinsonsUK-UCL.
GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:1902499; P:positive regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0072593; P:reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:ParkinsonsUK-UCL.
GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IMP:ParkinsonsUK-UCL.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL.
GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.
GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.
GO:0035751; P:regulation of lysosomal lumen pH; IMP:ParkinsonsUK-UCL.
GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.
GO:0051900; P:regulation of mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0090140; P:regulation of mitochondrial fission; TAS:ParkinsonsUK-UCL.
GO:1902692; P:regulation of neuroblast proliferation; IMP:ParkinsonsUK-UCL.
GO:1901214; P:regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO:0014041; P:regulation of neuron maturation; IMP:ParkinsonsUK-UCL.
GO:0010738; P:regulation of protein kinase A signaling; ISS:ParkinsonsUK-UCL.
GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IGI:ParkinsonsUK-UCL.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:ParkinsonsUK-UCL.
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:ParkinsonsUK-UCL.
GO:1904887; P:Wnt signalosome assembly; IPI:ParkinsonsUK-UCL.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


CARCINOMA Linkages


#11 CARDIOMYOPATHY contains 21 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
GO:0031305; C:integral component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IMP:UniProtKB.
GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-HAMAP.
GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB.

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.


CARDIOMYOPATHY Linkages


#12 CATARACT contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

FRIL_HUMAN Ferritin light chain
GO:0044754; C:autolysosome; IDA:MGI.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0008043; C:intracellular ferritin complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0008199; F:ferric iron binding; IEA:InterPro.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005506; F:iron ion binding; IDA:UniProtKB.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
GO:0055072; P:iron ion homeostasis; TAS:UniProtKB.
GO:0006826; P:iron ion transport; IEA:InterPro.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


CATARACT Linkages


#13 CIRRHOSIS contains 2 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

ZNT10_HUMAN Zinc transporter 10
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO:0006828; P:manganese ion transport; IMP:UniProtKB.
GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO:0010043; P:response to zinc ion; IBA:GO_Central.


CIRRHOSIS Linkages


#14 COLORECTAL contains 4 proteins

IF4G1_HUMAN Eukaryotic translation initiation factor 4
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:AgBase.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IMP:ParkinsonsUK-UCL.
GO:0005844; C:polysome; IMP:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:AgBase.
GO:0003729; F:mRNA binding; IDA:ParkinsonsUK-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0032947; F:protein complex scaffold; TAS:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; TAS:ParkinsonsUK-UCL.
GO:0008135; F:translation factor activity, RNA binding; IMP:ParkinsonsUK-UCL.
GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
GO:0031369; F:translation initiation factor binding; TAS:ParkinsonsUK-UCL.
GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO:0002191; P:cap-dependent translational initiation; TAS:ParkinsonsUK-UCL.
GO:0034645; P:cellular macromolecule biosynthetic process; IGI:ParkinsonsUK-UCL.
GO:0032502; P:developmental process; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
GO:0030307; P:positive regulation of cell growth; IMP:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:ParkinsonsUK-UCL.
GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:2000507; P:positive regulation of energy homeostasis; IMP:ParkinsonsUK-UCL.
GO:1905537; P:positive regulation of eukaryotic translation initiation factor 4F complex assembly; IMP:ParkinsonsUK-UCL.
GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:ParkinsonsUK-UCL.
GO:1905618; P:positive regulation of miRNA mediated inhibition of translation; IDA:ParkinsonsUK-UCL.
GO:1905612; P:positive regulation of mRNA cap binding; IDA:ParkinsonsUK-UCL.
GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0080135; P:regulation of cellular response to stress; TAS:ParkinsonsUK-UCL.
GO:0060964; P:regulation of gene silencing by miRNA; TAS:ParkinsonsUK-UCL.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
GO:0006412; P:translation; IMP:ParkinsonsUK-UCL.
GO:0006413; P:translational initiation; NAS:ParkinsonsUK-UCL.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.


COLORECTAL Linkages


#15 COPPER contains 4 proteins

CERU_HUMAN Ceruloplasmin
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0005507; F:copper ion binding; IEA:InterPro.
GO:0004322; F:ferroxidase activity; TAS:Reactome.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.


COPPER Linkages


#16 DEMENTIA contains 25 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

DJC13_HUMAN DnaJ homolog subfamily C member
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0007032; P:endosome organization; IMP:UniProtKB.
GO:0001649; P:osteoblast differentiation; IDA:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:2000641; P:regulation of early endosome to late endosome transport; IMP:UniProtKB.
GO:1902954; P:regulation of early endosome to recycling endosome transport; IMP:UniProtKB.

GLCM_HUMAN Glucosylceramidase
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IEA:Ensembl.
GO:0043202; C:lysosomal lumen; ISS:BHF-UCL.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0004348; F:glucosylceramidase activity; IDA:BHF-UCL.
GO:0005102; F:receptor binding; ISS:BHF-UCL.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.
GO:0046513; P:ceramide biosynthetic process; IMP:BHF-UCL.
GO:0006680; P:glucosylceramide catabolic process; IMP:BHF-UCL.
GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
GO:0032715; P:negative regulation of interleukin-6 production; IDA:BHF-UCL.
GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032463; P:negative regulation of protein homooligomerization; IDA:ParkinsonsUK-UCL.
GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
GO:1904457; P:positive regulation of neuronal action potential; IMP:ParkinsonsUK-UCL.
GO:0043243; P:positive regulation of protein complex disassembly; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IMP:BHF-UCL.
GO:1903061; P:positive regulation of protein lipidation; IGI:ParkinsonsUK-UCL.
GO:0051247; P:positive regulation of protein metabolic process; IGI:ParkinsonsUK-UCL.
GO:1903052; P:positive regulation of proteolysis involved in cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0032268; P:regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0033561; P:regulation of water loss via skin; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0009268; P:response to pH; IEA:Ensembl.
GO:0033574; P:response to testosterone; IEA:Ensembl.
GO:0097066; P:response to thyroid hormone; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0046512; P:sphingosine biosynthetic process; IMP:BHF-UCL.
GO:0023021; P:termination of signal transduction; IMP:BHF-UCL.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

PDGFB_HUMAN Platelet-derived growth factor subunit B
GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IBA:GO_Central.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
GO:0005518; F:collagen binding; IDA:MGI.
GO:0008083; F:growth factor activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0048407; F:platelet-derived growth factor binding; IPI:BHF-UCL.
GO:0005161; F:platelet-derived growth factor receptor binding; NAS:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; TAS:Reactome.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; IDA:BHF-UCL.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1905064; P:negative regulation of vascular smooth muscle cell differentiation; IDA:BHF-UCL.
GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090280; P:positive regulation of calcium ion import; IDA:UniProtKB.
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
GO:2000573; P:positive regulation of DNA biosynthetic process; IDA:UniProtKB.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO:1900127; P:positive regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; IDA:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IDA:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IDA:BHF-UCL.
GO:1905176; P:positive regulation of vascular smooth muscle cell dedifferentiation; IDA:BHF-UCL.
GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IDA:BHF-UCL.
GO:0070528; P:protein kinase C signaling; IMP:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
GO:0097449; C:astrocyte projection; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0031307; C:integral component of mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0055131; F:C3HC4-type RING finger domain binding; IPI:BHF-UCL.
GO:0010857; F:calcium-dependent protein kinase activity; IDA:BHF-UCL.
GO:0016301; F:kinase activity; NAS:ParkinsonsUK-UCL.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016504; F:peptidase activator activity; TAS:ParkinsonsUK-UCL.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IMP:ParkinsonsUK-UCL.
GO:0043422; F:protein kinase B binding; IDA:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0071456; P:cellular response to hypoxia; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; TAS:ParkinsonsUK-UCL.
GO:0072655; P:establishment of protein localization to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0072656; P:maintenance of protein location in mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; ISS:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903298; P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903751; P:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IDA:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0090258; P:negative regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:1903147; P:negative regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; TAS:ParkinsonsUK-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0036289; P:peptidyl-serine autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0016310; P:phosphorylation; NAS:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903852; P:positive regulation of cristae formation; IMP:ParkinsonsUK-UCL.
GO:0033603; P:positive regulation of dopamine secretion; IEA:Ensembl.
GO:1904544; P:positive regulation of free ubiquitin chain polymerization; ISS:ParkinsonsUK-UCL.
GO:1901727; P:positive regulation of histone deacetylase activity; IEA:Ensembl.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:BHF-UCL.
GO:0016239; P:positive regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IBA:GO_Central.
GO:0010952; P:positive regulation of peptidase activity; TAS:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:AgBase.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; ISS:ParkinsonsUK-UCL.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:BHF-UCL.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:1900407; P:regulation of cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0010310; P:regulation of hydrogen peroxide metabolic process; IEA:Ensembl.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0002082; P:regulation of oxidative phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0061136; P:regulation of proteasomal protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0043254; P:regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; IDA:AgBase.
GO:0031396; P:regulation of protein ubiquitination; IDA:BHF-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; TAS:ParkinsonsUK-UCL.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IGI:ParkinsonsUK-UCL.
GO:0006950; P:response to stress; IDA:UniProtKB.
GO:0038203; P:TORC2 signaling; IC:ParkinsonsUK-UCL.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

S20A2_HUMAN Sodium-dependent phosphate transporter 2
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
GO:0006811; P:ion transport; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.

SNCAP_HUMAN Synphilin-1
GO:0005737; C:cytoplasm; IDA:MGI.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043025; C:neuronal cell body; NAS:UniProtKB.
GO:0042734; C:presynaptic membrane; NAS:UniProtKB.
GO:0008021; C:synaptic vesicle; TAS:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008219; P:cell death; IDA:CACAO.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0042417; P:dopamine metabolic process; IDA:MGI.
GO:0090083; P:regulation of inclusion body assembly; IDA:BHF-UCL.
GO:0046928; P:regulation of neurotransmitter secretion; IDA:MGI.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

TERA_HUMAN Transitional endoplasmic reticulum ATPase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0036513; C:Derlin-1 retrotranslocation complex; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005811; C:lipid particle; IDA:MGI.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0000502; C:proteasome complex; IDA:BHF-UCL.
GO:0035861; C:site of double-strand break; IDA:UniProtKB.
GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; ISS:ParkinsonsUK-UCL.
GO:1990730; C:VCP-NSFL1C complex; ISS:ParkinsonsUK-UCL.
GO:0043531; F:ADP binding; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; IMP:UniProtKB.
GO:1904288; F:BAT3 complex binding; IPI:ParkinsonsUK-UCL.
GO:0035800; F:deubiquitinase activator activity; IDA:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.
GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0044389; F:ubiquitin-like protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO:0070842; P:aggresome assembly; IEA:Ensembl.
GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO:0097352; P:autophagosome maturation; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006302; P:double-strand break repair; IDA:UniProtKB.
GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0036503; P:ERAD pathway; IMP:UniProtKB.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0045184; P:establishment of protein localization; TAS:UniProtKB.
GO:0072389; P:flavin adenine dinucleotide catabolic process; IMP:ParkinsonsUK-UCL.
GO:0006734; P:NADH metabolic process; IMP:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903007; P:positive regulation of Lys63-specific deubiquitinase activity; IDA:ParkinsonsUK-UCL.
GO:0010918; P:positive regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:1903862; P:positive regulation of oxidative phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903006; P:positive regulation of protein K63-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0034214; P:protein hexamerization; IEA:Ensembl.
GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO:0018279; P:protein N-linked glycosylation via asparagine; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
GO:1903715; P:regulation of aerobic respiration; IMP:ParkinsonsUK-UCL.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IDA:UniProtKB.
GO:0019985; P:translesion synthesis; IMP:UniProtKB.
GO:0019079; P:viral genome replication; IMP:CACAO.

TM230_HUMAN Transmembrane protein 230
GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005770; C:late endosome; IDA:UniProtKB.
GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0036465; P:synaptic vesicle recycling; IMP:UniProtKB.

TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0035544; P:negative regulation of SNARE complex assembly; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0034045; C:pre-autophagosomal structure membrane; IBA:GO_Central.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0000422; P:mitophagy; IBA:GO_Central.
GO:0044804; P:nucleophagy; IBA:GO_Central.
GO:0006497; P:protein lipidation; IBA:GO_Central.
GO:0034497; P:protein localization to pre-autophagosomal structure; IBA:GO_Central.

XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
GO:0005794; C:Golgi apparatus; IBA:GO_Central.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0015562; F:efflux transmembrane transporter activity; IMP:UniProtKB.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0000822; F:inositol hexakisphosphate binding; IDA:UniProtKB.
GO:0015114; F:phosphate ion transmembrane transporter activity; IMP:UniProtKB.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IMP:UniProtKB.
GO:0030643; P:cellular phosphate ion homeostasis; IMP:UniProtKB.
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0035435; P:phosphate ion transmembrane transport; IMP:UniProtKB.
GO:0009615; P:response to virus; IEA:Ensembl.


DEMENTIA Linkages


#17 DEPRESSION contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

DCTN1_HUMAN Dynactin subunit 1
GO:0031252; C:cell leading edge; IEA:Ensembl.
GO:0005814; C:centriole; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005869; C:dynactin complex; IEA:InterPro.
GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0035371; C:microtubule plus-end; IDA:UniProtKB.
GO:0005635; C:nuclear envelope; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0000922; C:spindle pole; IDA:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0003774; F:motor activity; IEA:UniProtKB-KW.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0010457; P:centriole-centriole cohesion; IMP:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:Reactome.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0032402; P:melanosome transport; IEA:Ensembl.
GO:0034454; P:microtubule anchoring at centrosome; IMP:UniProtKB.
GO:0007067; P:mitotic nuclear division; NAS:ProtInc.
GO:0007399; P:nervous system development; NAS:UniProtKB.
GO:1905515; P:non-motile cilium assembly; IMP:UniProtKB.
GO:0051081; P:nuclear envelope disassembly; IMP:UniProtKB.
GO:0090063; P:positive regulation of microtubule nucleation; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
GO:0010970; P:transport along microtubule; IEA:InterPro.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


DEPRESSION Linkages


#18 DIABETES contains 3 proteins

CERU_HUMAN Ceruloplasmin
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0005507; F:copper ion binding; IEA:InterPro.
GO:0004322; F:ferroxidase activity; TAS:Reactome.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
GO:0005829; C:cytosol; TAS:Reactome.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:Reactome.
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway.
GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB.
GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO:0007165; P:signal transduction; IEA:InterPro.


