Disease Motifs
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Set Theory

Set Theory as applied to the proteins associated with Alzhiemer's disease

There are 46 subsets from the Alzhiemer's disease set so far but this may change as some sets maybe be merged together and other new sets may be created. If anyone would like to make any suggestions about: creating another set, deleting a set or merging two or more sets together, please feel free to do so. Some of these sets have been created in a very superficial way and have been grouped due to casual comments made by the person who wrote the datasheet who may have just listed off symptoms on a particular protein's datasheet rather than listing specific, relevant and related details regarding a particular protein.



#1 ADENOCARCINOMA contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
MARK1_HUMAN Serine/threonine-protein kinase MARK1 → A : → G

ADENOCARCINOMA Linkages


#2 AMYOTROPHIC contains 4 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
PAWR_HUMAN PRKC apoptosis WT1 regulator protein → A
PCSK1_HUMAN Big LEN → A
SQSTM_HUMAN Sequestosome-1 → A : → G

AMYOTROPHIC Linkages


#3 APOPTOSIS contains 22 proteins

A4_HUMAN C31 → A : → G
APBB1_HUMAN Amyloid beta A4 precursor protein-binding → A
CASP4_HUMAN Caspase-4 subunit 2 → A
CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1, → A
CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
CSEN_HUMAN Calsenilin → A : → G
DHC24_HUMAN Delta(24)-sterol reductase → A : → G
DNM1L_HUMAN Dynamin-1-like protein → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase → A
GSK3A_HUMAN Glycogen synthase kinase-3 alpha → A
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
HMGB1_HUMAN High mobility group protein B1 → A
HUNIN_HUMAN Humanin {ECO:0000305} → A
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
OLR1_HUMAN Oxidized low-density lipoprotein receptor 1, → A : → G
PAWR_HUMAN PRKC apoptosis WT1 regulator protein → A
PGH2_HUMAN Prostaglandin G/H synthase 2 → A
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
SDIM1_HUMAN Stress-responsive DNAJB4-interacting membrane protein 1 → A
SQSTM_HUMAN Sequestosome-1 → A : → G
TNR21_HUMAN Tumor necrosis factor receptor superfamily → A

APOPTOSIS Linkages


#4 ATAXIA contains 1 protein

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

ATAXIA Linkages


#5 BEHAV contains 6 proteins

DOCK3_HUMAN Dedicator of cytokinesis protein 3 → A
GPR3_HUMAN G-protein coupled receptor 3 → A
HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2 → A : → G
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
SQSTM_HUMAN Sequestosome-1 → A : → G
TAU_HUMAN Microtubule-associated protein tau → A : → G

BEHAV Linkages


#6 BREAST contains 12 proteins

BACE2_HUMAN Beta-secretase 2 → A
CATD_HUMAN Cathepsin D heavy chain → A : → G
CSEN_HUMAN Calsenilin → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
FLNB_HUMAN Filamin-B → A : → G
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
GPC1_HUMAN Secreted glypican-1 → A : → G
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
KC1D_HUMAN Casein kinase I isoform delta → A : → G
KLK8_HUMAN Kallikrein-8 → A
RN146_HUMAN E3 ubiquitin-protein ligase RNF146 → A
SORL_HUMAN Sortilin-related receptor → A : → G

BREAST Linkages


#7 CALCIUM contains 12 proteins

CAHM1_HUMAN Calcium homeostasis modulator protein 1 → A
CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
COL12_HUMAN Collectin-12 → A
CSEN_HUMAN Calsenilin → A : → G
CSTN1_HUMAN CTF1-alpha → A
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 → A : → G
NEUG_HUMAN NEUG(55-78) → A
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
REG1A_HUMAN Lithostathine-1-alpha → A
UBXN4_HUMAN UBX domain-containing protein 4 → A
VISL1_HUMAN Visinin-like protein 1 → A

