Disease Motifs
Investigating the Biomechanics of Disease
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Go Sets

Set Theory with GO annotation.

There are 50 subsets from the Alzheimer's disease set so far but this may change as some sets maybe be merged together and other new sets may be created. If anyone would like to may any suggestions about, creating another set, deleting a set or merging two or more sets together, please feel free to do so. Some of these sets will be created in a very superficial way and have been grouped due to casual comments made by the person writing the details who just listed off symptoms on a particular protein's datasheet rather than listing specific, relevant and related details regarding a particular protein.



#1 ADENOCARCINOMA contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.


ADENOCARCINOMA Linkages


#2 AMYOTROPHIC contains 4 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.


AMYOTROPHIC Linkages


#3 APOPTOSIS contains 22 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

APBB1_HUMAN Amyloid beta A4 precursor protein-binding
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0043197; C:dendritic spine; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0030027; C:lamellipodium; IDA:UniProtKB.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
GO:0042734; C:presynaptic membrane; IEA:Ensembl.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0045202; C:synapse; IDA:UniProtKB.
GO:0001540; F:beta-amyloid binding; IPI:UniProtKB.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IPI:UniProtKB.
GO:0070064; F:proline-rich region binding; IPI:UniProtKB.
GO:0008134; F:transcription factor binding; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0007409; P:axonogenesis; NAS:UniProtKB.
GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
GO:0006302; P:double-strand break repair; IEA:Ensembl.
GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO:0050760; P:negative regulation of thymidylate synthase biosynthetic process; ISS:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO:0010039; P:response to iron ion; IEA:Ensembl.
GO:0007165; P:signal transduction; NAS:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

CASP4_HUMAN Caspase-4 subunit 2
GO:0097169; C:AIM2 inflammasome complex; IBA:GO_Central.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
GO:0005739; C:mitochondrion; IDA:ParkinsonsUK-UCL.
GO:0072559; C:NLRP3 inflammasome complex; IBA:GO_Central.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:ProtInc.
GO:1904646; P:cellular response to beta-amyloid; IMP:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; TAS:ProtInc.
GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.

CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1,
GO:0030424; C:axon; ISS:UniProtKB.
GO:0043292; C:contractile fiber; ISS:UniProtKB.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0043197; C:dendritic spine; ISS:UniProtKB.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045296; F:cadherin binding; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0016534; F:cyclin-dependent protein kinase 5 activator activity; IEA:Ensembl.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.
GO:0007411; P:axon guidance; ISS:UniProtKB.
GO:0007413; P:axonal fasciculation; ISS:UniProtKB.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0021549; P:cerebellum development; IEA:Ensembl.
GO:0009790; P:embryo development; IEA:Ensembl.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0007158; P:neuron cell-cell adhesion; ISS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.
GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

CSEN_HUMAN Calsenilin
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0061337; P:cardiac conduction; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

DHC24_HUMAN Delta(24)-sterol reductase
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; NAS:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0000246; F:delta24(24-1) sterol reductase activity; IMP:UniProtKB.
GO:0050614; F:delta24-sterol reductase activity; EXP:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IDA:MGI.
GO:0042605; F:peptide antigen binding; IPI:UniProtKB.
GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
GO:0006915; P:apoptotic process; NAS:UniProtKB.
GO:0007050; P:cell cycle arrest; NAS:UniProtKB.
GO:0006695; P:cholesterol biosynthetic process; ISS:UniProtKB.
GO:0033489; P:cholesterol biosynthetic process via desmosterol; TAS:Reactome.
GO:0033490; P:cholesterol biosynthetic process via lathosterol; TAS:Reactome.
GO:0030539; P:male genitalia development; IEA:Ensembl.
GO:0061024; P:membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0055114; P:oxidation-reduction process; IMP:UniProtKB.
GO:0031639; P:plasminogen activation; IEA:Ensembl.
GO:0008104; P:protein localization; IEA:Ensembl.
GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
GO:1901214; P:regulation of neuron death; NAS:UniProtKB.
GO:0009725; P:response to hormone; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEP:UniProtKB.
GO:0043588; P:skin development; ISS:UniProtKB.
GO:0009888; P:tissue development; IMP:UniProtKB.

DNM1L_HUMAN Dynamin-1-like protein
GO:0005903; C:brush border; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0030742; F:GTP-dependent protein binding; IDA:ParkinsonsUK-UCL.
GO:0005096; F:GTPase activator activity; IC:ParkinsonsUK-UCL.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0008017; F:microtubule binding; IBA:GO_Central.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0017137; F:Rab GTPase binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IDA:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
GO:0060047; P:heart contraction; IEA:Ensembl.
GO:0048312; P:intracellular distribution of mitochondria; IMP:ParkinsonsUK-UCL.
GO:0061025; P:membrane fusion; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
GO:0090149; P:mitochondrial membrane fission; IDA:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0016559; P:peroxisome fission; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IDA:UniProtKB.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0051259; P:protein oligomerization; IMP:UniProtKB.
GO:1903578; P:regulation of ATP metabolic process; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; IGI:ParkinsonsUK-UCL.
GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0097452; C:GAIT complex; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB.
GO:0005811; C:lipid particle; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0031982; C:vesicle; IDA:UniProtKB.
GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; ISS:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008017; F:microtubule binding; ISS:UniProtKB.
GO:0051287; F:NAD binding; IEA:InterPro.
GO:0050661; F:NADP binding; IEA:InterPro.
GO:0035605; F:peptidyl-cysteine S-nitrosylase activity; ISS:UniProtKB.
GO:0061621; P:canonical glycolysis; TAS:Reactome.
GO:0071346; P:cellular response to interferon-gamma; IDA:UniProtKB.
GO:0006094; P:gluconeogenesis; TAS:Reactome.
GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0035606; P:peptidyl-cysteine S-trans-nitrosylation; ISS:UniProtKB.
GO:0050821; P:protein stabilization; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.