DIABETES Linkages


#19 DIURNAL contains 2 proteins

PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
GO:0097449; C:astrocyte projection; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0031307; C:integral component of mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0055131; F:C3HC4-type RING finger domain binding; IPI:BHF-UCL.
GO:0010857; F:calcium-dependent protein kinase activity; IDA:BHF-UCL.
GO:0016301; F:kinase activity; NAS:ParkinsonsUK-UCL.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016504; F:peptidase activator activity; TAS:ParkinsonsUK-UCL.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IMP:ParkinsonsUK-UCL.
GO:0043422; F:protein kinase B binding; IDA:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0071456; P:cellular response to hypoxia; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; TAS:ParkinsonsUK-UCL.
GO:0072655; P:establishment of protein localization to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0072656; P:maintenance of protein location in mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; ISS:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903298; P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903751; P:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IDA:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0090258; P:negative regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:1903147; P:negative regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; TAS:ParkinsonsUK-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0036289; P:peptidyl-serine autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0016310; P:phosphorylation; NAS:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903852; P:positive regulation of cristae formation; IMP:ParkinsonsUK-UCL.
GO:0033603; P:positive regulation of dopamine secretion; IEA:Ensembl.
GO:1904544; P:positive regulation of free ubiquitin chain polymerization; ISS:ParkinsonsUK-UCL.
GO:1901727; P:positive regulation of histone deacetylase activity; IEA:Ensembl.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:BHF-UCL.
GO:0016239; P:positive regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IBA:GO_Central.
GO:0010952; P:positive regulation of peptidase activity; TAS:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:AgBase.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; ISS:ParkinsonsUK-UCL.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:BHF-UCL.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:1900407; P:regulation of cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0010310; P:regulation of hydrogen peroxide metabolic process; IEA:Ensembl.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0002082; P:regulation of oxidative phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0061136; P:regulation of proteasomal protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0043254; P:regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; IDA:AgBase.
GO:0031396; P:regulation of protein ubiquitination; IDA:BHF-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; TAS:ParkinsonsUK-UCL.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IGI:ParkinsonsUK-UCL.
GO:0006950; P:response to stress; IDA:UniProtKB.
GO:0038203; P:TORC2 signaling; IC:ParkinsonsUK-UCL.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.


DIURNAL Linkages


#20 DYSTONIA contains 18 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0044326; C:dendritic spine neck; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0042383; C:sarcolemma; IEA:Ensembl.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IC:UniProtKB.
GO:0045202; C:synapse; ISS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:UniProtKB.
GO:0086037; F:sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA:Ensembl.
GO:1990239; F:steroid hormone binding; NAS:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0015991; P:ATP hydrolysis coupled proton transport; IBA:GO_Central.
GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL.
GO:0071383; P:cellular response to steroid hormone stimulus; NAS:BHF-UCL.
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0010107; P:potassium ion import; IDA:BHF-UCL.
GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:1903416; P:response to glycoside; NAS:BHF-UCL.
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL.
GO:0008542; P:visual learning; IEA:Ensembl.

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

PDGFB_HUMAN Platelet-derived growth factor subunit B
GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IBA:GO_Central.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
GO:0005518; F:collagen binding; IDA:MGI.
GO:0008083; F:growth factor activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0048407; F:platelet-derived growth factor binding; IPI:BHF-UCL.
GO:0005161; F:platelet-derived growth factor receptor binding; NAS:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; TAS:Reactome.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; IDA:BHF-UCL.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1905064; P:negative regulation of vascular smooth muscle cell differentiation; IDA:BHF-UCL.
GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090280; P:positive regulation of calcium ion import; IDA:UniProtKB.
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
GO:2000573; P:positive regulation of DNA biosynthetic process; IDA:UniProtKB.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO:1900127; P:positive regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; IDA:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IDA:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IDA:BHF-UCL.
GO:1905176; P:positive regulation of vascular smooth muscle cell dedifferentiation; IDA:BHF-UCL.
GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IDA:BHF-UCL.
GO:0070528; P:protein kinase C signaling; IMP:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003725; F:double-stranded RNA binding; IDA:BHF-UCL.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO:0031047; P:gene silencing by RNA; TAS:Reactome.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0042473; P:outer ear morphogenesis; IEA:Ensembl.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0031054; P:pre-miRNA processing; IDA:BHF-UCL.
GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IDA:BHF-UCL.
GO:0030422; P:production of siRNA involved in RNA interference; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IEA:Ensembl.
GO:0009615; P:response to virus; TAS:ProtInc.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.

S20A2_HUMAN Sodium-dependent phosphate transporter 2
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
GO:0006811; P:ion transport; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.

S39AE_HUMAN Zinc transporter ZIP14
GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0016021; C:integral component of membrane; IDA:BHF-UCL.
GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:Ensembl.
GO:0005385; F:zinc ion transmembrane transporter activity; IDA:BHF-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
GO:0071578; P:zinc II ion transmembrane import; IDA:BHF-UCL.
GO:0071577; P:zinc II ion transmembrane transport; IMP:UniProtKB.

SC6A3_HUMAN Sodium-dependent dopamine transporter
GO:0030424; C:axon; IDA:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0016600; C:flotillin complex; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0005329; F:dopamine transmembrane transporter activity; IDA:UniProtKB.
GO:0005330; F:dopamine:sodium symporter activity; IBA:GO_Central.
GO:0008144; F:drug binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008504; F:monoamine transmembrane transporter activity; IDA:MGI.
GO:0021984; P:adenohypophysis development; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO:0042420; P:dopamine catabolic process; IEA:Ensembl.
GO:0015872; P:dopamine transport; IDA:UniProtKB.
GO:0090494; P:dopamine uptake; IDA:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IBA:GO_Central.
GO:0007595; P:lactation; IEA:Ensembl.
GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO:0015844; P:monoamine transport; IDA:MGI.
GO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome.
GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO:0060134; P:prepulse inhibition; IEA:Ensembl.
GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051591; P:response to cAMP; IEA:Ensembl.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0045471; P:response to ethanol; IEA:Ensembl.
GO:0010039; P:response to iron ion; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.
GO:0007608; P:sensory perception of smell; IEA:Ensembl.

SYNJ1_HUMAN Synaptojanin-1
GO:0030132; C:clathrin coat of coated pit; ISS:BHF-UCL.
GO:0005829; C:cytosol; ISS:ParkinsonsUK-UCL.
GO:0030117; C:membrane coat; ISS:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IDA:ParkinsonsUK-UCL.
GO:0097060; C:synaptic membrane; ISS:BHF-UCL.
GO:0043195; C:terminal bouton; ISS:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; ISS:ParkinsonsUK-UCL.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0034596; F:phosphatidylinositol phosphate 4-phosphatase activity; TAS:Reactome.
GO:0034595; F:phosphatidylinositol phosphate 5-phosphatase activity; ISS:ParkinsonsUK-UCL.
GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; TAS:Reactome.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046855; P:inositol phosphate dephosphorylation; ISS:ParkinsonsUK-UCL.
GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
GO:0007612; P:learning; IMP:ParkinsonsUK-UCL.
GO:0006836; P:neurotransmitter transport; ISS:ParkinsonsUK-UCL.
GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:ParkinsonsUK-UCL.
GO:0046488; P:phosphatidylinositol metabolic process; ISS:ParkinsonsUK-UCL.
GO:1904980; P:positive regulation of endosome organization; IMP:ParkinsonsUK-UCL.
GO:0048488; P:synaptic vesicle endocytosis; IGI:ParkinsonsUK-UCL.
GO:0016082; P:synaptic vesicle priming; ISS:ParkinsonsUK-UCL.
GO:0048489; P:synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0016191; P:synaptic vesicle uncoating; ISS:ParkinsonsUK-UCL.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

TY3H_HUMAN Tyrosine 3-monooxygenase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0033162; C:melanosome membrane; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:BHF-UCL.
GO:0005634; C:nucleus; ISS:BHF-UCL.
GO:0043204; C:perikaryon; ISS:BHF-UCL.
GO:0005790; C:smooth endoplasmic reticulum; IDA:BHF-UCL.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0016597; F:amino acid binding; IEA:Ensembl.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008199; F:ferric iron binding; IEA:Ensembl.
GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO:0019825; F:oxygen binding; IEA:Ensembl.
GO:0034617; F:tetrahydrobiopterin binding; IEA:Ensembl.
GO:0004511; F:tyrosine 3-monooxygenase activity; IDA:UniProtKB.
GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IEA:Ensembl.
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO:0009887; P:animal organ morphogenesis; ISS:BHF-UCL.
GO:0042423; P:catecholamine biosynthetic process; TAS:Reactome.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO:0071287; P:cellular response to manganese ion; IEA:Ensembl.
GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO:0042745; P:circadian sleep/wake cycle; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IDA:BHF-UCL.
GO:0006585; P:dopamine biosynthetic process from tyrosine; NAS:BHF-UCL.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048596; P:embryonic camera-type eye morphogenesis; ISS:BHF-UCL.
GO:0042418; P:epinephrine biosynthetic process; IDA:BHF-UCL.
GO:0042462; P:eye photoreceptor cell development; ISS:BHF-UCL.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0016137; P:glycoside metabolic process; IEA:Ensembl.
GO:0007507; P:heart development; ISS:BHF-UCL.
GO:0003007; P:heart morphogenesis; NAS:BHF-UCL.
GO:0033076; P:isoquinoline alkaloid metabolic process; IEA:Ensembl.
GO:0007612; P:learning; ISS:BHF-UCL.
GO:0007626; P:locomotory behavior; ISS:BHF-UCL.
GO:0007617; P:mating behavior; IEA:Ensembl.
GO:0007613; P:memory; ISS:BHF-UCL.
GO:0010259; P:multicellular organism aging; IEA:Ensembl.
GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
GO:0042421; P:norepinephrine biosynthetic process; IDA:BHF-UCL.
GO:0018963; P:phthalate metabolic process; IEA:Ensembl.
GO:0052314; P:phytoalexin metabolic process; IEA:Ensembl.
GO:0043473; P:pigmentation; TAS:BHF-UCL.
GO:0008016; P:regulation of heart contraction; ISS:BHF-UCL.
GO:0014823; P:response to activity; IEA:Ensembl.
GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0045471; P:response to ethanol; IDA:BHF-UCL.
GO:0045472; P:response to ether; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IDA:BHF-UCL.
GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO:0035900; P:response to isolation stress; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0031667; P:response to nutrient levels; IEA:Ensembl.
GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO:0046684; P:response to pyrethroid; IEA:Ensembl.
GO:0009651; P:response to salt stress; IEA:Ensembl.
GO:0009414; P:response to water deprivation; IEA:Ensembl.
GO:0010043; P:response to zinc ion; IEA:Ensembl.
GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO:0035176; P:social behavior; IEA:Ensembl.
GO:0006665; P:sphingolipid metabolic process; IEA:Ensembl.
GO:0001963; P:synaptic transmission, dopaminergic; ISS:BHF-UCL.
GO:0042214; P:terpene metabolic process; IEA:Ensembl.
GO:0007601; P:visual perception; ISS:BHF-UCL.

WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0034045; C:pre-autophagosomal structure membrane; IBA:GO_Central.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0000422; P:mitophagy; IBA:GO_Central.
GO:0044804; P:nucleophagy; IBA:GO_Central.
GO:0006497; P:protein lipidation; IBA:GO_Central.
GO:0034497; P:protein localization to pre-autophagosomal structure; IBA:GO_Central.

XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
GO:0005794; C:Golgi apparatus; IBA:GO_Central.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0015562; F:efflux transmembrane transporter activity; IMP:UniProtKB.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0000822; F:inositol hexakisphosphate binding; IDA:UniProtKB.
GO:0015114; F:phosphate ion transmembrane transporter activity; IMP:UniProtKB.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IMP:UniProtKB.
GO:0030643; P:cellular phosphate ion homeostasis; IMP:UniProtKB.
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0035435; P:phosphate ion transmembrane transport; IMP:UniProtKB.
GO:0009615; P:response to virus; IEA:Ensembl.

ZNT10_HUMAN Zinc transporter 10
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO:0006828; P:manganese ion transport; IMP:UniProtKB.
GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO:0010043; P:response to zinc ion; IBA:GO_Central.


DYSTONIA Linkages


#21 EXTRAPYRAMIDAL contains 7 proteins

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0034045; C:pre-autophagosomal structure membrane; IBA:GO_Central.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0000422; P:mitophagy; IBA:GO_Central.
GO:0044804; P:nucleophagy; IBA:GO_Central.
GO:0006497; P:protein lipidation; IBA:GO_Central.
GO:0034497; P:protein localization to pre-autophagosomal structure; IBA:GO_Central.

ZNT10_HUMAN Zinc transporter 10
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO:0006828; P:manganese ion transport; IMP:UniProtKB.
GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO:0010043; P:response to zinc ion; IBA:GO_Central.


EXTRAPYRAMIDAL Linkages


#22 FATIGABILITY contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


FATIGABILITY Linkages


#23 FINGER contains 7 proteins

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
GO:0005813; C:centrosome; TAS:UniProtKB.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000226; P:microtubule cytoskeleton organization; TAS:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central.

RNF11_HUMAN RING finger protein 11
GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase.
GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0035544; P:negative regulation of SNARE complex assembly; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.