CALCIUM Linkages


#8 CANCER contains 25 proteins

BHLH9_HUMAN Protein BHLHb9 → A
CATD_HUMAN Cathepsin D heavy chain → A : → G
CSEN_HUMAN Calsenilin → A : → G
DKK1_HUMAN Dickkopf-related protein 1 → A
DKK2_HUMAN Dickkopf-related protein 2 → A
DKK3_HUMAN Dickkopf-related protein 3 → A
DKK4_HUMAN Dickkopf-related protein 4 short form → A
DPYL2_HUMAN Dihydropyrimidinase-related protein 2 → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
FLNB_HUMAN Filamin-B → A : → G
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
GPC1_HUMAN Secreted glypican-1 → A : → G
GSAP_HUMAN Gamma-secretase-activating protein 16 kDa C-terminal → A
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
HMGB1_HUMAN High mobility group protein B1 → A
KC1D_HUMAN Casein kinase I isoform delta → A : → G
KLK8_HUMAN Kallikrein-8 → A
NDRG2_HUMAN Protein NDRG2 → A
PAWR_HUMAN PRKC apoptosis WT1 regulator protein → A
PGH1_HUMAN Prostaglandin G/H synthase 1 → A
PGH2_HUMAN Prostaglandin G/H synthase 2 → A
RN146_HUMAN E3 ubiquitin-protein ligase RNF146 → A
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SORL_HUMAN Sortilin-related receptor → A : → G
TEFF2_HUMAN Tomoregulin-2 → A

CANCER Linkages


#9 CARCINOMA contains 10 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
HMGB1_HUMAN High mobility group protein B1 → A
KC1D_HUMAN Casein kinase I isoform delta → A : → G
KLK8_HUMAN Kallikrein-8 → A
MARK1_HUMAN Serine/threonine-protein kinase MARK1 → A : → G
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
RBG1L_HUMAN Rab GTPase-activating protein 1-like → A
SQSTM_HUMAN Sequestosome-1 → A : → G
TEFF2_HUMAN Tomoregulin-2 → A

CARCINOMA Linkages


#10 CARDIOMYOPATHY contains 3 proteins

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
PSN2_HUMAN Presenilin-2 CTF subunit → A : → G

CARDIOMYOPATHY Linkages


#11 COLORECTAL contains 5 proteins

DPYL2_HUMAN Dihydropyrimidinase-related protein 2 → A : → G
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SORL_HUMAN Sortilin-related receptor → A : → G
TEFF2_HUMAN Tomoregulin-2 → A

COLORECTAL Linkages


#12 COPPER contains 3 proteins

A4_HUMAN C31 → A : → G
MT3_HUMAN Metallothionein-3 → A
SYUA_HUMAN Alpha-synuclein → A : → G

COPPER Linkages


#13 DIABETES contains 6 proteins

GSK3A_HUMAN Glycogen synthase kinase-3 alpha → A
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
HMGB1_HUMAN High mobility group protein B1 → A
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
OLR1_HUMAN Oxidized low-density lipoprotein receptor 1, → A : → G

DIABETES Linkages


#14 EXTRAPYRAMIDAL contains 1 protein

TAU_HUMAN Microtubule-associated protein tau → A : → G

EXTRAPYRAMIDAL Linkages


#15 FINGER contains 12 proteins

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein → A : → G
BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF → A
FLNB_HUMAN Filamin-B → A : → G
MAZ_HUMAN Myc-associated zinc finger protein → A
RBG1L_HUMAN Rab GTPase-activating protein 1-like → A
RN146_HUMAN E3 ubiquitin-protein ligase RNF146 → A
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SQSTM_HUMAN Sequestosome-1 → A : → G
SR1IP_HUMAN Protein SREK1IP1 → A
TSH1_HUMAN Teashirt homolog 1 → A
TSH2_HUMAN Teashirt homolog 2 → A
TSH3_HUMAN Teashirt homolog 3 → A

FINGER Linkages


#16 GASTR contains 7 proteins

HMGB1_HUMAN High mobility group protein B1 → A
HRH2_HUMAN Histamine H2 receptor → A : → G
HUNIN_HUMAN Humanin {ECO:0000305} → A
MARK1_HUMAN Serine/threonine-protein kinase MARK1 → A : → G
PGH1_HUMAN Prostaglandin G/H synthase 1 → A
PGH2_HUMAN Prostaglandin G/H synthase 2 → A
PSA_HUMAN Puromycin-sensitive aminopeptidase → A

GASTR Linkages


#17 GLUCOSE contains 8 proteins

AATC_HUMAN Aspartate aminotransferase, cytoplasmic → A
ATS4_HUMAN A disintegrin and metalloproteinase with → A
GSK3A_HUMAN Glycogen synthase kinase-3 alpha → A
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SDIM1_HUMAN Stress-responsive DNAJB4-interacting membrane protein 1 → A

GLUCOSE Linkages


#18 HEPARAN contains 2 proteins

A4_HUMAN C31 → A : → G
GPC1_HUMAN Secreted glypican-1 → A : → G

HEPARAN Linkages


#19 HYPOVENTILATION contains 2 proteins

GDNF_HUMAN Glial cell line-derived neurotrophic factor → A : → G
TAU_HUMAN Microtubule-associated protein tau → A : → G