GSK3A_HUMAN Glycogen synthase kinase-3 alpha
GO:0030877; C:beta-catenin destruction complex; TAS:UniProtKB.
GO:0005829; C:cytosol; TAS:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0003214; P:cardiac left ventricle morphogenesis; ISS:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; ISS:BHF-UCL.
GO:0046325; P:negative regulation of glucose import; IMP:BHF-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:1904227; P:negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; IMP:BHF-UCL.
GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO:0032007; P:negative regulation of TOR signaling; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0010905; P:negative regulation of UDP-glucose catabolic process; IC:UniProtKB.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:BHF-UCL.
GO:2000467; P:positive regulation of glycogen (starch) synthase activity; ISS:BHF-UCL.
GO:0045823; P:positive regulation of heart contraction; ISS:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; NAS:BHF-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:BHF-UCL.
GO:1903146; P:regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

HUNIN_HUMAN Humanin {ECO:0000305}
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0048019; F:receptor antagonist activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; TAS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.
GO:0030595; P:leukocyte chemotaxis; IDA:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

OLR1_HUMAN Oxidized low-density lipoprotein receptor 1,
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO:0005041; F:low-density lipoprotein receptor activity; IEA:Ensembl.
GO:0008015; P:blood circulation; TAS:ProtInc.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0050900; P:leukocyte migration; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PGH2_HUMAN Prostaglandin G/H synthase 2
GO:0005901; C:caveola; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005788; C:endoplasmic reticulum lumen; TAS:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0050473; F:arachidonate 15-lipoxygenase activity; TAS:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0020037; F:heme binding; ISS:UniProtKB.
GO:0008289; F:lipid binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; NAS:UniProtKB.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; IEA:Ensembl.
GO:0030282; P:bone mineralization; IEA:Ensembl.
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
GO:0071318; P:cellular response to ATP; IEA:Ensembl.
GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0046697; P:decidualization; IEA:Ensembl.
GO:0007566; P:embryo implantation; IEA:Ensembl.
GO:0042633; P:hair cycle; IEA:Ensembl.
GO:0006954; P:inflammatory response; IEA:Ensembl.
GO:0007612; P:learning; IEA:Ensembl.
GO:0019372; P:lipoxygenase pathway; TAS:Reactome.
GO:0035633; P:maintenance of permeability of blood-brain barrier; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO:0032227; P:negative regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0006769; P:nicotinamide metabolic process; TAS:Reactome.
GO:0030728; P:ovulation; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:BHF-UCL.
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.
GO:0031622; P:positive regulation of fever generation; ISS:BHF-UCL.
GO:0090271; P:positive regulation of fibroblast growth factor production; ISS:BHF-UCL.
GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
GO:0090362; P:positive regulation of platelet-derived growth factor production; ISS:BHF-UCL.
GO:0031394; P:positive regulation of prostaglandin biosynthetic process; NAS:BHF-UCL.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:BHF-UCL.
GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:BHF-UCL.
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0006693; P:prostaglandin metabolic process; TAS:ProtInc.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0050727; P:regulation of inflammatory response; NAS:UniProtKB.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO:0009750; P:response to fructose; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0010226; P:response to lithium ion; IEA:Ensembl.
GO:0010042; P:response to manganese ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SDIM1_HUMAN Stress-responsive DNAJB4-interacting membrane protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0033554; P:cellular response to stress; IEP:UniProtKB.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:0051402; P:neuron apoptotic process; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TNR21_HUMAN Tumor necrosis factor receptor superfamily
GO:0030424; C:axon; IEA:Ensembl.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO:0002250; P:adaptive immune response; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO:0001783; P:B cell apoptotic process; ISS:UniProtKB.
GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
GO:0006959; P:humoral immune response; ISS:UniProtKB.
GO:0006955; P:immune response; IBA:GO_Central.
GO:0006954; P:inflammatory response; IBA:GO_Central.
GO:0042552; P:myelination; ISS:UniProtKB.
GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO:2001180; P:negative regulation of interleukin-10 secretion; ISS:UniProtKB.
GO:2000666; P:negative regulation of interleukin-13 secretion; ISS:UniProtKB.
GO:2000663; P:negative regulation of interleukin-5 secretion; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; IMP:UniProtKB.
GO:0042130; P:negative regulation of T cell proliferation; ISS:UniProtKB.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0097252; P:oligodendrocyte apoptotic process; ISS:UniProtKB.
GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.


APOPTOSIS Linkages


#4 ATAXIA contains 1 protein

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


ATAXIA Linkages


#5 BEHAV contains 6 proteins

DOCK3_HUMAN Dedicator of cytokinesis protein 3
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.

GPR3_HUMAN G-protein coupled receptor 3
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl.

HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:ProtInc.
GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome.
GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; IEA:UniProtKB-EC.
GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
GO:0006629; P:lipid metabolic process; TAS:ProtInc.
GO:0070901; P:mitochondrial tRNA methylation; TAS:Reactome.
GO:0090646; P:mitochondrial tRNA processing; TAS:Reactome.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


BEHAV Linkages


#6 BREAST contains 12 proteins

BACE2_HUMAN Beta-secretase 2
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:UniProtKB.
GO:0001540; F:beta-amyloid binding; IBA:GO_Central.
GO:0050435; P:beta-amyloid metabolic process; IBA:GO_Central.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IMP:UniProtKB.
GO:0016486; P:peptide hormone processing; NAS:UniProtKB.
GO:0030163; P:protein catabolic process; IBA:GO_Central.
GO:0006508; P:proteolysis; NAS:UniProtKB.

CATD_HUMAN Cathepsin D heavy chain
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; TAS:ProtInc.
GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0006914; P:autophagy; IBA:GO_Central.
GO:0030574; P:collagen catabolic process; TAS:Reactome.
GO:0030163; P:protein catabolic process; IBA:GO_Central.

CSEN_HUMAN Calsenilin
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0061337; P:cardiac conduction; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

GPC1_HUMAN Secreted glypican-1
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0005796; C:Golgi lumen; TAS:Reactome.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005578; C:proteinaceous extracellular matrix; ISS:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:InterPro.
GO:0043236; F:laminin binding; ISS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
GO:0030203; P:glycosaminoglycan metabolic process; TAS:Reactome.
GO:0030200; P:heparan sulfate proteoglycan catabolic process; IDA:UniProtKB.
GO:0032288; P:myelin assembly; ISS:UniProtKB.
GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0014037; P:Schwann cell differentiation; ISS:UniProtKB.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.