VPS41_HUMAN Vacuolar protein sorting-associated protein 41
GO:0030123; C:AP-3 adaptor complex; IEA:Ensembl.
GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.
GO:0033263; C:CORVET complex; IBA:GO_Central.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IMP:UniProtKB.
GO:0030897; C:HOPS complex; IDA:UniProtKB.
GO:0031902; C:late endosome membrane; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0051020; F:GTPase binding; IBA:GO_Central.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0034058; P:endosomal vesicle fusion; IMP:UniProtKB.
GO:0008333; P:endosome to lysosome transport; IMP:UniProtKB.
GO:0048193; P:Golgi vesicle transport; IMP:UniProtKB.
GO:1902774; P:late endosome to lysosome transport; IMP:UniProtKB.
GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
GO:0045055; P:regulated exocytosis; IEA:Ensembl.
GO:0035542; P:regulation of SNARE complex assembly; IBA:GO_Central.
GO:0042144; P:vacuole fusion, non-autophagic; IBA:GO_Central.

ZN746_HUMAN Zinc finger protein 746
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005634; C:nucleus; IC:ParkinsonsUK-UCL.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1901216; P:positive regulation of neuron death; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.


FINGER Linkages


#24 GASTR contains 5 proteins

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

HRH2_HUMAN Histamine H2 receptor
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004969; F:histamine receptor activity; TAS:ProtInc.
GO:0048565; P:digestive tract development; IEA:Ensembl.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl.
GO:0048732; P:gland development; IEA:Ensembl.
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0007613; P:memory; IEA:Ensembl.
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:1901998; P:toxin transport; IEA:Ensembl.
GO:0008542; P:visual learning; IEA:Ensembl.

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


GASTR Linkages


#25 GLUCOSE contains 4 proteins

CPLX1_HUMAN Complexin-1
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Ensembl.
GO:0070554; C:synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; TAS:ParkinsonsUK-UCL.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0005326; F:neurotransmitter transporter activity; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
GO:0006887; P:exocytosis; TAS:ProtInc.
GO:0014047; P:glutamate secretion; TAS:Reactome.
GO:0030073; P:insulin secretion; IEA:Ensembl.
GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
GO:0017157; P:regulation of exocytosis; TAS:ParkinsonsUK-UCL.
GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.

GLCM_HUMAN Glucosylceramidase
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IEA:Ensembl.
GO:0043202; C:lysosomal lumen; ISS:BHF-UCL.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0004348; F:glucosylceramidase activity; IDA:BHF-UCL.
GO:0005102; F:receptor binding; ISS:BHF-UCL.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.
GO:0046513; P:ceramide biosynthetic process; IMP:BHF-UCL.
GO:0006680; P:glucosylceramide catabolic process; IMP:BHF-UCL.
GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
GO:0032715; P:negative regulation of interleukin-6 production; IDA:BHF-UCL.
GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032463; P:negative regulation of protein homooligomerization; IDA:ParkinsonsUK-UCL.
GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
GO:1904457; P:positive regulation of neuronal action potential; IMP:ParkinsonsUK-UCL.
GO:0043243; P:positive regulation of protein complex disassembly; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IMP:BHF-UCL.
GO:1903061; P:positive regulation of protein lipidation; IGI:ParkinsonsUK-UCL.
GO:0051247; P:positive regulation of protein metabolic process; IGI:ParkinsonsUK-UCL.
GO:1903052; P:positive regulation of proteolysis involved in cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0032268; P:regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0033561; P:regulation of water loss via skin; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0009268; P:response to pH; IEA:Ensembl.
GO:0033574; P:response to testosterone; IEA:Ensembl.
GO:0097066; P:response to thyroid hormone; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0046512; P:sphingosine biosynthetic process; IMP:BHF-UCL.
GO:0023021; P:termination of signal transduction; IMP:BHF-UCL.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.


GLUCOSE Linkages


#26 HEPARAN contains 4 proteins

CERU_HUMAN Ceruloplasmin
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0005507; F:copper ion binding; IEA:InterPro.
GO:0004322; F:ferroxidase activity; TAS:Reactome.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.

FGF20_HUMAN Fibroblast growth factor 20
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005622; C:intracellular; IEA:GOC.
GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:Reactome.
GO:0008083; F:growth factor activity; ISS:ParkinsonsUK-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; TAS:ParkinsonsUK-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; TAS:ParkinsonsUK-UCL.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0008284; P:positive regulation of cell proliferation; TAS:ParkinsonsUK-UCL.
GO:1904340; P:positive regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO:0060043; P:regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.

KLK6_HUMAN Kallikrein-6
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0045171; C:intercellular bridge; IDA:HPA.
GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0042982; P:amyloid precursor protein metabolic process; NAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.
GO:0030574; P:collagen catabolic process; NAS:UniProtKB.
GO:0042445; P:hormone metabolic process; NAS:UniProtKB.
GO:0042552; P:myelination; NAS:UniProtKB.
GO:0070997; P:neuron death; IMP:UniProtKB.
GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
GO:0016540; P:protein autoprocessing; NAS:UniProtKB.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0045595; P:regulation of cell differentiation; NAS:UniProtKB.
GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0042246; P:tissue regeneration; NAS:UniProtKB.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.


HEPARAN Linkages


#27 HYPERREFLEXIA contains 3 proteins

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

FBX7_HUMAN F-box only protein 7
GO:0097414; C:classical Lewy body; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0097409; C:glial cytoplasmic inclusion; IDA:ParkinsonsUK-UCL.
GO:1990037; C:Lewy body core; IDA:ParkinsonsUK-UCL.
GO:1990038; C:Lewy body corona; IDA:ParkinsonsUK-UCL.
GO:0097462; C:Lewy neurite; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0043234; C:protein complex; IDA:LIFEdb.
GO:0019005; C:SCF ubiquitin ligase complex; TAS:ParkinsonsUK-UCL.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0004842; F:ubiquitin-protein transferase activity; TAS:ProtInc.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO:0045620; P:negative regulation of lymphocyte differentiation; IEA:Ensembl.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; IDA:ParkinsonsUK-UCL.
GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0040012; P:regulation of locomotion; IDA:ParkinsonsUK-UCL.
GO:0010975; P:regulation of neuron projection development; IMP:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IDA:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
GO:0097449; C:astrocyte projection; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0031307; C:integral component of mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0055131; F:C3HC4-type RING finger domain binding; IPI:BHF-UCL.
GO:0010857; F:calcium-dependent protein kinase activity; IDA:BHF-UCL.
GO:0016301; F:kinase activity; NAS:ParkinsonsUK-UCL.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016504; F:peptidase activator activity; TAS:ParkinsonsUK-UCL.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IMP:ParkinsonsUK-UCL.
GO:0043422; F:protein kinase B binding; IDA:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0071456; P:cellular response to hypoxia; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; TAS:ParkinsonsUK-UCL.
GO:0072655; P:establishment of protein localization to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0072656; P:maintenance of protein location in mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; ISS:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903298; P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903751; P:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IDA:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0090258; P:negative regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:1903147; P:negative regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; TAS:ParkinsonsUK-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0036289; P:peptidyl-serine autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0016310; P:phosphorylation; NAS:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903852; P:positive regulation of cristae formation; IMP:ParkinsonsUK-UCL.
GO:0033603; P:positive regulation of dopamine secretion; IEA:Ensembl.
GO:1904544; P:positive regulation of free ubiquitin chain polymerization; ISS:ParkinsonsUK-UCL.
GO:1901727; P:positive regulation of histone deacetylase activity; IEA:Ensembl.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:BHF-UCL.
GO:0016239; P:positive regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IBA:GO_Central.
GO:0010952; P:positive regulation of peptidase activity; TAS:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:AgBase.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; ISS:ParkinsonsUK-UCL.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:BHF-UCL.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:1900407; P:regulation of cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0010310; P:regulation of hydrogen peroxide metabolic process; IEA:Ensembl.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0002082; P:regulation of oxidative phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0061136; P:regulation of proteasomal protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0043254; P:regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; IDA:AgBase.
GO:0031396; P:regulation of protein ubiquitination; IDA:BHF-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; TAS:ParkinsonsUK-UCL.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IGI:ParkinsonsUK-UCL.
GO:0006950; P:response to stress; IDA:UniProtKB.
GO:0038203; P:TORC2 signaling; IC:ParkinsonsUK-UCL.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.


HYPERREFLEXIA Linkages


#28 HYPOGONADISM contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


HYPOGONADISM Linkages


#29 HYPOREFLEXIA contains 1 protein

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.


HYPOREFLEXIA Linkages


#30 HYPOVENTILATION contains 1 protein

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


HYPOVENTILATION Linkages


#31 INSOMNIA contains 1 protein

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.


INSOMNIA Linkages


#32 IRON contains 20 proteins

CERU_HUMAN Ceruloplasmin
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0005507; F:copper ion binding; IEA:InterPro.
GO:0004322; F:ferroxidase activity; TAS:Reactome.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

DJC13_HUMAN DnaJ homolog subfamily C member
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0007032; P:endosome organization; IMP:UniProtKB.
GO:0001649; P:osteoblast differentiation; IDA:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:2000641; P:regulation of early endosome to late endosome transport; IMP:UniProtKB.
GO:1902954; P:regulation of early endosome to recycling endosome transport; IMP:UniProtKB.

FRIL_HUMAN Ferritin light chain
GO:0044754; C:autolysosome; IDA:MGI.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0008043; C:intracellular ferritin complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0008199; F:ferric iron binding; IEA:InterPro.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005506; F:iron ion binding; IDA:UniProtKB.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
GO:0055072; P:iron ion homeostasis; TAS:UniProtKB.
GO:0006826; P:iron ion transport; IEA:InterPro.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.

PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005261; F:cation channel activity; ISS:UniProtKB.
GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro.
GO:0006812; P:cation transport; ISS:UniProtKB.
GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IMP:UniProtKB.
GO:0033625; P:positive regulation of integrin activation; IMP:UniProtKB.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

S39AE_HUMAN Zinc transporter ZIP14
GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0016021; C:integral component of membrane; IDA:BHF-UCL.
GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:Ensembl.
GO:0005385; F:zinc ion transmembrane transporter activity; IDA:BHF-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
GO:0071578; P:zinc II ion transmembrane import; IDA:BHF-UCL.
GO:0071577; P:zinc II ion transmembrane transport; IMP:UniProtKB.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TM230_HUMAN Transmembrane protein 230
GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005770; C:late endosome; IDA:UniProtKB.
GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0036465; P:synaptic vesicle recycling; IMP:UniProtKB.

TY3H_HUMAN Tyrosine 3-monooxygenase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0033162; C:melanosome membrane; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:BHF-UCL.
GO:0005634; C:nucleus; ISS:BHF-UCL.
GO:0043204; C:perikaryon; ISS:BHF-UCL.
GO:0005790; C:smooth endoplasmic reticulum; IDA:BHF-UCL.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0016597; F:amino acid binding; IEA:Ensembl.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008199; F:ferric iron binding; IEA:Ensembl.
GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO:0019825; F:oxygen binding; IEA:Ensembl.
GO:0034617; F:tetrahydrobiopterin binding; IEA:Ensembl.
GO:0004511; F:tyrosine 3-monooxygenase activity; IDA:UniProtKB.
GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IEA:Ensembl.
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO:0009887; P:animal organ morphogenesis; ISS:BHF-UCL.
GO:0042423; P:catecholamine biosynthetic process; TAS:Reactome.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO:0071287; P:cellular response to manganese ion; IEA:Ensembl.
GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO:0042745; P:circadian sleep/wake cycle; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IDA:BHF-UCL.
GO:0006585; P:dopamine biosynthetic process from tyrosine; NAS:BHF-UCL.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048596; P:embryonic camera-type eye morphogenesis; ISS:BHF-UCL.
GO:0042418; P:epinephrine biosynthetic process; IDA:BHF-UCL.
GO:0042462; P:eye photoreceptor cell development; ISS:BHF-UCL.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0016137; P:glycoside metabolic process; IEA:Ensembl.
GO:0007507; P:heart development; ISS:BHF-UCL.
GO:0003007; P:heart morphogenesis; NAS:BHF-UCL.
GO:0033076; P:isoquinoline alkaloid metabolic process; IEA:Ensembl.
GO:0007612; P:learning; ISS:BHF-UCL.
GO:0007626; P:locomotory behavior; ISS:BHF-UCL.
GO:0007617; P:mating behavior; IEA:Ensembl.
GO:0007613; P:memory; ISS:BHF-UCL.
GO:0010259; P:multicellular organism aging; IEA:Ensembl.
GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
GO:0042421; P:norepinephrine biosynthetic process; IDA:BHF-UCL.
GO:0018963; P:phthalate metabolic process; IEA:Ensembl.
GO:0052314; P:phytoalexin metabolic process; IEA:Ensembl.
GO:0043473; P:pigmentation; TAS:BHF-UCL.
GO:0008016; P:regulation of heart contraction; ISS:BHF-UCL.
GO:0014823; P:response to activity; IEA:Ensembl.
GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0045471; P:response to ethanol; IDA:BHF-UCL.
GO:0045472; P:response to ether; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IDA:BHF-UCL.
GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO:0035900; P:response to isolation stress; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0031667; P:response to nutrient levels; IEA:Ensembl.
GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO:0046684; P:response to pyrethroid; IEA:Ensembl.
GO:0009651; P:response to salt stress; IEA:Ensembl.
GO:0009414; P:response to water deprivation; IEA:Ensembl.
GO:0010043; P:response to zinc ion; IEA:Ensembl.
GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO:0035176; P:social behavior; IEA:Ensembl.
GO:0006665; P:sphingolipid metabolic process; IEA:Ensembl.
GO:0001963; P:synaptic transmission, dopaminergic; ISS:BHF-UCL.
GO:0042214; P:terpene metabolic process; IEA:Ensembl.
GO:0007601; P:visual perception; ISS:BHF-UCL.

WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0034045; C:pre-autophagosomal structure membrane; IBA:GO_Central.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0000422; P:mitophagy; IBA:GO_Central.
GO:0044804; P:nucleophagy; IBA:GO_Central.
GO:0006497; P:protein lipidation; IBA:GO_Central.
GO:0034497; P:protein localization to pre-autophagosomal structure; IBA:GO_Central.


IRON Linkages


#33 LACTIC contains 5 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


LACTIC Linkages


#34 LEBER contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.


LEBER Linkages


#35 LEIGH contains 20 proteins

COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
GO:0031305; C:integral component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IMP:UniProtKB.
GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-HAMAP.
GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.


LEIGH Linkages


#36 LEUKEMIA contains 3 proteins

PGFRB_HUMAN Platelet-derived growth factor receptor beta
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019899; F:enzyme binding; IPI:BHF-UCL.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
GO:0005161; F:platelet-derived growth factor receptor binding; IPI:BHF-UCL.
GO:0005017; F:platelet-derived growth factor-activated receptor activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL.
GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.
GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
GO:0048839; P:inner ear development; IEA:Ensembl.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
GO:0035789; P:metanephric mesenchymal cell migration; IEA:Ensembl.
GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO:2000491; P:positive regulation of hepatic stellate cell activation; IEA:Ensembl.
GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
GO:0007165; P:signal transduction; IDA:UniProtKB.
GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
GO:0042060; P:wound healing; IEA:Ensembl.

S20A2_HUMAN Sodium-dependent phosphate transporter 2
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; TAS:Reactome.
GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
GO:0006811; P:ion transport; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.

XPR1_HUMAN Xenotropic and polytropic retrovirus receptor
GO:0005794; C:Golgi apparatus; IBA:GO_Central.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
GO:0015562; F:efflux transmembrane transporter activity; IMP:UniProtKB.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0000822; F:inositol hexakisphosphate binding; IDA:UniProtKB.
GO:0015114; F:phosphate ion transmembrane transporter activity; IMP:UniProtKB.
GO:0004872; F:receptor activity; TAS:ProtInc.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0001618; F:virus receptor activity; IMP:UniProtKB.
GO:0030643; P:cellular phosphate ion homeostasis; IMP:UniProtKB.
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0035435; P:phosphate ion transmembrane transport; IMP:UniProtKB.
GO:0009615; P:response to virus; IEA:Ensembl.


LEUKEMIA Linkages


#37 LEUKODYSTROPHY contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.


LEUKODYSTROPHY Linkages


#38 LEVODOPA contains 11 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin
GO:0005829; C:cytosol; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0031982; C:vesicle; IBA:GO_Central.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
GO:2000369; P:regulation of clathrin-dependent endocytosis; IEA:Ensembl.
GO:0016191; P:synaptic vesicle uncoating; ISS:BHF-UCL.

CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0007005; P:mitochondrion organization; IBA:GO_Central.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:1900037; P:regulation of cellular response to hypoxia; IDA:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

HTRA2_HUMAN Serine protease HTRA2, mitochondrial
GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB.
GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB.
GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0044257; P:cellular protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB.
GO:0034605; P:cellular response to heat; IDA:UniProtKB.
GO:0035458; P:cellular response to interferon-beta; IDA:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071300; P:cellular response to retinoic acid; IDA:ParkinsonsUK-UCL.
GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0016540; P:protein autoprocessing; TAS:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.

IF4G1_HUMAN Eukaryotic translation initiation factor 4
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:AgBase.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IMP:ParkinsonsUK-UCL.
GO:0005844; C:polysome; IMP:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:AgBase.
GO:0003729; F:mRNA binding; IDA:ParkinsonsUK-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0032947; F:protein complex scaffold; TAS:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; TAS:ParkinsonsUK-UCL.
GO:0008135; F:translation factor activity, RNA binding; IMP:ParkinsonsUK-UCL.
GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
GO:0031369; F:translation initiation factor binding; TAS:ParkinsonsUK-UCL.
GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO:0002191; P:cap-dependent translational initiation; TAS:ParkinsonsUK-UCL.
GO:0034645; P:cellular macromolecule biosynthetic process; IGI:ParkinsonsUK-UCL.
GO:0032502; P:developmental process; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
GO:0030307; P:positive regulation of cell growth; IMP:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:ParkinsonsUK-UCL.
GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:2000507; P:positive regulation of energy homeostasis; IMP:ParkinsonsUK-UCL.
GO:1905537; P:positive regulation of eukaryotic translation initiation factor 4F complex assembly; IMP:ParkinsonsUK-UCL.
GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:ParkinsonsUK-UCL.
GO:1905618; P:positive regulation of miRNA mediated inhibition of translation; IDA:ParkinsonsUK-UCL.
GO:1905612; P:positive regulation of mRNA cap binding; IDA:ParkinsonsUK-UCL.
GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0080135; P:regulation of cellular response to stress; TAS:ParkinsonsUK-UCL.
GO:0060964; P:regulation of gene silencing by miRNA; TAS:ParkinsonsUK-UCL.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
GO:0006412; P:translation; IMP:ParkinsonsUK-UCL.
GO:0006413; P:translational initiation; NAS:ParkinsonsUK-UCL.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PERQ2_HUMAN PERQ amino acid-rich with GYF
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; IEA:Ensembl.
GO:0007631; P:feeding behavior; IEA:Ensembl.
GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:Ensembl.
GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO:0050881; P:musculoskeletal movement; IEA:Ensembl.
GO:0017148; P:negative regulation of translation; IMP:MGI.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.

SYNJ1_HUMAN Synaptojanin-1
GO:0030132; C:clathrin coat of coated pit; ISS:BHF-UCL.
GO:0005829; C:cytosol; ISS:ParkinsonsUK-UCL.
GO:0030117; C:membrane coat; ISS:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IDA:ParkinsonsUK-UCL.
GO:0097060; C:synaptic membrane; ISS:BHF-UCL.
GO:0043195; C:terminal bouton; ISS:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; ISS:ParkinsonsUK-UCL.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0034596; F:phosphatidylinositol phosphate 4-phosphatase activity; TAS:Reactome.
GO:0034595; F:phosphatidylinositol phosphate 5-phosphatase activity; ISS:ParkinsonsUK-UCL.
GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; TAS:Reactome.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046855; P:inositol phosphate dephosphorylation; ISS:ParkinsonsUK-UCL.
GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
GO:0007612; P:learning; IMP:ParkinsonsUK-UCL.
GO:0006836; P:neurotransmitter transport; ISS:ParkinsonsUK-UCL.
GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:ParkinsonsUK-UCL.
GO:0046488; P:phosphatidylinositol metabolic process; ISS:ParkinsonsUK-UCL.
GO:1904980; P:positive regulation of endosome organization; IMP:ParkinsonsUK-UCL.
GO:0048488; P:synaptic vesicle endocytosis; IGI:ParkinsonsUK-UCL.
GO:0016082; P:synaptic vesicle priming; ISS:ParkinsonsUK-UCL.
GO:0048489; P:synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0016191; P:synaptic vesicle uncoating; ISS:ParkinsonsUK-UCL.

TY3H_HUMAN Tyrosine 3-monooxygenase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0033162; C:melanosome membrane; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:BHF-UCL.
GO:0005634; C:nucleus; ISS:BHF-UCL.
GO:0043204; C:perikaryon; ISS:BHF-UCL.
GO:0005790; C:smooth endoplasmic reticulum; IDA:BHF-UCL.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0016597; F:amino acid binding; IEA:Ensembl.
GO:0035240; F:dopamine binding; IEA:Ensembl.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008199; F:ferric iron binding; IEA:Ensembl.
GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO:0019825; F:oxygen binding; IEA:Ensembl.
GO:0034617; F:tetrahydrobiopterin binding; IEA:Ensembl.
GO:0004511; F:tyrosine 3-monooxygenase activity; IDA:UniProtKB.
GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IEA:Ensembl.
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO:0009887; P:animal organ morphogenesis; ISS:BHF-UCL.
GO:0042423; P:catecholamine biosynthetic process; TAS:Reactome.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO:0071287; P:cellular response to manganese ion; IEA:Ensembl.
GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO:0042745; P:circadian sleep/wake cycle; IEA:Ensembl.
GO:0042416; P:dopamine biosynthetic process; IDA:BHF-UCL.
GO:0006585; P:dopamine biosynthetic process from tyrosine; NAS:BHF-UCL.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048596; P:embryonic camera-type eye morphogenesis; ISS:BHF-UCL.
GO:0042418; P:epinephrine biosynthetic process; IDA:BHF-UCL.
GO:0042462; P:eye photoreceptor cell development; ISS:BHF-UCL.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0016137; P:glycoside metabolic process; IEA:Ensembl.
GO:0007507; P:heart development; ISS:BHF-UCL.
GO:0003007; P:heart morphogenesis; NAS:BHF-UCL.
GO:0033076; P:isoquinoline alkaloid metabolic process; IEA:Ensembl.
GO:0007612; P:learning; ISS:BHF-UCL.
GO:0007626; P:locomotory behavior; ISS:BHF-UCL.
GO:0007617; P:mating behavior; IEA:Ensembl.
GO:0007613; P:memory; ISS:BHF-UCL.
GO:0010259; P:multicellular organism aging; IEA:Ensembl.
GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
GO:0042421; P:norepinephrine biosynthetic process; IDA:BHF-UCL.
GO:0018963; P:phthalate metabolic process; IEA:Ensembl.
GO:0052314; P:phytoalexin metabolic process; IEA:Ensembl.
GO:0043473; P:pigmentation; TAS:BHF-UCL.
GO:0008016; P:regulation of heart contraction; ISS:BHF-UCL.
GO:0014823; P:response to activity; IEA:Ensembl.
GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0045471; P:response to ethanol; IDA:BHF-UCL.
GO:0045472; P:response to ether; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IDA:BHF-UCL.
GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO:0035900; P:response to isolation stress; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0031667; P:response to nutrient levels; IEA:Ensembl.
GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO:0046684; P:response to pyrethroid; IEA:Ensembl.
GO:0009651; P:response to salt stress; IEA:Ensembl.
GO:0009414; P:response to water deprivation; IEA:Ensembl.
GO:0010043; P:response to zinc ion; IEA:Ensembl.
GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO:0035176; P:social behavior; IEA:Ensembl.
GO:0006665; P:sphingolipid metabolic process; IEA:Ensembl.
GO:0001963; P:synaptic transmission, dopaminergic; ISS:BHF-UCL.
GO:0042214; P:terpene metabolic process; IEA:Ensembl.
GO:0007601; P:visual perception; ISS:BHF-UCL.

VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
GO:0005737; C:cytoplasm; TAS:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0006895; P:Golgi to endosome transport; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1905090; P:negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.

VPS35_HUMAN Vacuolar protein sorting-associated protein 35
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:ParkinsonsUK-UCL.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005770; C:late endosome; IBA:GO_Central.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0099073; C:mitochondrion-derived vesicle; IDA:ParkinsonsUK-UCL.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0030904; C:retromer complex; IDA:ParkinsonsUK-UCL.
GO:0030906; C:retromer, cargo-selective complex; IDA:ParkinsonsUK-UCL.
GO:0097422; C:tubular endosome; IDA:UniProtKB.
GO:0031748; F:D1 dopamine receptor binding; IPI:ParkinsonsUK-UCL.
GO:0008565; F:protein transporter activity; IBA:GO_Central.
GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; IMP:UniProtKB.
GO:0099639; P:neurotransmitter receptor transport, endosome to plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO:1903364; P:positive regulation of cellular protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0061357; P:positive regulation of Wnt protein secretion; IEA:Ensembl.
GO:0032268; P:regulation of cellular protein metabolic process; IDA:ParkinsonsUK-UCL.
GO:1902950; P:regulation of dendritic spine maintenance; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IGI:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:2000331; P:regulation of terminal button organization; IMP:ParkinsonsUK-UCL.
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
GO:1990126; P:retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
GO:0045056; P:transcytosis; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; NAS:ParkinsonsUK-UCL.


LEVODOPA Linkages


#39 LEWY contains 26 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome.
GO:0060510; P:Type II pneumocyte differentiation; IEA:Ensembl.

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin
GO:0005829; C:cytosol; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0031982; C:vesicle; IBA:GO_Central.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
GO:2000369; P:regulation of clathrin-dependent endocytosis; IEA:Ensembl.
GO:0016191; P:synaptic vesicle uncoating; ISS:BHF-UCL.

CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0007005; P:mitochondrion organization; IBA:GO_Central.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:1900037; P:regulation of cellular response to hypoxia; IDA:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

DJC13_HUMAN DnaJ homolog subfamily C member
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0007032; P:endosome organization; IMP:UniProtKB.
GO:0001649; P:osteoblast differentiation; IDA:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:2000641; P:regulation of early endosome to late endosome transport; IMP:UniProtKB.
GO:1902954; P:regulation of early endosome to recycling endosome transport; IMP:UniProtKB.