HYPOVENTILATION Linkages


#20 IRON contains 6 proteins

A4_HUMAN C31 → A : → G
HMGB1_HUMAN High mobility group protein B1 → A
PGH1_HUMAN Prostaglandin G/H synthase 1 → A
PGH2_HUMAN Prostaglandin G/H synthase 2 → A
PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component → A : → G
SYUA_HUMAN Alpha-synuclein → A : → G

IRON Linkages


#21 LACTIC contains 2 proteins

DNM1L_HUMAN Dynamin-1-like protein → A : → G
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G

LACTIC Linkages


#22 LEBER contains 2 proteins

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 → A : → G

LEBER Linkages


#23 LEUKEMIA contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
SPN90_HUMAN NCK-interacting protein with SH3 domain → A

LEUKEMIA Linkages


#24 LEWY contains 4 proteins

SQSTM_HUMAN Sequestosome-1 → A : → G
SYUA_HUMAN Alpha-synuclein → A : → G
SYUB_HUMAN Beta-synuclein → A
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

LEWY Linkages


#25 LUNG contains 22 proteins

APOE_HUMAN Apolipoprotein E → A : → G
ATS4_HUMAN A disintegrin and metalloproteinase with → A
BHLH9_HUMAN Protein BHLHb9 → A
COL12_HUMAN Collectin-12 → A
DHC24_HUMAN Delta(24)-sterol reductase → A : → G
DKK2_HUMAN Dickkopf-related protein 2 → A
DKK4_HUMAN Dickkopf-related protein 4 short form → A
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
FLNB_HUMAN Filamin-B → A : → G
GDNF_HUMAN Glial cell line-derived neurotrophic factor → A : → G
GPR3_HUMAN G-protein coupled receptor 3 → A
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
KC1D_HUMAN Casein kinase I isoform delta → A : → G
KLK8_HUMAN Kallikrein-8 → A
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
OLR1_HUMAN Oxidized low-density lipoprotein receptor 1, → A : → G
PREP_HUMAN Presequence protease, mitochondrial → A
PSA_HUMAN Puromycin-sensitive aminopeptidase → A
SORL_HUMAN Sortilin-related receptor → A : → G
SPN90_HUMAN NCK-interacting protein with SH3 domain → A
TNR21_HUMAN Tumor necrosis factor receptor superfamily → A
UBXN4_HUMAN UBX domain-containing protein 4 → A

LUNG Linkages


#26 MAGNESIUM contains 1 protein

CSEN_HUMAN Calsenilin → A : → G

MAGNESIUM Linkages


#27 MANGANESE contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
PREP_HUMAN Presequence protease, mitochondrial → A

MANGANESE Linkages


#28 MELANOMA contains 2 proteins

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G

MELANOMA Linkages


#29 MEMORY contains 4 proteins

KLK8_HUMAN Kallikrein-8 → A
NEUG_HUMAN NEUG(55-78) → A
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
TAU_HUMAN Microtubule-associated protein tau → A : → G

MEMORY Linkages


#30 MITOCHOND contains 13 proteins

A4_HUMAN C31 → A : → G
AATC_HUMAN Aspartate aminotransferase, cytoplasmic → A
CASP4_HUMAN Caspase-4 subunit 2 → A
DNM1L_HUMAN Dynamin-1-like protein → A : → G
HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2 → A : → G
HMGB1_HUMAN High mobility group protein B1 → A
HUNIN_HUMAN Humanin {ECO:0000305} → A
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 → A : → G
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
PREP_HUMAN Presequence protease, mitochondrial → A
TEFF2_HUMAN Tomoregulin-2 → A
TNR21_HUMAN Tumor necrosis factor receptor superfamily → A

MITOCHOND Linkages


#31 NYSTAGMUS contains 1 protein

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

NYSTAGMUS Linkages


#32 OPTIC contains 5 proteins

DNM1L_HUMAN Dynamin-1-like protein → A : → G
HMGB1_HUMAN High mobility group protein B1 → A
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 → A : → G
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

OPTIC Linkages


#33 OVARIAN contains 2 proteins

KLK8_HUMAN Kallikrein-8 → A
MARK1_HUMAN Serine/threonine-protein kinase MARK1 → A : → G