BREAST Linkages


#7 CALCIUM contains 12 proteins

CAHM1_HUMAN Calcium homeostasis modulator protein 1
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0005227; F:calcium activated cation channel activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
GO:0005244; F:voltage-gated ion channel activity; IDA:UniProtKB.
GO:0015867; P:ATP transport; ISS:UniProtKB.
GO:0006812; P:cation transport; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0034765; P:regulation of ion transmembrane transport; IDA:UniProtKB.
GO:0050913; P:sensory perception of bitter taste; ISS:UniProtKB.
GO:0050916; P:sensory perception of sweet taste; ISS:UniProtKB.
GO:0050917; P:sensory perception of umami taste; ISS:UniProtKB.

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

COL12_HUMAN Collectin-12
GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005534; F:galactose binding; NAS:UniProtKB.
GO:0030169; F:low-density lipoprotein particle binding; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005044; F:scavenger receptor activity; TAS:UniProtKB.
GO:0008329; F:signaling pattern recognition receptor activity; IDA:UniProtKB.
GO:0009756; P:carbohydrate mediated signaling; NAS:UniProtKB.
GO:0071360; P:cellular response to exogenous dsRNA; IMP:UniProtKB.
GO:0006952; P:defense response; TAS:UniProtKB.
GO:0045087; P:innate immune response; TAS:UniProtKB.
GO:0006910; P:phagocytosis, recognition; IDA:UniProtKB.
GO:0060355; P:positive regulation of cell adhesion molecule production; IMP:UniProtKB.
GO:0051260; P:protein homooligomerization; NAS:UniProtKB.
GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome.
GO:0034138; P:toll-like receptor 3 signaling pathway; IMP:UniProtKB.

CSEN_HUMAN Calsenilin
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0061337; P:cardiac conduction; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

CSTN1_HUMAN CTF1-alpha
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO:0001540; F:beta-amyloid binding; IDA:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0042988; F:X11-like protein binding; IPI:UniProtKB.
GO:0007155; P:cell adhesion; TAS:UniProtKB.
GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
GO:0050806; P:positive regulation of synaptic transmission; IEA:Ensembl.
GO:0001558; P:regulation of cell growth; IEA:Ensembl.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

LRP8_HUMAN Low-density lipoprotein receptor-related protein 8
GO:0030424; C:axon; IEA:Ensembl.
GO:0005901; C:caveola; IDA:BHF-UCL.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IC:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005875; C:microtubule associated complex; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0034185; F:apolipoprotein binding; IC:BHF-UCL.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO:0005041; F:low-density lipoprotein receptor activity; TAS:Reactome.
GO:0038025; F:reelin receptor activity; ISS:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0030229; F:very-low-density lipoprotein particle receptor activity; IDA:BHF-UCL.
GO:0021541; P:ammon gyrus development; ISS:BHF-UCL.
GO:0071397; P:cellular response to cholesterol; IEA:Ensembl.
GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
GO:0006897; P:endocytosis; IDA:UniProtKB.
GO:0006629; P:lipid metabolic process; NAS:UniProtKB.
GO:0050804; P:modulation of synaptic transmission; ISS:BHF-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0032793; P:positive regulation of CREB transcription factor activity; ISS:BHF-UCL.
GO:1900006; P:positive regulation of dendrite development; ISS:BHF-UCL.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:BHF-UCL.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:BHF-UCL.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISS:BHF-UCL.
GO:0006508; P:proteolysis; NAS:UniProtKB.
GO:0038026; P:reelin-mediated signaling pathway; ISS:BHF-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.

NEUG_HUMAN NEUG(55-78)
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0012510; C:trans-Golgi network transport vesicle membrane; IEA:Ensembl.
GO:0005516; F:calmodulin binding; TAS:ProtInc.
GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
GO:0008306; P:associative learning; IEA:Ensembl.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:1900273; P:positive regulation of long-term synaptic potentiation; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0021537; P:telencephalon development; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

REG1A_HUMAN Lithostathine-1-alpha
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO:0008083; F:growth factor activity; IDA:MGI.
GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.

UBXN4_HUMAN UBX domain-containing protein 4
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.

VISL1_HUMAN Visinin-like protein 1
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0016020; C:membrane; IEA:Ensembl.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.


CALCIUM Linkages


#8 CANCER contains 25 proteins

BHLH9_HUMAN Protein BHLHb9
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0007611; P:learning or memory; ISS:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.

CATD_HUMAN Cathepsin D heavy chain
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; TAS:ProtInc.
GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0006914; P:autophagy; IBA:GO_Central.
GO:0030574; P:collagen catabolic process; TAS:Reactome.
GO:0030163; P:protein catabolic process; IBA:GO_Central.

CSEN_HUMAN Calsenilin
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0061337; P:cardiac conduction; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

DKK1_HUMAN Dickkopf-related protein 1
GO:0031901; C:early endosome membrane; TAS:Reactome.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0005886; C:plasma membrane; IDA:MGI.
GO:0039706; F:co-receptor binding; IPI:ParkinsonsUK-UCL.
GO:0008083; F:growth factor activity; TAS:ProtInc.
GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI.
GO:0048019; F:receptor antagonist activity; IDA:BHF-UCL.
GO:0004871; F:signal transducer activity; TAS:ProtInc.
GO:0000904; P:cell morphogenesis involved in differentiation; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0001706; P:endoderm formation; IEA:Ensembl.
GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0001942; P:hair follicle development; IEA:Ensembl.
GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO:0061743; P:motor learning; IEA:Ensembl.
GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO:1901296; P:negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; IDA:BHF-UCL.
GO:2000726; P:negative regulation of cardiac muscle cell differentiation; IDA:BHF-UCL.
GO:0042662; P:negative regulation of mesodermal cell fate specification; IDA:BHF-UCL.
GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO:0032091; P:negative regulation of protein binding; IDA:ParkinsonsUK-UCL.
GO:0048642; P:negative regulation of skeletal muscle tissue development; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:UniProtKB.
GO:1904723; P:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; IDA:ParkinsonsUK-UCL.
GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; ISS:BHF-UCL.
GO:1904958; P:positive regulation of midbrain dopaminergic neuron differentiation; IEA:Ensembl.
GO:1904338; P:regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:0042663; P:regulation of endodermal cell fate specification; IDA:BHF-UCL.
GO:0002090; P:regulation of receptor internalization; IDA:BHF-UCL.
GO:0050807; P:regulation of synapse organization; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO:0098883; P:synapse disassembly; TAS:ParkinsonsUK-UCL.
GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IEA:Ensembl.