GLCM_HUMAN Glucosylceramidase
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IEA:Ensembl.
GO:0043202; C:lysosomal lumen; ISS:BHF-UCL.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0004348; F:glucosylceramidase activity; IDA:BHF-UCL.
GO:0005102; F:receptor binding; ISS:BHF-UCL.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.
GO:0046513; P:ceramide biosynthetic process; IMP:BHF-UCL.
GO:0006680; P:glucosylceramide catabolic process; IMP:BHF-UCL.
GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
GO:0032715; P:negative regulation of interleukin-6 production; IDA:BHF-UCL.
GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032463; P:negative regulation of protein homooligomerization; IDA:ParkinsonsUK-UCL.
GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
GO:1904457; P:positive regulation of neuronal action potential; IMP:ParkinsonsUK-UCL.
GO:0043243; P:positive regulation of protein complex disassembly; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IMP:BHF-UCL.
GO:1903061; P:positive regulation of protein lipidation; IGI:ParkinsonsUK-UCL.
GO:0051247; P:positive regulation of protein metabolic process; IGI:ParkinsonsUK-UCL.
GO:1903052; P:positive regulation of proteolysis involved in cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0032268; P:regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0033561; P:regulation of water loss via skin; IEA:Ensembl.
GO:0043627; P:response to estrogen; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0009268; P:response to pH; IEA:Ensembl.
GO:0033574; P:response to testosterone; IEA:Ensembl.
GO:0097066; P:response to thyroid hormone; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0046512; P:sphingosine biosynthetic process; IMP:BHF-UCL.
GO:0023021; P:termination of signal transduction; IMP:BHF-UCL.

HTRA2_HUMAN Serine protease HTRA2, mitochondrial
GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB.
GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB.
GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0044257; P:cellular protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB.
GO:0034605; P:cellular response to heat; IDA:UniProtKB.
GO:0035458; P:cellular response to interferon-beta; IDA:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071300; P:cellular response to retinoic acid; IDA:ParkinsonsUK-UCL.
GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0016540; P:protein autoprocessing; TAS:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.

IF4G1_HUMAN Eukaryotic translation initiation factor 4
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:AgBase.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IMP:ParkinsonsUK-UCL.
GO:0005844; C:polysome; IMP:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:AgBase.
GO:0003729; F:mRNA binding; IDA:ParkinsonsUK-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0032947; F:protein complex scaffold; TAS:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; TAS:ParkinsonsUK-UCL.
GO:0008135; F:translation factor activity, RNA binding; IMP:ParkinsonsUK-UCL.
GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
GO:0031369; F:translation initiation factor binding; TAS:ParkinsonsUK-UCL.
GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO:0002191; P:cap-dependent translational initiation; TAS:ParkinsonsUK-UCL.
GO:0034645; P:cellular macromolecule biosynthetic process; IGI:ParkinsonsUK-UCL.
GO:0032502; P:developmental process; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
GO:0030307; P:positive regulation of cell growth; IMP:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:ParkinsonsUK-UCL.
GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:ParkinsonsUK-UCL.
GO:2000507; P:positive regulation of energy homeostasis; IMP:ParkinsonsUK-UCL.
GO:1905537; P:positive regulation of eukaryotic translation initiation factor 4F complex assembly; IMP:ParkinsonsUK-UCL.
GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:ParkinsonsUK-UCL.
GO:1905618; P:positive regulation of miRNA mediated inhibition of translation; IDA:ParkinsonsUK-UCL.
GO:1905612; P:positive regulation of mRNA cap binding; IDA:ParkinsonsUK-UCL.
GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0080135; P:regulation of cellular response to stress; TAS:ParkinsonsUK-UCL.
GO:0060964; P:regulation of gene silencing by miRNA; TAS:ParkinsonsUK-UCL.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
GO:0006412; P:translation; IMP:ParkinsonsUK-UCL.
GO:0006413; P:translational initiation; NAS:ParkinsonsUK-UCL.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

KLK6_HUMAN Kallikrein-6
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0045171; C:intercellular bridge; IDA:HPA.
GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0042982; P:amyloid precursor protein metabolic process; NAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.
GO:0030574; P:collagen catabolic process; NAS:UniProtKB.
GO:0042445; P:hormone metabolic process; NAS:UniProtKB.
GO:0042552; P:myelination; NAS:UniProtKB.
GO:0070997; P:neuron death; IMP:UniProtKB.
GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
GO:0016540; P:protein autoprocessing; NAS:UniProtKB.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0045595; P:regulation of cell differentiation; NAS:UniProtKB.
GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0042246; P:tissue regeneration; NAS:UniProtKB.

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030159; F:receptor signaling complex scaffold activity; IC:ParkinsonsUK-UCL.
GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.
GO:0000149; F:SNARE binding; IPI:ParkinsonsUK-UCL.
GO:0017075; F:syntaxin-1 binding; IPI:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IDA:BHF-UCL.
GO:0000187; P:activation of MAPK activity; IMP:ParkinsonsUK-UCL.
GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0019722; P:calcium-mediated signaling; IMP:ParkinsonsUK-UCL.
GO:0060070; P:canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0034613; P:cellular protein localization; ISS:ParkinsonsUK-UCL.
GO:1903351; P:cellular response to dopamine; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0009267; P:cellular response to starvation; IMP:ParkinsonsUK-UCL.
GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
GO:0006897; P:endocytosis; IMP:ParkinsonsUK-UCL.
GO:0060079; P:excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0035640; P:exploration behavior; IMP:BHF-UCL.
GO:0007030; P:Golgi organization; IMP:ParkinsonsUK-UCL.
GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.
GO:0035556; P:intracellular signal transduction; ISS:ParkinsonsUK-UCL.
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO:0007040; P:lysosome organization; IMP:ParkinsonsUK-UCL.
GO:0000165; P:MAPK cascade; IDA:UniProtKB.
GO:0051646; P:mitochondrion localization; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0034260; P:negative regulation of GTPase activity; IDA:MGI.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:ParkinsonsUK-UCL.
GO:0010955; P:negative regulation of protein processing; IDA:ParkinsonsUK-UCL.
GO:1903217; P:negative regulation of protein processing involved in protein targeting to mitochondrion; IC:ParkinsonsUK-UCL.
GO:1903215; P:negative regulation of protein targeting to mitochondrion; IDA:ParkinsonsUK-UCL.
GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.
GO:0070997; P:neuron death; IMP:BHF-UCL.
GO:0048812; P:neuron projection morphogenesis; IMP:UniProtKB.
GO:0021772; P:olfactory bulb development; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:0016310; P:phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IC:ParkinsonsUK-UCL.
GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:1902499; P:positive regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0072593; P:reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:ParkinsonsUK-UCL.
GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IMP:ParkinsonsUK-UCL.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL.
GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.
GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.
GO:0035751; P:regulation of lysosomal lumen pH; IMP:ParkinsonsUK-UCL.
GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.
GO:0051900; P:regulation of mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0090140; P:regulation of mitochondrial fission; TAS:ParkinsonsUK-UCL.
GO:1902692; P:regulation of neuroblast proliferation; IMP:ParkinsonsUK-UCL.
GO:1901214; P:regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO:0014041; P:regulation of neuron maturation; IMP:ParkinsonsUK-UCL.
GO:0010738; P:regulation of protein kinase A signaling; ISS:ParkinsonsUK-UCL.
GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IGI:ParkinsonsUK-UCL.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:ParkinsonsUK-UCL.
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:ParkinsonsUK-UCL.
GO:1904887; P:Wnt signalosome assembly; IPI:ParkinsonsUK-UCL.

PACRG_HUMAN Parkin coregulated gene protein
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IDA:ParkinsonsUK-UCL.
GO:0043014; F:alpha-tubulin binding; IDA:ParkinsonsUK-UCL.
GO:0048487; F:beta-tubulin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IDA:ParkinsonsUK-UCL.
GO:0051879; F:Hsp90 protein binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IMP:ParkinsonsUK-UCL.
GO:0007286; P:spermatid development; IEA:Ensembl.

PERQ2_HUMAN PERQ amino acid-rich with GYF
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; IEA:Ensembl.
GO:0007631; P:feeding behavior; IEA:Ensembl.
GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:Ensembl.
GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO:0050881; P:musculoskeletal movement; IEA:Ensembl.
GO:0017148; P:negative regulation of translation; IMP:MGI.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A
GO:0005813; C:centrosome; TAS:UniProtKB.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000226; P:microtubule cytoskeleton organization; TAS:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central.

RNF11_HUMAN RING finger protein 11
GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase.
GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.

SNCAP_HUMAN Synphilin-1
GO:0005737; C:cytoplasm; IDA:MGI.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043025; C:neuronal cell body; NAS:UniProtKB.
GO:0042734; C:presynaptic membrane; NAS:UniProtKB.
GO:0008021; C:synaptic vesicle; TAS:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008219; P:cell death; IDA:CACAO.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0042417; P:dopamine metabolic process; IDA:MGI.
GO:0090083; P:regulation of inclusion body assembly; IDA:BHF-UCL.
GO:0046928; P:regulation of neurotransmitter secretion; IDA:MGI.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYNJ1_HUMAN Synaptojanin-1
GO:0030132; C:clathrin coat of coated pit; ISS:BHF-UCL.
GO:0005829; C:cytosol; ISS:ParkinsonsUK-UCL.
GO:0030117; C:membrane coat; ISS:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IDA:ParkinsonsUK-UCL.
GO:0097060; C:synaptic membrane; ISS:BHF-UCL.
GO:0043195; C:terminal bouton; ISS:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; ISS:ParkinsonsUK-UCL.
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0034596; F:phosphatidylinositol phosphate 4-phosphatase activity; TAS:Reactome.
GO:0034595; F:phosphatidylinositol phosphate 5-phosphatase activity; ISS:ParkinsonsUK-UCL.
GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; TAS:Reactome.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; TAS:Reactome.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:ParkinsonsUK-UCL.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0046855; P:inositol phosphate dephosphorylation; ISS:ParkinsonsUK-UCL.
GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
GO:0007612; P:learning; IMP:ParkinsonsUK-UCL.
GO:0006836; P:neurotransmitter transport; ISS:ParkinsonsUK-UCL.
GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:ParkinsonsUK-UCL.
GO:0046488; P:phosphatidylinositol metabolic process; ISS:ParkinsonsUK-UCL.
GO:1904980; P:positive regulation of endosome organization; IMP:ParkinsonsUK-UCL.
GO:0048488; P:synaptic vesicle endocytosis; IGI:ParkinsonsUK-UCL.
GO:0016082; P:synaptic vesicle priming; ISS:ParkinsonsUK-UCL.
GO:0048489; P:synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0016191; P:synaptic vesicle uncoating; ISS:ParkinsonsUK-UCL.

SYT11_HUMAN Synaptotagmin-11
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0043197; C:dendritic spine; ISS:ParkinsonsUK-UCL.
GO:0032009; C:early phagosome; ISS:ParkinsonsUK-UCL.
GO:0060076; C:excitatory synapse; ISS:ParkinsonsUK-UCL.
GO:0060077; C:inhibitory synapse; ISS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO:0005764; C:lysosome; IEA:Ensembl.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0001891; C:phagocytic cup; IEA:Ensembl.
GO:0045335; C:phagocytic vesicle; ISS:ParkinsonsUK-UCL.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0014069; C:postsynaptic density; ISS:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; ISS:ParkinsonsUK-UCL.
GO:0048787; C:presynaptic active zone membrane; ISS:ParkinsonsUK-UCL.
GO:0055037; C:recycling endosome; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; ISS:ParkinsonsUK-UCL.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0030276; F:clathrin binding; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; ISS:ParkinsonsUK-UCL.
GO:0019905; F:syntaxin binding; IBA:GO_Central.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990927; P:calcium ion regulated lysosome exocytosis; ISS:ParkinsonsUK-UCL.
GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
GO:1900165; P:negative regulation of interleukin-6 secretion; ISS:ParkinsonsUK-UCL.
GO:1905154; P:negative regulation of membrane invagination; IEA:Ensembl.
GO:0046929; P:negative regulation of neurotransmitter secretion; TAS:ParkinsonsUK-UCL.
GO:0050765; P:negative regulation of phagocytosis; IEA:Ensembl.
GO:1900243; P:negative regulation of synaptic vesicle endocytosis; IEA:Ensembl.
GO:1904468; P:negative regulation of tumor necrosis factor secretion; ISS:ParkinsonsUK-UCL.
GO:0001778; P:plasma membrane repair; ISS:ParkinsonsUK-UCL.
GO:1905171; P:positive regulation of protein localization to phagocytic vesicle; ISS:ParkinsonsUK-UCL.
GO:0051289; P:protein homotetramerization; ISS:ParkinsonsUK-UCL.
GO:1900424; P:regulation of defense response to bacterium; IEA:Ensembl.
GO:1905162; P:regulation of phagosome maturation; IC:ParkinsonsUK-UCL.
GO:0006906; P:vesicle fusion; IBA:GO_Central.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TERA_HUMAN Transitional endoplasmic reticulum ATPase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0036513; C:Derlin-1 retrotranslocation complex; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005811; C:lipid particle; IDA:MGI.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0000502; C:proteasome complex; IDA:BHF-UCL.
GO:0035861; C:site of double-strand break; IDA:UniProtKB.
GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; ISS:ParkinsonsUK-UCL.
GO:1990730; C:VCP-NSFL1C complex; ISS:ParkinsonsUK-UCL.
GO:0043531; F:ADP binding; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; IMP:UniProtKB.
GO:1904288; F:BAT3 complex binding; IPI:ParkinsonsUK-UCL.
GO:0035800; F:deubiquitinase activator activity; IDA:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.
GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0044389; F:ubiquitin-like protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO:0070842; P:aggresome assembly; IEA:Ensembl.
GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO:0097352; P:autophagosome maturation; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006302; P:double-strand break repair; IDA:UniProtKB.
GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0036503; P:ERAD pathway; IMP:UniProtKB.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0045184; P:establishment of protein localization; TAS:UniProtKB.
GO:0072389; P:flavin adenine dinucleotide catabolic process; IMP:ParkinsonsUK-UCL.
GO:0006734; P:NADH metabolic process; IMP:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903007; P:positive regulation of Lys63-specific deubiquitinase activity; IDA:ParkinsonsUK-UCL.
GO:0010918; P:positive regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:1903862; P:positive regulation of oxidative phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903006; P:positive regulation of protein K63-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0034214; P:protein hexamerization; IEA:Ensembl.
GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO:0018279; P:protein N-linked glycosylation via asparagine; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
GO:1903715; P:regulation of aerobic respiration; IMP:ParkinsonsUK-UCL.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IDA:UniProtKB.
GO:0019985; P:translesion synthesis; IMP:UniProtKB.
GO:0019079; P:viral genome replication; IMP:CACAO.