OVARIAN Linkages


#34 PALSY contains 1 protein

TAU_HUMAN Microtubule-associated protein tau → A : → G

PALSY Linkages


#35 PARKINSON contains 12 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
HRH2_HUMAN Histamine H2 receptor → A : → G
NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 → A : → G
PAWR_HUMAN PRKC apoptosis WT1 regulator protein → A
PCSK1_HUMAN Big LEN → A
PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component → A : → G
PSN1_HUMAN Presenilin-1 CTF12 → A : → G
SQSTM_HUMAN Sequestosome-1 → A : → G
SYUA_HUMAN Alpha-synuclein → A : → G
SYUB_HUMAN Beta-synuclein → A
TAU_HUMAN Microtubule-associated protein tau → A : → G
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

PARKINSON Linkages


#36 PICK contains 4 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
GPC1_HUMAN Secreted glypican-1 → A : → G
PCSK1_HUMAN Big LEN → A
TAU_HUMAN Microtubule-associated protein tau → A : → G

PICK Linkages


#37 PROSTATE contains 9 proteins

BACE2_HUMAN Beta-secretase 2 → A
DHC24_HUMAN Delta(24)-sterol reductase → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
FLNB_HUMAN Filamin-B → A : → G
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
SORL_HUMAN Sortilin-related receptor → A : → G
TEFF2_HUMAN Tomoregulin-2 → A
TNR21_HUMAN Tumor necrosis factor receptor superfamily → A

PROSTATE Linkages


#38 PSYCHIATRIC contains 2 proteins

HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2 → A : → G
HRH2_HUMAN Histamine H2 receptor → A : → G

PSYCHIATRIC Linkages


#39 PYRAMIDAL contains 3 proteins

DOCK3_HUMAN Dedicator of cytokinesis protein 3 → A
NEUG_HUMAN NEUG(55-78) → A
TAU_HUMAN Microtubule-associated protein tau → A : → G

PYRAMIDAL Linkages


#40 SENSORY contains 1 protein

CAHM1_HUMAN Calcium homeostasis modulator protein 1 → A

SENSORY Linkages


#41 SLEEP contains 1 protein

KC1D_HUMAN Casein kinase I isoform delta → A : → G

SLEEP Linkages


#42 SULFUR contains 1 protein

AATC_HUMAN Aspartate aminotransferase, cytoplasmic → A

SULFUR Linkages


#43 THYROID contains 2 proteins

FLNB_HUMAN Filamin-B → A : → G
SORL_HUMAN Sortilin-related receptor → A : → G

THYROID Linkages


#44 TREMOR contains 3 proteins

SYUA_HUMAN Alpha-synuclein → A : → G
TAU_HUMAN Microtubule-associated protein tau → A : → G
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

TREMOR Linkages


#45 UBIQUITIN contains 19 proteins

A4_HUMAN C31 → A : → G
CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1, → A
CDK5_HUMAN Cyclin-dependent-like kinase 5 → A
DNM1L_HUMAN Dynamin-1-like protein → A : → G
E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase → A : → G
FLNB_HUMAN Filamin-B → A : → G
GSK3B_HUMAN Glycogen synthase kinase-3 beta → A
HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain → A
KC1D_HUMAN Casein kinase I isoform delta → A : → G
LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 → A : → G
MARK1_HUMAN Serine/threonine-protein kinase MARK1 → A : → G
OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit → A : → G
RN146_HUMAN E3 ubiquitin-protein ligase RNF146 → A
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SQSTM_HUMAN Sequestosome-1 → A : → G
SYUA_HUMAN Alpha-synuclein → A : → G
TAU_HUMAN Microtubule-associated protein tau → A : → G
UBB_HUMAN Ubiquitin → A
UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 → A : → G

UBIQUITIN Linkages


#46 ZINC contains 17 proteins

A4_HUMAN C31 → A : → G
ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein → A : → G
ATS4_HUMAN A disintegrin and metalloproteinase with → A
BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF → A
ECE2_HUMAN Endothelin-converting enzyme 2 region → A
FOLH1_HUMAN Glutamate carboxypeptidase 2 → A : → G
MAZ_HUMAN Myc-associated zinc finger protein → A
MT3_HUMAN Metallothionein-3 → A
PREP_HUMAN Presequence protease, mitochondrial → A
PSA_HUMAN Puromycin-sensitive aminopeptidase → A
RN146_HUMAN E3 ubiquitin-protein ligase RNF146 → A
RN182_HUMAN E3 ubiquitin-protein ligase RNF182 → A : → G
SQSTM_HUMAN Sequestosome-1 → A : → G
SR1IP_HUMAN Protein SREK1IP1 → A
TSH1_HUMAN Teashirt homolog 1 → A
TSH2_HUMAN Teashirt homolog 2 → A
TSH3_HUMAN Teashirt homolog 3 → A

ZINC Linkages