DKK2_HUMAN Dickkopf-related protein 2
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

DKK3_HUMAN Dickkopf-related protein 3
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030325; P:adrenal gland development; IEP:UniProtKB.
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO:0032348; P:negative regulation of aldosterone biosynthetic process; IDA:UniProtKB.
GO:1902613; P:negative regulation of anti-Mullerian hormone signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO:2000065; P:negative regulation of cortisol biosynthetic process; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

DKK4_HUMAN Dickkopf-related protein 4 short form
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0061170; P:negative regulation of hair follicle placode formation; IEA:Ensembl.
GO:0030178; P:negative regulation of Wnt signaling pathway; NAS:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

DPYL2_HUMAN Dihydropyrimidinase-related protein 2
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0004157; F:dihydropyrimidinase activity; TAS:ProtInc.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0007411; P:axon guidance; IEA:InterPro.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0006897; P:endocytosis; IMP:UniProtKB.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc.
GO:0021772; P:olfactory bulb development; IEA:Ensembl.
GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
GO:0030516; P:regulation of axon extension; IEA:InterPro.
GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0021510; P:spinal cord development; IEA:Ensembl.
GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

GPC1_HUMAN Secreted glypican-1
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0005796; C:Golgi lumen; TAS:Reactome.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005578; C:proteinaceous extracellular matrix; ISS:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:InterPro.
GO:0043236; F:laminin binding; ISS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
GO:0030203; P:glycosaminoglycan metabolic process; TAS:Reactome.
GO:0030200; P:heparan sulfate proteoglycan catabolic process; IDA:UniProtKB.
GO:0032288; P:myelin assembly; ISS:UniProtKB.
GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0014037; P:Schwann cell differentiation; ISS:UniProtKB.

GSAP_HUMAN Gamma-secretase-activating protein 16 kDa C-terminal
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0001540; F:beta-amyloid binding; IDA:UniProtKB.
GO:1902004; P:positive regulation of beta-amyloid formation; IDA:UniProtKB.
GO:0030162; P:regulation of proteolysis; IDA:UniProtKB.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

NDRG2_HUMAN Protein NDRG2
GO:0005813; C:centrosome; IDA:HPA.
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; NAS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0090361; P:regulation of platelet-derived growth factor production; IEA:Ensembl.
GO:0010574; P:regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO:0007165; P:signal transduction; IBA:GO_Central.
GO:0021762; P:substantia nigra development; IEP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PGH1_HUMAN Prostaglandin G/H synthase 1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
GO:0020037; F:heme binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; TAS:Reactome.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:BHF-UCL.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0006954; P:inflammatory response; IEA:InterPro.
GO:0006629; P:lipid metabolic process; NAS:ProtInc.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.

PGH2_HUMAN Prostaglandin G/H synthase 2
GO:0005901; C:caveola; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005788; C:endoplasmic reticulum lumen; TAS:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0050473; F:arachidonate 15-lipoxygenase activity; TAS:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0020037; F:heme binding; ISS:UniProtKB.
GO:0008289; F:lipid binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; NAS:UniProtKB.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; IEA:Ensembl.
GO:0030282; P:bone mineralization; IEA:Ensembl.
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
GO:0071318; P:cellular response to ATP; IEA:Ensembl.
GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0046697; P:decidualization; IEA:Ensembl.
GO:0007566; P:embryo implantation; IEA:Ensembl.
GO:0042633; P:hair cycle; IEA:Ensembl.
GO:0006954; P:inflammatory response; IEA:Ensembl.
GO:0007612; P:learning; IEA:Ensembl.
GO:0019372; P:lipoxygenase pathway; TAS:Reactome.
GO:0035633; P:maintenance of permeability of blood-brain barrier; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO:0032227; P:negative regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0006769; P:nicotinamide metabolic process; TAS:Reactome.
GO:0030728; P:ovulation; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:BHF-UCL.
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.
GO:0031622; P:positive regulation of fever generation; ISS:BHF-UCL.
GO:0090271; P:positive regulation of fibroblast growth factor production; ISS:BHF-UCL.
GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
GO:0090362; P:positive regulation of platelet-derived growth factor production; ISS:BHF-UCL.
GO:0031394; P:positive regulation of prostaglandin biosynthetic process; NAS:BHF-UCL.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:BHF-UCL.
GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:BHF-UCL.
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0006693; P:prostaglandin metabolic process; TAS:ProtInc.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0050727; P:regulation of inflammatory response; NAS:UniProtKB.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO:0009750; P:response to fructose; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0010226; P:response to lithium ion; IEA:Ensembl.
GO:0010042; P:response to manganese ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.

TEFF2_HUMAN Tomoregulin-2
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO:0045720; P:negative regulation of integrin biosynthetic process; IMP:MGI.
GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
GO:0044319; P:wound healing, spreading of cells; IDA:MGI.


CANCER Linkages


#9 CARCINOMA contains 10 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

RBG1L_HUMAN Rab GTPase-activating protein 1-like
GO:0005769; C:early endosome; IDA:MGI.
GO:0005794; C:Golgi apparatus; IDA:MGI.
GO:0005634; C:nucleus; IDA:MGI.
GO:0005096; F:GTPase activator activity; IDA:MGI.
GO:0017137; F:Rab GTPase binding; IDA:BHF-UCL.
GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO:0032880; P:regulation of protein localization; IDA:MGI.
GO:0031338; P:regulation of vesicle fusion; IBA:GO_Central.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

TEFF2_HUMAN Tomoregulin-2
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO:0045720; P:negative regulation of integrin biosynthetic process; IMP:MGI.
GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
GO:0044319; P:wound healing, spreading of cells; IDA:MGI.


CARCINOMA Linkages


#10 CARDIOMYOPATHY contains 3 proteins

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

PSN2_HUMAN Presenilin-2 CTF subunit
GO:0016324; C:apical plasma membrane; IBA:GO_Central.
GO:0005938; C:cell cortex; IBA:GO_Central.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IDA:HGNC.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030018; C:Z disc; IBA:GO_Central.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0050435; P:beta-amyloid metabolic process; IBA:GO_Central.
GO:0006816; P:calcium ion transport; IBA:GO_Central.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome.
GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; TAS:Reactome.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0001666; P:response to hypoxia; IEA:Ensembl.