TM230_HUMAN Transmembrane protein 230
GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005770; C:late endosome; IDA:UniProtKB.
GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0036465; P:synaptic vesicle recycling; IMP:UniProtKB.

TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0035544; P:negative regulation of SNARE complex assembly; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
GO:0005737; C:cytoplasm; TAS:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0006895; P:Golgi to endosome transport; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1905090; P:negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.

VPS35_HUMAN Vacuolar protein sorting-associated protein 35
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:ParkinsonsUK-UCL.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005770; C:late endosome; IBA:GO_Central.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0099073; C:mitochondrion-derived vesicle; IDA:ParkinsonsUK-UCL.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0030904; C:retromer complex; IDA:ParkinsonsUK-UCL.
GO:0030906; C:retromer, cargo-selective complex; IDA:ParkinsonsUK-UCL.
GO:0097422; C:tubular endosome; IDA:UniProtKB.
GO:0031748; F:D1 dopamine receptor binding; IPI:ParkinsonsUK-UCL.
GO:0008565; F:protein transporter activity; IBA:GO_Central.
GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; IMP:UniProtKB.
GO:0099639; P:neurotransmitter receptor transport, endosome to plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO:1903364; P:positive regulation of cellular protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0061357; P:positive regulation of Wnt protein secretion; IEA:Ensembl.
GO:0032268; P:regulation of cellular protein metabolic process; IDA:ParkinsonsUK-UCL.
GO:1902950; P:regulation of dendritic spine maintenance; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IGI:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:2000331; P:regulation of terminal button organization; IMP:ParkinsonsUK-UCL.
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
GO:1990126; P:retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
GO:0045056; P:transcytosis; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; NAS:ParkinsonsUK-UCL.


LEWY Linkages


#40 LUNG contains 5 proteins

AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome.
GO:0060510; P:Type II pneumocyte differentiation; IEA:Ensembl.

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

PDGFB_HUMAN Platelet-derived growth factor subunit B
GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IBA:GO_Central.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
GO:0005518; F:collagen binding; IDA:MGI.
GO:0008083; F:growth factor activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO:0048407; F:platelet-derived growth factor binding; IPI:BHF-UCL.
GO:0005161; F:platelet-derived growth factor receptor binding; NAS:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0060326; P:cell chemotaxis; IDA:UniProtKB.
GO:0071363; P:cellular response to growth factor stimulus; IDA:BHF-UCL.
GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; TAS:Reactome.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0035655; P:interleukin-18-mediated signaling pathway; IDA:BHF-UCL.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO:0002548; P:monocyte chemotaxis; IDA:BHF-UCL.
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; IDA:BHF-UCL.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1905064; P:negative regulation of vascular smooth muscle cell differentiation; IDA:BHF-UCL.
GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090280; P:positive regulation of calcium ion import; IDA:UniProtKB.
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.
GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
GO:2000573; P:positive regulation of DNA biosynthetic process; IDA:UniProtKB.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO:1900127; P:positive regulation of hyaluronan biosynthetic process; IDA:UniProtKB.
GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; IDA:UniProtKB.
GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IDA:UniProtKB.
GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:UniProtKB.
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:UniProtKB.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IDA:BHF-UCL.
GO:1905176; P:positive regulation of vascular smooth muscle cell dedifferentiation; IDA:BHF-UCL.
GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IDA:BHF-UCL.
GO:0070528; P:protein kinase C signaling; IMP:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.

RENR_HUMAN Renin receptor
GO:0009897; C:external side of plasma membrane; IDA:HGNC.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004872; F:receptor activity; IEA:InterPro.
GO:0002003; P:angiotensin maturation; IDA:HGNC.
GO:0048069; P:eye pigmentation; IMP:UniProtKB.
GO:0060323; P:head morphogenesis; IMP:UniProtKB.
GO:0032914; P:positive regulation of transforming growth factor beta1 production; IDA:HGNC.
GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:UniProtKB.
GO:0043408; P:regulation of MAPK cascade; IDA:HGNC.
GO:0021903; P:rostrocaudal neural tube patterning; IMP:UniProtKB.

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.


LUNG Linkages


#41 MAGNESIUM contains 4 proteins

AT132_HUMAN Probable cation-transporting ATPase 13A2
GO:0005776; C:autophagosome; IDA:ParkinsonsUK-UCL.
GO:1905103; C:integral component of lysosomal membrane; IDA:ParkinsonsUK-UCL.
GO:0016021; C:integral component of membrane; NAS:ParkinsonsUK-UCL.
GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0005770; C:late endosome; IDA:ParkinsonsUK-UCL.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0005771; C:multivesicular body; IDA:ParkinsonsUK-UCL.
GO:0032585; C:multivesicular body membrane; NAS:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:ParkinsonsUK-UCL.
GO:0030133; C:transport vesicle; IDA:ParkinsonsUK-UCL.
GO:0031982; C:vesicle; IDA:ParkinsonsUK-UCL.
GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; NAS:ParkinsonsUK-UCL.
GO:0019829; F:cation-transporting ATPase activity; IBA:GO_Central.
GO:1903135; F:cupric ion binding; ISS:ParkinsonsUK-UCL.
GO:0030145; F:manganese ion binding; ISS:ParkinsonsUK-UCL.
GO:0070300; F:phosphatidic acid binding; IDA:ParkinsonsUK-UCL.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; ISS:ParkinsonsUK-UCL.
GO:1905037; P:autophagosome organization; IDA:ParkinsonsUK-UCL.
GO:0006874; P:cellular calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0030003; P:cellular cation homeostasis; TAS:ParkinsonsUK-UCL.
GO:0006879; P:cellular iron ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071294; P:cellular response to zinc ion; TAS:ParkinsonsUK-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IMP:ParkinsonsUK-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:1905166; P:negative regulation of lysosomal protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; ISS:ParkinsonsUK-UCL.
GO:1990938; P:peptidyl-aspartic acid autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:1905122; P:polyamine import; IDA:ParkinsonsUK-UCL.
GO:1903543; P:positive regulation of exosomal secretion; IDA:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
GO:0046777; P:protein autophosphorylation; TAS:ParkinsonsUK-UCL.
GO:0016243; P:regulation of autophagosome size; IDA:ParkinsonsUK-UCL.
GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL.
GO:0052548; P:regulation of endopeptidase activity; IMP:ParkinsonsUK-UCL.
GO:1905123; P:regulation of glucosylceramidase activity; IEA:Ensembl.
GO:0033157; P:regulation of intracellular protein transport; NAS:ParkinsonsUK-UCL.
GO:1905165; P:regulation of lysosomal protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0016241; P:regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0055069; P:zinc ion homeostasis; IMP:ParkinsonsUK-UCL.

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0044326; C:dendritic spine neck; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0042383; C:sarcolemma; IEA:Ensembl.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IC:UniProtKB.
GO:0045202; C:synapse; ISS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:UniProtKB.
GO:0086037; F:sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA:Ensembl.
GO:1990239; F:steroid hormone binding; NAS:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0015991; P:ATP hydrolysis coupled proton transport; IBA:GO_Central.
GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL.
GO:0071383; P:cellular response to steroid hormone stimulus; NAS:BHF-UCL.
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0010107; P:potassium ion import; IDA:BHF-UCL.
GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:1903416; P:response to glycoside; NAS:BHF-UCL.
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL.
GO:0008542; P:visual learning; IEA:Ensembl.

PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
GO:0005829; C:cytosol; TAS:Reactome.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:Reactome.
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway.
GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB.
GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO:0007165; P:signal transduction; IEA:InterPro.

TRPM7_HUMAN Transient receptor potential cation channel
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0001726; C:ruffle; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0005262; F:calcium channel activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0031032; P:actomyosin structure organization; IEA:Ensembl.
GO:0070588; P:calcium ion transmembrane transport; TAS:Reactome.
GO:0016340; P:calcium-dependent cell-matrix adhesion; IEA:Ensembl.
GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0051262; P:protein tetramerization; IEA:InterPro.


MAGNESIUM Linkages


#42 MANGANESE contains 3 proteins

PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive
GO:0005829; C:cytosol; TAS:Reactome.
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:Reactome.
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway.
GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB.
GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO:0007165; P:signal transduction; IEA:InterPro.

S39AE_HUMAN Zinc transporter ZIP14
GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0016021; C:integral component of membrane; IDA:BHF-UCL.
GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:Ensembl.
GO:0005385; F:zinc ion transmembrane transporter activity; IDA:BHF-UCL.
GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
GO:0071578; P:zinc II ion transmembrane import; IDA:BHF-UCL.
GO:0071577; P:zinc II ion transmembrane transport; IMP:UniProtKB.

ZNT10_HUMAN Zinc transporter 10
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO:0006828; P:manganese ion transport; IMP:UniProtKB.
GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO:0010043; P:response to zinc ion; IBA:GO_Central.


MANGANESE Linkages


#43 MELANOMA contains 1 protein

TAF1_HUMAN Transcription initiation factor TFIID subunit
GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0005667; C:transcription factor complex; IPI:ParkinsonsUK-UCL.
GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
GO:0016301; F:kinase activity; IDA:ParkinsonsUK-UCL.
GO:0070577; F:lysine-acetylated histone binding; IDA:BHF-UCL.
GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IPI:ParkinsonsUK-UCL.
GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IBA:GO_Central.
GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
GO:0017025; F:TBP-class protein binding; IPI:BHF-UCL.
GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:ParkinsonsUK-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071318; P:cellular response to ATP; IDA:ParkinsonsUK-UCL.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:ParkinsonsUK-UCL.
GO:0034644; P:cellular response to UV; IDA:ParkinsonsUK-UCL.
GO:0006352; P:DNA-templated transcription, initiation; ISS:BHF-UCL.
GO:0030901; P:midbrain development; IGI:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:1905524; P:negative regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IDA:ParkinsonsUK-UCL.
GO:0008284; P:positive regulation of cell proliferation; IDA:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IC:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; IDA:ParkinsonsUK-UCL.
GO:0050821; P:protein stabilization; IDA:ParkinsonsUK-UCL.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1902806; P:regulation of cell cycle G1/S phase transition; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IDA:ParkinsonsUK-UCL.
GO:0060260; P:regulation of transcription initiation from RNA polymerase II promoter; NAS:ParkinsonsUK-UCL.
GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; ISS:BHF-UCL.
GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
GO:0036369; P:transcription factor catabolic process; IDA:ParkinsonsUK-UCL.
GO:0006366; P:transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
GO:0016032; P:viral process; IEA:UniProtKB-KW.


MELANOMA Linkages


#44 MEMORY contains 3 proteins

PRIO_HUMAN Major prion protein
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; TAS:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0015631; F:tubulin binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; NAS:UniProtKB.
GO:0071280; P:cellular response to copper ion; IDA:MGI.
GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO:0007611; P:learning or memory; IEA:Ensembl.
GO:0008152; P:metabolic process; TAS:ProtInc.
GO:0046007; P:negative regulation of activated T cell proliferation; ISS:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:BHF-UCL.
GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
GO:0032700; P:negative regulation of interleukin-17 production; ISS:BHF-UCL.
GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:BHF-UCL.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:BHF-UCL.
GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
GO:0032880; P:regulation of protein localization; IEA:Ensembl.
GO:0046686; P:response to cadmium ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; ISS:UniProtKB.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


MEMORY Linkages


#45 MITOCHOND contains 37 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0007005; P:mitochondrion organization; IBA:GO_Central.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:1900037; P:regulation of cellular response to hypoxia; IDA:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

COQ2_HUMAN 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189}
GO:0031305; C:integral component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IMP:UniProtKB.
GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-HAMAP.
GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

DDIT4_HUMAN DNA damage-inducible transcript 4 protein
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005622; C:intracellular; IDA:LIFEdb.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0008283; P:cell proliferation; ISS:UniProtKB.
GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISS:UniProtKB.
GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl.
GO:1902532; P:negative regulation of intracellular signal transduction; ISS:UniProtKB.
GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISS:UniProtKB.
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.
GO:0032007; P:negative regulation of TOR signaling; IMP:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
GO:1901216; P:positive regulation of neuron death; ISS:UniProtKB.
GO:0043241; P:protein complex disassembly; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IDA:UniProtKB.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

FBX7_HUMAN F-box only protein 7
GO:0097414; C:classical Lewy body; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0097409; C:glial cytoplasmic inclusion; IDA:ParkinsonsUK-UCL.
GO:1990037; C:Lewy body core; IDA:ParkinsonsUK-UCL.
GO:1990038; C:Lewy body corona; IDA:ParkinsonsUK-UCL.
GO:0097462; C:Lewy neurite; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0043234; C:protein complex; IDA:LIFEdb.
GO:0019005; C:SCF ubiquitin ligase complex; TAS:ParkinsonsUK-UCL.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0004842; F:ubiquitin-protein transferase activity; TAS:ProtInc.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO:0045620; P:negative regulation of lymphocyte differentiation; IEA:Ensembl.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; IDA:ParkinsonsUK-UCL.
GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0040012; P:regulation of locomotion; IDA:ParkinsonsUK-UCL.
GO:0010975; P:regulation of neuron projection development; IMP:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IDA:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

HTRA2_HUMAN Serine protease HTRA2, mitochondrial
GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB.
GO:0008236; F:serine-type peptidase activity; IDA:UniProtKB.
GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0044257; P:cellular protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB.
GO:0034605; P:cellular response to heat; IDA:UniProtKB.
GO:0035458; P:cellular response to interferon-beta; IDA:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0071300; P:cellular response to retinoic acid; IDA:ParkinsonsUK-UCL.
GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
GO:1901215; P:negative regulation of neuron death; TAS:ParkinsonsUK-UCL.
GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0019742; P:pentacyclic triterpenoid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0016540; P:protein autoprocessing; TAS:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO:0009635; P:response to herbicide; IEA:Ensembl.