CARDIOMYOPATHY Linkages


#11 COLORECTAL contains 5 proteins

DPYL2_HUMAN Dihydropyrimidinase-related protein 2
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0004157; F:dihydropyrimidinase activity; TAS:ProtInc.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0007411; P:axon guidance; IEA:InterPro.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0006897; P:endocytosis; IMP:UniProtKB.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc.
GO:0021772; P:olfactory bulb development; IEA:Ensembl.
GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
GO:0030516; P:regulation of axon extension; IEA:InterPro.
GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO:0042220; P:response to cocaine; IEA:Ensembl.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0021510; P:spinal cord development; IEA:Ensembl.
GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.

TEFF2_HUMAN Tomoregulin-2
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO:0045720; P:negative regulation of integrin biosynthetic process; IMP:MGI.
GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
GO:0044319; P:wound healing, spreading of cells; IDA:MGI.


COLORECTAL Linkages


#12 COPPER contains 3 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

MT3_HUMAN Metallothionein-3
GO:0097450; C:astrocyte end-foot; IEA:Ensembl.
GO:0030424; C:axon; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043197; C:dendritic spine; IEA:Ensembl.
GO:0005615; C:extracellular space; IEA:Ensembl.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005622; C:intracellular; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:Ensembl.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO:0016209; F:antioxidant activity; NAS:UniProtKB.
GO:0046870; F:cadmium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0008144; F:drug binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0014002; P:astrocyte development; ISS:UniProtKB.
GO:0007420; P:brain development; IEA:Ensembl.
GO:0055073; P:cadmium ion homeostasis; IDA:UniProtKB.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0044242; P:cellular lipid catabolic process; ISS:UniProtKB.
GO:0006875; P:cellular metal ion homeostasis; NAS:UniProtKB.
GO:0071276; P:cellular response to cadmium ion; IDA:UniProtKB.
GO:0035690; P:cellular response to drug; IDA:UniProtKB.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071732; P:cellular response to nitric oxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IEP:UniProtKB.
GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
GO:0006707; P:cholesterol catabolic process; ISS:UniProtKB.
GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
GO:0070371; P:ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0016570; P:histone modification; IMP:UniProtKB.
GO:0033210; P:leptin-mediated signaling pathway; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:0010507; P:negative regulation of autophagy; ISS:UniProtKB.
GO:0030517; P:negative regulation of axon extension; IDA:UniProtKB.
GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2000296; P:negative regulation of hydrogen peroxide catabolic process; IEA:Ensembl.
GO:0060547; P:negative regulation of necrotic cell death; IDA:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0051354; P:negative regulation of oxidoreductase activity; IDA:UniProtKB.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0097214; P:positive regulation of lysosomal membrane permeability; ISS:UniProtKB.
GO:0010940; P:positive regulation of necrotic cell death; IDA:UniProtKB.
GO:2000376; P:positive regulation of oxygen metabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:UniProtKB.
GO:0036091; P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0000060; P:protein import into nucleus, translocation; IDA:UniProtKB.
GO:0043491; P:protein kinase B signaling; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IDA:UniProtKB.
GO:0060049; P:regulation of protein glycosylation; ISS:UniProtKB.
GO:0032095; P:regulation of response to food; ISS:UniProtKB.
GO:0019430; P:removal of superoxide radicals; IDA:UniProtKB.
GO:0001666; P:response to hypoxia; IDA:UniProtKB.
GO:0010038; P:response to metal ion; TAS:Reactome.
GO:0006829; P:zinc II ion transport; ISS:UniProtKB.
GO:0055069; P:zinc ion homeostasis; IDA:UniProtKB.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.


COPPER Linkages


#13 DEMENTIA contains 16 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

AATF_HUMAN Protein AATF
GO:0005813; C:centrosome; IDA:HPA.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:HPA.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0005730; C:nucleolus; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO:0007155; P:cell adhesion; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB.
GO:0040016; P:embryonic cleavage; IEA:Ensembl.
GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0032929; P:negative regulation of superoxide anion generation; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
GO:0042254; P:ribosome biogenesis; IEA:Ensembl.

ABCA7_HUMAN ATP-binding cassette sub-family A member
GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO:0043190; C:ATP-binding cassette (ABC) transporter complex; TAS:ProtInc.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; ISS:Alzheimers_University_of_Toronto.
GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
GO:0001891; C:phagocytic cup; ISS:Alzheimers_University_of_Toronto.
GO:0005886; C:plasma membrane; IDA:Alzheimers_University_of_Toronto.
GO:0032587; C:ruffle membrane; ISS:Alzheimers_University_of_Toronto.
GO:0034188; F:apolipoprotein A-I receptor activity; IDA:Alzheimers_University_of_Toronto.
GO:0005524; F:ATP binding; TAS:ProtInc.
GO:0016887; F:ATPase activity; IDA:BHF-UCL.
GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
GO:0090554; F:phosphatidylcholine-translocating ATPase activity; IDA:BHF-UCL.
GO:0090556; F:phosphatidylserine-translocating ATPase activity; IDA:BHF-UCL.
GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0038027; P:apolipoprotein A-I-mediated signaling pathway; IDA:Alzheimers_University_of_Toronto.
GO:0033344; P:cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
GO:0034380; P:high-density lipoprotein particle assembly; IDA:Alzheimers_University_of_Toronto.
GO:0007613; P:memory; ISS:Alzheimers_University_of_Toronto.
GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; ISS:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; ISS:Alzheimers_University_of_Toronto.
GO:0018149; P:peptide cross-linking; ISS:Alzheimers_University_of_Toronto.
GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
GO:0033700; P:phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
GO:0045332; P:phospholipid translocation; IDA:BHF-UCL.
GO:1900223; P:positive regulation of beta-amyloid clearance; ISS:Alzheimers_University_of_Toronto.
GO:0010875; P:positive regulation of cholesterol efflux; ISS:Alzheimers_University_of_Toronto.
GO:1901076; P:positive regulation of engulfment of apoptotic cell; ISS:Alzheimers_University_of_Toronto.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:Alzheimers_University_of_Toronto.
GO:0050766; P:positive regulation of phagocytosis; ISS:Alzheimers_University_of_Toronto.
GO:1902995; P:positive regulation of phospholipid efflux; ISS:Alzheimers_University_of_Toronto.
GO:0034504; P:protein localization to nucleus; ISS:Alzheimers_University_of_Toronto.
GO:0055085; P:transmembrane transport; TAS:Reactome.

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005798; C:Golgi-associated vesicle; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0097038; C:perinuclear endoplasmic reticulum; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0097197; C:tetraspanin-enriched microdomain; IDA:UniProtKB.
GO:0004175; F:endopeptidase activity; ISS:UniProtKB.
GO:0005178; F:integrin binding; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO:0005102; F:receptor binding; NAS:UniProtKB.
GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
GO:0051089; P:constitutive protein ectodomain proteolysis; IDA:UniProtKB.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042117; P:monocyte activation; IMP:BHF-UCL.
GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.
GO:0007220; P:Notch receptor processing; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IMP:BHF-UCL.
GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL.
GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
GO:0010820; P:positive regulation of T cell chemotaxis; IMP:BHF-UCL.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0016485; P:protein processing; IEA:Ensembl.
GO:0034612; P:response to tumor necrosis factor; IDA:BHF-UCL.

APOE_HUMAN Apolipoprotein E
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0042627; C:chylomicron; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0030425; C:dendrite; NAS:BHF-UCL.
GO:0005769; C:early endosome; TAS:Reactome.
GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
GO:0005783; C:endoplasmic reticulum; IDA:AgBase.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:AgBase.
GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
GO:0034363; C:intermediate-density lipoprotein particle; IDA:BHF-UCL.
GO:0034362; C:low-density lipoprotein particle; IDA:BHF-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; NAS:BHF-UCL.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
GO:0016209; F:antioxidant activity; IDA:BHF-UCL.
GO:0001540; F:beta-amyloid binding; IDA:UniProtKB.
GO:0015485; F:cholesterol binding; IBA:GO_Central.
GO:0017127; F:cholesterol transporter activity; IBA:GO_Central.
GO:0008201; F:heparin binding; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IDA:BHF-UCL.
GO:0008289; F:lipid binding; IDA:UniProtKB.
GO:0005319; F:lipid transporter activity; IDA:BHF-UCL.
GO:0071813; F:lipoprotein particle binding; IEA:Ensembl.
GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
GO:0046911; F:metal chelating activity; IDA:BHF-UCL.
GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL.
GO:0005543; F:phospholipid binding; IDA:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.
GO:0048156; F:tau protein binding; IPI:BHF-UCL.
GO:0070326; F:very-low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
GO:0097113; P:AMPA glutamate receptor clustering; IDA:Alzheimers_University_of_Toronto.
GO:0048844; P:artery morphogenesis; IEA:Ensembl.
GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO:0019934; P:cGMP-mediated signaling; IDA:BHF-UCL.
GO:0006707; P:cholesterol catabolic process; IBA:GO_Central.
GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL.
GO:0034382; P:chylomicron remnant clearance; IMP:BHF-UCL.
GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.
GO:0055089; P:fatty acid homeostasis; IDA:Alzheimers_University_of_Toronto.
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL.
GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
GO:0034375; P:high-density lipoprotein particle remodeling; IGI:BHF-UCL.
GO:0046907; P:intracellular transport; TAS:UniProtKB.
GO:0010877; P:lipid transport involved in lipid storage; ISS:BHF-UCL.
GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
GO:0042159; P:lipoprotein catabolic process; IBA:GO_Central.
GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
GO:0015909; P:long-chain fatty acid transport; IDA:Alzheimers_University_of_Toronto.
GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
GO:0051651; P:maintenance of location in cell; IEA:Ensembl.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0030195; P:negative regulation of blood coagulation; IDA:BHF-UCL.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0045541; P:negative regulation of cholesterol biosynthetic process; IDA:BHF-UCL.
GO:0090370; P:negative regulation of cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
GO:0061000; P:negative regulation of dendritic spine development; IDA:Alzheimers_University_of_Toronto.
GO:1902951; P:negative regulation of dendritic spine maintenance; IDA:Alzheimers_University_of_Toronto.
GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
GO:0051055; P:negative regulation of lipid biosynthetic process; IDA:Alzheimers_University_of_Toronto.
GO:1903001; P:negative regulation of lipid transport across blood brain barrier; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
GO:1901215; P:negative regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:1902999; P:negative regulation of phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1901627; P:negative regulation of postsynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:1901630; P:negative regulation of presynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:0031102; P:neuron projection regeneration; IBA:GO_Central.
GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL.
GO:0097114; P:NMDA glutamate receptor clustering; IDA:Alzheimers_University_of_Toronto.
GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
GO:0044794; P:positive regulation by host of viral process; IMP:AgBase.
GO:1902004; P:positive regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0030828; P:positive regulation of cGMP biosynthetic process; IDA:BHF-UCL.
GO:0010875; P:positive regulation of cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL.
GO:0060999; P:positive regulation of dendritic spine development; IDA:Alzheimers_University_of_Toronto.
GO:1902952; P:positive regulation of dendritic spine maintenance; IDA:Alzheimers_University_of_Toronto.
GO:0046889; P:positive regulation of lipid biosynthetic process; IDA:Alzheimers_University_of_Toronto.
GO:1903002; P:positive regulation of lipid transport across blood brain barrier; IDA:Alzheimers_University_of_Toronto.
GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL.
GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.
GO:1902998; P:positive regulation of neurofibrillary tangle assembly; IDA:Alzheimers_University_of_Toronto.
GO:1901216; P:positive regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
GO:1902995; P:positive regulation of phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
GO:1901628; P:positive regulation of postsynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:1901631; P:positive regulation of presynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:0017038; P:protein import; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; IDA:BHF-UCL.
GO:0030516; P:regulation of axon extension; TAS:UniProtKB.
GO:1900221; P:regulation of beta-amyloid clearance; IDA:Alzheimers_University_of_Toronto.
GO:0032489; P:regulation of Cdc42 protein signal transduction; IDA:BHF-UCL.
GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO:1901214; P:regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:0048168; P:regulation of neuronal synaptic plasticity; TAS:UniProtKB.
GO:1902947; P:regulation of tau-protein kinase activity; IDA:Alzheimers_University_of_Toronto.
GO:0002021; P:response to dietary excess; IEA:Ensembl.
GO:0000302; P:response to reactive oxygen species; NAS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL.
GO:0007271; P:synaptic transmission, cholinergic; TAS:UniProtKB.
GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL.
GO:0006641; P:triglyceride metabolic process; IDA:BHF-UCL.
GO:0042311; P:vasodilation; IEA:Ensembl.
GO:0034447; P:very-low-density lipoprotein particle clearance; IDA:BHF-UCL.
GO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL.
GO:0019068; P:virion assembly; IMP:AgBase.