KLK6_HUMAN Kallikrein-6
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0045171; C:intercellular bridge; IDA:HPA.
GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0042982; P:amyloid precursor protein metabolic process; NAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.
GO:0030574; P:collagen catabolic process; NAS:UniProtKB.
GO:0042445; P:hormone metabolic process; NAS:UniProtKB.
GO:0042552; P:myelination; NAS:UniProtKB.
GO:0070997; P:neuron death; IMP:UniProtKB.
GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
GO:0016540; P:protein autoprocessing; NAS:UniProtKB.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0045595; P:regulation of cell differentiation; NAS:UniProtKB.
GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO:0009611; P:response to wounding; NAS:UniProtKB.
GO:0042246; P:tissue regeneration; NAS:UniProtKB.

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0030159; F:receptor signaling complex scaffold activity; IC:ParkinsonsUK-UCL.
GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.
GO:0000149; F:SNARE binding; IPI:ParkinsonsUK-UCL.
GO:0017075; F:syntaxin-1 binding; IPI:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IDA:BHF-UCL.
GO:0000187; P:activation of MAPK activity; IMP:ParkinsonsUK-UCL.
GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0019722; P:calcium-mediated signaling; IMP:ParkinsonsUK-UCL.
GO:0060070; P:canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0034613; P:cellular protein localization; ISS:ParkinsonsUK-UCL.
GO:1903351; P:cellular response to dopamine; IMP:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0009267; P:cellular response to starvation; IMP:ParkinsonsUK-UCL.
GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
GO:0006897; P:endocytosis; IMP:ParkinsonsUK-UCL.
GO:0060079; P:excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0035640; P:exploration behavior; IMP:BHF-UCL.
GO:0007030; P:Golgi organization; IMP:ParkinsonsUK-UCL.
GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.
GO:0035556; P:intracellular signal transduction; ISS:ParkinsonsUK-UCL.
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO:0007040; P:lysosome organization; IMP:ParkinsonsUK-UCL.
GO:0000165; P:MAPK cascade; IDA:UniProtKB.
GO:0051646; P:mitochondrion localization; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0090394; P:negative regulation of excitatory postsynaptic potential; ISS:ParkinsonsUK-UCL.
GO:0034260; P:negative regulation of GTPase activity; IDA:MGI.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1902823; P:negative regulation of late endosome to lysosome transport; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; ISS:ParkinsonsUK-UCL.
GO:0010955; P:negative regulation of protein processing; IDA:ParkinsonsUK-UCL.
GO:1903217; P:negative regulation of protein processing involved in protein targeting to mitochondrion; IC:ParkinsonsUK-UCL.
GO:1903215; P:negative regulation of protein targeting to mitochondrion; IDA:ParkinsonsUK-UCL.
GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.
GO:0070997; P:neuron death; IMP:BHF-UCL.
GO:0048812; P:neuron projection morphogenesis; IMP:UniProtKB.
GO:0021772; P:olfactory bulb development; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
GO:0016310; P:phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IC:ParkinsonsUK-UCL.
GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:1902499; P:positive regulation of protein autoubiquitination; IDA:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0072593; P:reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO:2000172; P:regulation of branching morphogenesis of a nerve; IMP:ParkinsonsUK-UCL.
GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IMP:ParkinsonsUK-UCL.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL.
GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.
GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.
GO:0035751; P:regulation of lysosomal lumen pH; IMP:ParkinsonsUK-UCL.
GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.
GO:0051900; P:regulation of mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0090140; P:regulation of mitochondrial fission; TAS:ParkinsonsUK-UCL.
GO:1902692; P:regulation of neuroblast proliferation; IMP:ParkinsonsUK-UCL.
GO:1901214; P:regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO:0014041; P:regulation of neuron maturation; IMP:ParkinsonsUK-UCL.
GO:0010738; P:regulation of protein kinase A signaling; ISS:ParkinsonsUK-UCL.
GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IGI:ParkinsonsUK-UCL.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:ParkinsonsUK-UCL.
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; ISS:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:ParkinsonsUK-UCL.
GO:1904887; P:Wnt signalosome assembly; IPI:ParkinsonsUK-UCL.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.

PARK7_HUMAN Protein deglycase DJ-1 {ECO:0000303|PubMed:25416785}
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL.
GO:0098793; C:presynapse; IEA:GOC.
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL.
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL.
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IEA:Ensembl.
GO:0019172; F:glyoxalase III activity; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL.
GO:0045340; F:mercury ion binding; IDA:UniProtKB.
GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL.
GO:0008233; F:peptidase activity; IDA:UniProtKB.
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO:0036524; F:protein deglycase activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL.
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL.
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL.
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL.
GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL.
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0010273; P:detoxification of copper ion; IMP:UniProtKB.
GO:0050787; P:detoxification of mercury ion; IMP:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO:0036531; P:glutathione deglycation; IDA:ParkinsonsUK-UCL.
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:1903189; P:glyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0019249; P:lactate biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:Ensembl.
GO:0009438; P:methylglyoxal metabolic process; IDA:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL.
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL.
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL.
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL.
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL.
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL.
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL.
GO:0036527; P:peptidyl-arginine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036526; P:peptidyl-cysteine deglycation; IDA:ParkinsonsUK-UCL.
GO:0036528; P:peptidyl-lysine deglycation; IDA:ParkinsonsUK-UCL.
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL.
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; TAS:ParkinsonsUK-UCL.
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL.
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL.
GO:1903599; P:positive regulation of mitophagy; NAS:ParkinsonsUK-UCL.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL.
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL.
GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:ParkinsonsUK-UCL.
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:ParkinsonsUK-UCL.
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL.
GO:0036529; P:protein deglycation, glyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0036530; P:protein deglycation, methylglyoxal removal; IDA:ParkinsonsUK-UCL.
GO:0006517; P:protein deglycosylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0007265; P:Ras protein signal transduction; TAS:ParkinsonsUK-UCL.
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB.
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial
GO:0097449; C:astrocyte projection; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:ParkinsonsUK-UCL.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL.
GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005856; C:cytoskeleton; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0031307; C:integral component of mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; IDA:ParkinsonsUK-UCL.
GO:0005758; C:mitochondrial intermembrane space; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0055131; F:C3HC4-type RING finger domain binding; IPI:BHF-UCL.
GO:0010857; F:calcium-dependent protein kinase activity; IDA:BHF-UCL.
GO:0016301; F:kinase activity; NAS:ParkinsonsUK-UCL.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016504; F:peptidase activator activity; TAS:ParkinsonsUK-UCL.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IMP:ParkinsonsUK-UCL.
GO:0043422; F:protein kinase B binding; IDA:ParkinsonsUK-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IC:ParkinsonsUK-UCL.
GO:0071456; P:cellular response to hypoxia; IMP:ParkinsonsUK-UCL.
GO:0034599; P:cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; TAS:ParkinsonsUK-UCL.
GO:0072655; P:establishment of protein localization to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0072656; P:maintenance of protein location in mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IMP:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IMP:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:1902902; P:negative regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; ISS:ParkinsonsUK-UCL.
GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903298; P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903751; P:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IDA:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; TAS:ParkinsonsUK-UCL.
GO:0016242; P:negative regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:0090258; P:negative regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:1903147; P:negative regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL.
GO:1903204; P:negative regulation of oxidative stress-induced neuron death; TAS:ParkinsonsUK-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:0036289; P:peptidyl-serine autophosphorylation; IMP:ParkinsonsUK-UCL.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0016310; P:phosphorylation; NAS:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903852; P:positive regulation of cristae formation; IMP:ParkinsonsUK-UCL.
GO:0033603; P:positive regulation of dopamine secretion; IEA:Ensembl.
GO:1904544; P:positive regulation of free ubiquitin chain polymerization; ISS:ParkinsonsUK-UCL.
GO:1901727; P:positive regulation of histone deacetylase activity; IEA:Ensembl.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:BHF-UCL.
GO:0016239; P:positive regulation of macroautophagy; IMP:ParkinsonsUK-UCL.
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; IBA:GO_Central.
GO:0010952; P:positive regulation of peptidase activity; TAS:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0035307; P:positive regulation of protein dephosphorylation; IEA:Ensembl.
GO:0051897; P:positive regulation of protein kinase B signaling; IC:ParkinsonsUK-UCL.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:AgBase.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; ISS:ParkinsonsUK-UCL.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:BHF-UCL.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; TAS:ParkinsonsUK-UCL.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:1900407; P:regulation of cellular response to oxidative stress; IMP:ParkinsonsUK-UCL.
GO:0010310; P:regulation of hydrogen peroxide metabolic process; IEA:Ensembl.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:0010821; P:regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1903146; P:regulation of mitophagy; TAS:ParkinsonsUK-UCL.
GO:0002082; P:regulation of oxidative phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0061136; P:regulation of proteasomal protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0043254; P:regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; IDA:AgBase.
GO:0031396; P:regulation of protein ubiquitination; IDA:BHF-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:ParkinsonsUK-UCL.
GO:1902803; P:regulation of synaptic vesicle transport; TAS:ParkinsonsUK-UCL.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IGI:ParkinsonsUK-UCL.
GO:0006950; P:response to stress; IDA:UniProtKB.
GO:0038203; P:TORC2 signaling; IC:ParkinsonsUK-UCL.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.

PRKN2_HUMAN E3 ubiquitin-protein ligase parkin
GO:0016235; C:aggresome; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0097413; C:Lewy body; TAS:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IPI:ParkinsonsUK-UCL.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0008013; F:beta-catenin binding; IDA:ParkinsonsUK-UCL.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0097602; F:cullin family protein binding; IDA:ParkinsonsUK-UCL.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:1990444; F:F-box domain binding; IPI:ParkinsonsUK-UCL.
GO:0001664; F:G-protein coupled receptor binding; IPI:ParkinsonsUK-UCL.
GO:0031072; F:heat shock protein binding; IPI:ParkinsonsUK-UCL.
GO:0042826; F:histone deacetylase binding; IPI:ParkinsonsUK-UCL.
GO:0030544; F:Hsp70 protein binding; IPI:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019900; F:kinase binding; IPI:UniProtKB.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.
GO:0043274; F:phospholipase binding; IPI:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0017124; F:SH3 domain binding; TAS:ParkinsonsUK-UCL.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IC:ParkinsonsUK-UCL.
GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO:0015631; F:tubulin binding; IPI:ParkinsonsUK-UCL.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:ParkinsonsUK-UCL.
GO:0061630; F:ubiquitin protein ligase activity; IDA:UniProtKB.
GO:1904264; F:ubiquitin protein ligase activity involved in ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; TAS:ParkinsonsUK-UCL.
GO:0008344; P:adult locomotory behavior; ISS:ParkinsonsUK-UCL.
GO:0070842; P:aggresome assembly; IMP:BHF-UCL.
GO:0044257; P:cellular protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:1903351; P:cellular response to dopamine; TAS:ParkinsonsUK-UCL.
GO:0071287; P:cellular response to manganese ion; TAS:ParkinsonsUK-UCL.
GO:0097237; P:cellular response to toxic substance; IMP:ParkinsonsUK-UCL.
GO:0034620; P:cellular response to unfolded protein; TAS:ParkinsonsUK-UCL.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0042417; P:dopamine metabolic process; TAS:ParkinsonsUK-UCL.
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO:0036503; P:ERAD pathway; NAS:ParkinsonsUK-UCL.
GO:0010994; P:free ubiquitin chain polymerization; IMP:ParkinsonsUK-UCL.
GO:0007612; P:learning; IEA:Ensembl.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000266; P:mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; ISS:ParkinsonsUK-UCL.
GO:0099074; P:mitochondrion to lysosome transport; IDA:ParkinsonsUK-UCL.
GO:0000422; P:mitophagy; IDA:UniProtKB.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:0044828; P:negative regulation by host of viral genome replication; IDA:AgBase.
GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0060548; P:negative regulation of cell death; IDA:BHF-UCL.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1903382; P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1903542; P:negative regulation of exosomal secretion; IMP:ParkinsonsUK-UCL.
GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
GO:1905366; P:negative regulation of intralumenal vesicle formation; IMP:ParkinsonsUK-UCL.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IMP:ParkinsonsUK-UCL.
GO:0046329; P:negative regulation of JNK cascade; ISS:ParkinsonsUK-UCL.
GO:0010637; P:negative regulation of mitochondrial fusion; ISS:ParkinsonsUK-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:ParkinsonsUK-UCL.
GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
GO:1903202; P:negative regulation of oxidative stress-induced cell death; NAS:ParkinsonsUK-UCL.
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1902283; P:negative regulation of primary amine oxidase activity; IMP:ParkinsonsUK-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IGI:ParkinsonsUK-UCL.
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
GO:1904049; P:negative regulation of spontaneous neurotransmitter secretion; IMP:ParkinsonsUK-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:ParkinsonsUK-UCL.
GO:0070050; P:neuron cellular homeostasis; ISS:ParkinsonsUK-UCL.
GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO:0061734; P:parkin-mediated mitophagy in response to mitochondrial depolarization; IDA:ParkinsonsUK-UCL.
GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
GO:0043388; P:positive regulation of DNA binding; IDA:ParkinsonsUK-UCL.
GO:0010628; P:positive regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ParkinsonsUK-UCL.
GO:0090141; P:positive regulation of mitochondrial fission; ISS:ParkinsonsUK-UCL.
GO:0010636; P:positive regulation of mitochondrial fusion; IMP:ParkinsonsUK-UCL.
GO:0051582; P:positive regulation of neurotransmitter uptake; IMP:ParkinsonsUK-UCL.
GO:1903378; P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IGI:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; IMP:ParkinsonsUK-UCL.
GO:0045732; P:positive regulation of protein catabolic process; TAS:ParkinsonsUK-UCL.
GO:1902530; P:positive regulation of protein linear polyubiquitination; IGI:ParkinsonsUK-UCL.
GO:1905477; P:positive regulation of protein localization to membrane; IMP:ParkinsonsUK-UCL.
GO:1905281; P:positive regulation of retrograde transport, endosome to Golgi; NAS:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL.
GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IDA:ParkinsonsUK-UCL.
GO:0010498; P:proteasomal protein catabolic process; IMP:BHF-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:ParkinsonsUK-UCL.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:ParkinsonsUK-UCL.
GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
GO:0044314; P:protein K27-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0035519; P:protein K29-linked ubiquitination; TAS:ParkinsonsUK-UCL.
GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.
GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
GO:0060828; P:regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:1900407; P:regulation of cellular response to oxidative stress; IDA:ParkinsonsUK-UCL.
GO:0042053; P:regulation of dopamine metabolic process; IMP:ParkinsonsUK-UCL.
GO:0014059; P:regulation of dopamine secretion; TAS:ParkinsonsUK-UCL.
GO:0010906; P:regulation of glucose metabolic process; TAS:ParkinsonsUK-UCL.
GO:0032368; P:regulation of lipid transport; TAS:ParkinsonsUK-UCL.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IDA:ParkinsonsUK-UCL.
GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL.
GO:1903214; P:regulation of protein targeting to mitochondrion; NAS:ParkinsonsUK-UCL.
GO:0031396; P:regulation of protein ubiquitination; IMP:ParkinsonsUK-UCL.
GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
GO:1902803; P:regulation of synaptic vesicle transport; NAS:ParkinsonsUK-UCL.
GO:0034976; P:response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006979; P:response to oxidative stress; ISS:ParkinsonsUK-UCL.
GO:0001964; P:startle response; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0055069; P:zinc ion homeostasis; ISS:ParkinsonsUK-UCL.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