CATD_HUMAN Cathepsin D heavy chain
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; TAS:ProtInc.
GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0006914; P:autophagy; IBA:GO_Central.
GO:0030574; P:collagen catabolic process; TAS:Reactome.
GO:0030163; P:protein catabolic process; IBA:GO_Central.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

PSN2_HUMAN Presenilin-2 CTF subunit
GO:0016324; C:apical plasma membrane; IBA:GO_Central.
GO:0005938; C:cell cortex; IBA:GO_Central.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IDA:HGNC.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030018; C:Z disc; IBA:GO_Central.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0050435; P:beta-amyloid metabolic process; IBA:GO_Central.
GO:0006816; P:calcium ion transport; IBA:GO_Central.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome.
GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; TAS:Reactome.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0001666; P:response to hypoxia; IEA:Ensembl.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


DEMENTIA Linkages


#14 DIABETES contains 6 proteins

GSK3A_HUMAN Glycogen synthase kinase-3 alpha
GO:0030877; C:beta-catenin destruction complex; TAS:UniProtKB.
GO:0005829; C:cytosol; TAS:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0003214; P:cardiac left ventricle morphogenesis; ISS:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; ISS:BHF-UCL.
GO:0046325; P:negative regulation of glucose import; IMP:BHF-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:1904227; P:negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; IMP:BHF-UCL.
GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO:0032007; P:negative regulation of TOR signaling; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0010905; P:negative regulation of UDP-glucose catabolic process; IC:UniProtKB.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:BHF-UCL.
GO:2000467; P:positive regulation of glycogen (starch) synthase activity; ISS:BHF-UCL.
GO:0045823; P:positive regulation of heart contraction; ISS:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; NAS:BHF-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:BHF-UCL.
GO:1903146; P:regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

OLR1_HUMAN Oxidized low-density lipoprotein receptor 1,
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO:0005041; F:low-density lipoprotein receptor activity; IEA:Ensembl.
GO:0008015; P:blood circulation; TAS:ProtInc.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0050900; P:leukocyte migration; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.


DIABETES Linkages


#15 DOWN-REGULATED contains 7 proteins

BHLH9_HUMAN Protein BHLHb9
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0007611; P:learning or memory; ISS:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.

ECE2_HUMAN Endothelin-converting enzyme 2 region
GO:0030659; C:cytoplasmic vesicle membrane; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0010002; P:cardioblast differentiation; ISS:UniProtKB.
GO:0007267; P:cell-cell signaling; TAS:UniProtKB.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0016486; P:peptide hormone processing; IDA:UniProtKB.

P33MX_HUMAN Putative monooxygenase p33MONOX
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.

SDIM1_HUMAN Stress-responsive DNAJB4-interacting membrane protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0033554; P:cellular response to stress; IEP:UniProtKB.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:0051402; P:neuron apoptotic process; IDA:UniProtKB.

SR1IP_HUMAN Protein SREK1IP1
GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

VP26A_HUMAN Vacuolar protein sorting-associated protein 26A
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0030904; C:retromer complex; IDA:ParkinsonsUK-UCL.
GO:0030906; C:retromer, cargo-selective complex; IDA:ParkinsonsUK-UCL.
GO:0097422; C:tubular endosome; IDA:UniProtKB.
GO:0031982; C:vesicle; IDA:UniProtKB.
GO:0008565; F:protein transporter activity; NAS:UniProtKB.
GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
GO:1990126; P:retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.


DOWN-REGULATED Linkages


#16 EXTRAPYRAMIDAL contains 1 protein

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


EXTRAPYRAMIDAL Linkages


#17 FINGER contains 12 proteins

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005798; C:Golgi-associated vesicle; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0097038; C:perinuclear endoplasmic reticulum; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0097197; C:tetraspanin-enriched microdomain; IDA:UniProtKB.
GO:0004175; F:endopeptidase activity; ISS:UniProtKB.
GO:0005178; F:integrin binding; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO:0005102; F:receptor binding; NAS:UniProtKB.
GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
GO:0051089; P:constitutive protein ectodomain proteolysis; IDA:UniProtKB.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042117; P:monocyte activation; IMP:BHF-UCL.
GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.
GO:0007220; P:Notch receptor processing; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IMP:BHF-UCL.
GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL.
GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
GO:0010820; P:positive regulation of T cell chemotaxis; IMP:BHF-UCL.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0016485; P:protein processing; IEA:Ensembl.
GO:0034612; P:response to tumor necrosis factor; IDA:BHF-UCL.

BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:HGNC.
GO:0016589; C:NURF complex; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0043565; F:sequence-specific DNA binding; IDA:HGNC.
GO:0008134; F:transcription factor binding; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007420; P:brain development; IMP:HGNC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0006338; P:chromatin remodeling; IDA:HGNC.
GO:0016569; P:covalent chromatin modification; IEA:UniProtKB-KW.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:HGNC.
GO:0006355; P:regulation of transcription, DNA-templated; IMP:HGNC.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IMP:HGNC.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

MAZ_HUMAN Myc-associated zinc finger protein
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006369; P:termination of RNA polymerase II transcription; IDA:UniProtKB.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.

RBG1L_HUMAN Rab GTPase-activating protein 1-like
GO:0005769; C:early endosome; IDA:MGI.
GO:0005794; C:Golgi apparatus; IDA:MGI.
GO:0005634; C:nucleus; IDA:MGI.
GO:0005096; F:GTPase activator activity; IDA:MGI.
GO:0017137; F:Rab GTPase binding; IDA:BHF-UCL.
GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO:0032880; P:regulation of protein localization; IDA:MGI.
GO:0031338; P:regulation of vesicle fusion; IBA:GO_Central.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SR1IP_HUMAN Protein SREK1IP1
GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.

TSH1_HUMAN Teashirt homolog 1
GO:0005634; C:nucleus; IBA:GO_Central.
GO:0003682; F:chromatin binding; IBA:GO_Central.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0060023; P:soft palate development; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

TSH2_HUMAN Teashirt homolog 2
GO:0005634; C:nucleus; IBA:GO_Central.
GO:0003682; F:chromatin binding; IBA:GO_Central.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

TSH3_HUMAN Teashirt homolog 3
GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.