TERA_HUMAN Transitional endoplasmic reticulum ATPase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0036513; C:Derlin-1 retrotranslocation complex; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005811; C:lipid particle; IDA:MGI.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
GO:0000502; C:proteasome complex; IDA:BHF-UCL.
GO:0035861; C:site of double-strand break; IDA:UniProtKB.
GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; ISS:ParkinsonsUK-UCL.
GO:1990730; C:VCP-NSFL1C complex; ISS:ParkinsonsUK-UCL.
GO:0043531; F:ADP binding; IEA:Ensembl.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; IMP:UniProtKB.
GO:1904288; F:BAT3 complex binding; IPI:ParkinsonsUK-UCL.
GO:0035800; F:deubiquitinase activator activity; IDA:ParkinsonsUK-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.
GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0044389; F:ubiquitin-like protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO:0070842; P:aggresome assembly; IEA:Ensembl.
GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO:0097352; P:autophagosome maturation; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006302; P:double-strand break repair; IDA:UniProtKB.
GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:ParkinsonsUK-UCL.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO:0036503; P:ERAD pathway; IMP:UniProtKB.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0045184; P:establishment of protein localization; TAS:UniProtKB.
GO:0072389; P:flavin adenine dinucleotide catabolic process; IMP:ParkinsonsUK-UCL.
GO:0006734; P:NADH metabolic process; IMP:ParkinsonsUK-UCL.
GO:2001171; P:positive regulation of ATP biosynthetic process; IMP:ParkinsonsUK-UCL.
GO:1903007; P:positive regulation of Lys63-specific deubiquitinase activity; IDA:ParkinsonsUK-UCL.
GO:0010918; P:positive regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL.
GO:1903862; P:positive regulation of oxidative phosphorylation; IMP:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:1903006; P:positive regulation of protein K63-linked deubiquitination; IDA:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0034214; P:protein hexamerization; IEA:Ensembl.
GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO:0018279; P:protein N-linked glycosylation via asparagine; IMP:UniProtKB.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
GO:1903715; P:regulation of aerobic respiration; IMP:ParkinsonsUK-UCL.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IDA:UniProtKB.
GO:0019985; P:translesion synthesis; IMP:UniProtKB.
GO:0019079; P:viral genome replication; IMP:CACAO.

VP13C_HUMAN Vacuolar protein sorting-associated protein 13C
GO:0005737; C:cytoplasm; TAS:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0005741; C:mitochondrial outer membrane; IDA:ParkinsonsUK-UCL.
GO:0006895; P:Golgi to endosome transport; TAS:ParkinsonsUK-UCL.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1905090; P:negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization; IMP:ParkinsonsUK-UCL.
GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.


MITOCHOND Linkages


#46 MT-C1D contains 18 proteins

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.


MT-C1D Linkages


#47 MYOCLONUS contains 2 proteins

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.


MYOCLONUS Linkages


#48 NBIA contains 5 proteins

COASY_HUMAN Dephospho-CoA kinase
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0009108; P:coenzyme biosynthetic process; TAS:Reactome.

CS012_HUMAN Protein C19orf12
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
GO:0006979; P:response to oxidative stress; IMP:UniProtKB.

FRIL_HUMAN Ferritin light chain
GO:0044754; C:autolysosome; IDA:MGI.
GO:0005737; C:cytoplasm; IBA:GO_Central.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0008043; C:intracellular ferritin complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0008199; F:ferric iron binding; IEA:InterPro.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005506; F:iron ion binding; IDA:UniProtKB.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
GO:0055072; P:iron ion homeostasis; TAS:UniProtKB.
GO:0006826; P:iron ion transport; IEA:InterPro.

PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
GO:0016787; F:hydrolase activity; TAS:Reactome.
GO:0004623; F:phospholipase A2 activity; TAS:Reactome.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
GO:0090238; P:positive regulation of arachidonic acid secretion; IEA:Ensembl.
GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO:0045909; P:positive regulation of vasodilation; IEA:Ensembl.
GO:1901339; P:regulation of store-operated calcium channel activity; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0014832; P:urinary bladder smooth muscle contraction; IEA:Ensembl.

WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
GO:0034045; C:pre-autophagosomal structure membrane; IBA:GO_Central.
GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0000422; P:mitophagy; IBA:GO_Central.
GO:0044804; P:nucleophagy; IBA:GO_Central.
GO:0006497; P:protein lipidation; IBA:GO_Central.
GO:0034497; P:protein localization to pre-autophagosomal structure; IBA:GO_Central.


NBIA Linkages


#49 NYSTAGMUS contains 2 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0044326; C:dendritic spine neck; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0042383; C:sarcolemma; IEA:Ensembl.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IC:UniProtKB.
GO:0045202; C:synapse; ISS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:UniProtKB.
GO:0086037; F:sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA:Ensembl.
GO:1990239; F:steroid hormone binding; NAS:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0015991; P:ATP hydrolysis coupled proton transport; IBA:GO_Central.
GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL.
GO:0071383; P:cellular response to steroid hormone stimulus; NAS:BHF-UCL.
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0010107; P:potassium ion import; IDA:BHF-UCL.
GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:1903416; P:response to glycoside; NAS:BHF-UCL.
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL.
GO:0008542; P:visual learning; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


NYSTAGMUS Linkages


#50 OPHTHALMOPLEGIA contains 6 proteins

ADT1_HUMAN ADP/ATP translocase 1
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060546; P:negative regulation of necroptotic process; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0006810; P:transport; TAS:ProtInc.
GO:0016032; P:viral process; IEA:UniProtKB-KW.

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

DPOG1_HUMAN DNA polymerase subunit gamma-1
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005739; C:mitochondrion; TAS:ProtInc.
GO:0043234; C:protein complex; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; IDA:MGI.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0007568; P:aging; IEA:Ensembl.
GO:0006287; P:base-excision repair, gap-filling; IDA:MGI.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
GO:0010332; P:response to gamma radiation; IEA:Ensembl.
GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO:0009416; P:response to light stimulus; IEA:Ensembl.

DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000262; C:mitochondrial chromosome; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003887; F:DNA-directed DNA polymerase activity; TAS:ProtInc.
GO:0004820; F:glycine-tRNA ligase activity; IBA:GO_Central.
GO:0006281; P:DNA repair; NAS:UniProtKB.
GO:0006260; P:DNA replication; NAS:UniProtKB.
GO:0006261; P:DNA-dependent DNA replication; TAS:ProtInc.
GO:0006426; P:glycyl-tRNA aminoacylation; IBA:GO_Central.
GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO:0032042; P:mitochondrial DNA metabolic process; IEA:Ensembl.
GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

PEO1_HUMAN Twinkle protein, mitochondrial
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
GO:0043139; F:5'-3' DNA helicase activity; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0002020; F:protease binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IMP:UniProtKB.
GO:0007005; P:mitochondrion organization; TAS:Reactome.
GO:0034214; P:protein hexamerization; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB.

RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005971; C:ribonucleoside-diphosphate reductase complex; IBA:GO_Central.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IBA:GO_Central.
GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Ensembl.
GO:0009263; P:deoxyribonucleotide biosynthetic process; IBA:GO_Central.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; IEA:Ensembl.
GO:0006264; P:mitochondrial DNA replication; IEA:Ensembl.
GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
GO:0003014; P:renal system process; IEA:Ensembl.
GO:0014075; P:response to amine; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.


OPHTHALMOPLEGIA Linkages


#51 OPTIC contains 21 proteins

AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0044326; C:dendritic spine neck; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0042383; C:sarcolemma; IEA:Ensembl.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IC:UniProtKB.
GO:0045202; C:synapse; ISS:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0051087; F:chaperone binding; IPI:BHF-UCL.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; IMP:UniProtKB.
GO:0086037; F:sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential; IEA:Ensembl.
GO:1990239; F:steroid hormone binding; NAS:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0015991; P:ATP hydrolysis coupled proton transport; IBA:GO_Central.
GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL.
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL.
GO:0071383; P:cellular response to steroid hormone stimulus; NAS:BHF-UCL.
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0010107; P:potassium ion import; IDA:BHF-UCL.
GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:1903416; P:response to glycoside; NAS:BHF-UCL.
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL.
GO:0008542; P:visual learning; IEA:Ensembl.

ATX2_HUMAN Ataxin-2
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005844; C:polysome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
GO:0010603; P:regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO:0006417; P:regulation of translation; NAS:UniProtKB.
GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
GO:0050658; P:RNA transport; NAS:UniProtKB.
GO:0034063; P:stress granule assembly; IMP:UniProtKB.

FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IMP:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

MIMIT_HUMAN Mimitin, mitochondrial
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.

NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:LIFEdb.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0030961; P:peptidyl-arginine hydroxylation; IMP:UniProtKB.

NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I,
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016740; F:transferase activity; IEA:InterPro.
GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
GO:0009058; P:biosynthetic process; IEA:InterPro.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit,
GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0008637; P:apoptotic mitochondrial changes; IDA:UniProtKB.
GO:0046034; P:ATP metabolic process; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.

NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0009055; F:electron carrier activity; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0006979; P:response to oxidative stress; IDA:UniProtKB.

NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
GO:0007420; P:brain development; IMP:UniProtKB.
GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0001932; P:regulation of protein phosphorylation; IMP:MGI.
GO:0051591; P:response to cAMP; IMP:UniProtKB.

NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; NAS:UniProtKB.
GO:0048038; F:quinone binding; IEA:InterPro.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.

NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1,
GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
GO:0010181; F:FMN binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051287; F:NAD binding; IBA:GO_Central.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO:0009642; P:response to light intensity; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.

NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.

NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005739; C:mitochondrion; IBA:GO_Central.
GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; TAS:Reactome.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO:0035094; P:response to nicotine; IEA:Ensembl.

NUBPL_HUMAN Iron-sulfur protein NUBPL
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


OPTIC Linkages


#52 OVARIAN contains 4 proteins

LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0099400; C:caveola neck; IDA:ParkinsonsUK-UCL.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IDA:UniProtKB.
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL.
GO:0030425; C:dendrite; IDA:UniProtKB.
GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO:0005768; C:endosome; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO:0005798; C:Golgi-associated vesicle; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:ParkinsonsUK-UCL.
GO:0016234; C:inclusion body; IMP:ParkinsonsUK-UCL.
GO:0005622; C:intracellular; IMP:ParkinsonsUK-UCL.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005764; C:lysosome; ISS:UniProtKB.
GO:0005902; C:microvillus; IDA:ParkinsonsUK-UCL.
GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
GO:0031966; C:mitochondrial membrane; IDA:ParkinsonsUK-UCL.
GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0097487; C:multivesicular body, internal vesicle; IDA:ParkinsonsUK-UCL.
GO:0043005; C:neuron projection; IDA:ParkinsonsUK-UCL.
GO:0043025; C:neuronal cell body; IDA:BHF-UCL.
GO:0043204; C:perikaryon; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:ParkinsonsUK-UCL.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0043195; C:terminal bouton; TAS:ParkinsonsUK-UCL.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; IDA:ParkinsonsUK-UCL.
GO:0003779; F:actin binding; IPI:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:1904713; F:beta-catenin destruction complex binding; NAS:ParkinsonsUK-UCL.
GO:0030276; F:clathrin binding; IPI:ParkinsonsUK-UCL.
GO:0039706; F:co-receptor binding; TAS:ParkinsonsUK-UCL.
GO:0001948; F:glycoprotein binding; IPI:ParkinsonsUK-UCL.
GO:0005525; F:GTP binding; IDA:UniProtKB.
GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.
GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO:0003924; F:GTPase activity; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.
GO:0008017; F:microtubule binding; TAS:ParkinsonsUK-UCL.
GO:0036479; F:peroxidase inhibitor activity; IDA:ParkinsonsUK-UCL.
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0051018; F:protein kinase A binding; IPI:ParkinsonsUK-UCL.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kin