FINGER Linkages


#18 GASTR contains 7 proteins

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

HRH2_HUMAN Histamine H2 receptor
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004969; F:histamine receptor activity; TAS:ProtInc.
GO:0048565; P:digestive tract development; IEA:Ensembl.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl.
GO:0048732; P:gland development; IEA:Ensembl.
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0007613; P:memory; IEA:Ensembl.
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:1901998; P:toxin transport; IEA:Ensembl.
GO:0008542; P:visual learning; IEA:Ensembl.

HUNIN_HUMAN Humanin {ECO:0000305}
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0048019; F:receptor antagonist activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; TAS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.
GO:0030595; P:leukocyte chemotaxis; IDA:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

PGH1_HUMAN Prostaglandin G/H synthase 1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
GO:0020037; F:heme binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; TAS:Reactome.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:BHF-UCL.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0006954; P:inflammatory response; IEA:InterPro.
GO:0006629; P:lipid metabolic process; NAS:ProtInc.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.

PGH2_HUMAN Prostaglandin G/H synthase 2
GO:0005901; C:caveola; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005788; C:endoplasmic reticulum lumen; TAS:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0050473; F:arachidonate 15-lipoxygenase activity; TAS:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0020037; F:heme binding; ISS:UniProtKB.
GO:0008289; F:lipid binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; NAS:UniProtKB.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; IEA:Ensembl.
GO:0030282; P:bone mineralization; IEA:Ensembl.
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
GO:0071318; P:cellular response to ATP; IEA:Ensembl.
GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0046697; P:decidualization; IEA:Ensembl.
GO:0007566; P:embryo implantation; IEA:Ensembl.
GO:0042633; P:hair cycle; IEA:Ensembl.
GO:0006954; P:inflammatory response; IEA:Ensembl.
GO:0007612; P:learning; IEA:Ensembl.
GO:0019372; P:lipoxygenase pathway; TAS:Reactome.
GO:0035633; P:maintenance of permeability of blood-brain barrier; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO:0032227; P:negative regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0006769; P:nicotinamide metabolic process; TAS:Reactome.
GO:0030728; P:ovulation; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:BHF-UCL.
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.
GO:0031622; P:positive regulation of fever generation; ISS:BHF-UCL.
GO:0090271; P:positive regulation of fibroblast growth factor production; ISS:BHF-UCL.
GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
GO:0090362; P:positive regulation of platelet-derived growth factor production; ISS:BHF-UCL.
GO:0031394; P:positive regulation of prostaglandin biosynthetic process; NAS:BHF-UCL.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:BHF-UCL.
GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:BHF-UCL.
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0006693; P:prostaglandin metabolic process; TAS:ProtInc.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0050727; P:regulation of inflammatory response; NAS:UniProtKB.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO:0009750; P:response to fructose; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0010226; P:response to lithium ion; IEA:Ensembl.
GO:0010042; P:response to manganese ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

PSA_HUMAN Puromycin-sensitive aminopeptidase
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0004177; F:aminopeptidase activity; EXP:Reactome.
GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
GO:0042277; F:peptide binding; IBA:GO_Central.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
GO:0043171; P:peptide catabolic process; IBA:GO_Central.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.


GASTR Linkages


#19 GLUCOSE contains 8 proteins

AATC_HUMAN Aspartate aminotransferase, cytoplasmic
BioMuta; GOT1;
GeneCards; GOT1;
HGNC; HGNC:4432; GOT1.
MalaCards; GOT1;
ChiTaRS; GOT1; human.
GeneWiki; GOT1;
CleanEx; HS_GOT1;
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005764; C:lysosome; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0031406; F:carboxylic acid binding; IEA:Ensembl.
GO:0042802; F:identical protein binding; IBA:GO_Central.
GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IDA:UniProtKB.
GO:0047801; F:L-cysteine:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:Ensembl.
GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
GO:0006532; P:aspartate biosynthetic process; IBA:GO_Central.
GO:0006533; P:aspartate catabolic process; IDA:UniProtKB.
GO:0006531; P:aspartate metabolic process; ISS:UniProtKB.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0032869; P:cellular response to insulin stimulus; IEP:UniProtKB.
GO:0055089; P:fatty acid homeostasis; IEA:Ensembl.
GO:0006094; P:gluconeogenesis; TAS:Reactome.
GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:Ensembl.
GO:0019550; P:glutamate catabolic process to aspartate; IEA:Ensembl.
GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
GO:0006114; P:glycerol biosynthetic process; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO:0006107; P:oxaloacetate metabolic process; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEP:UniProtKB.

ATS4_HUMAN A disintegrin and metalloproteinase with
GO:0031012; C:extracellular matrix; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; TAS:Reactome.
GO:0008237; F:metallopeptidase activity; TAS:ProtInc.
GO:0008233; F:peptidase activity; TAS:ProtInc.
GO:0002020; F:protease binding; IPI:BHF-UCL.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.
GO:0001501; P:skeletal system development; TAS:ProtInc.

GSK3A_HUMAN Glycogen synthase kinase-3 alpha
GO:0030877; C:beta-catenin destruction complex; TAS:UniProtKB.
GO:0005829; C:cytosol; TAS:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0003214; P:cardiac left ventricle morphogenesis; ISS:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; ISS:BHF-UCL.
GO:0046325; P:negative regulation of glucose import; IMP:BHF-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:1904227; P:negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; IMP:BHF-UCL.
GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO:0032007; P:negative regulation of TOR signaling; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0010905; P:negative regulation of UDP-glucose catabolic process; IC:UniProtKB.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:BHF-UCL.
GO:2000467; P:positive regulation of glycogen (starch) synthase activity; ISS:BHF-UCL.
GO:0045823; P:positive regulation of heart contraction; ISS:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; NAS:BHF-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:BHF-UCL.
GO:1903146; P:regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SDIM1_HUMAN Stress-responsive DNAJB4-interacting membrane protein 1
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0033554; P:cellular response to stress; IEP:UniProtKB.
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO:0051402; P:neuron apoptotic process; IDA:UniProtKB.


GLUCOSE Linkages


#20 HEPARAN contains 2 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

GPC1_HUMAN Secreted glypican-1
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0005796; C:Golgi lumen; TAS:Reactome.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005578; C:proteinaceous extracellular matrix; ISS:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:InterPro.
GO:0043236; F:laminin binding; ISS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
GO:0030203; P:glycosaminoglycan metabolic process; TAS:Reactome.
GO:0030200; P:heparan sulfate proteoglycan catabolic process; IDA:UniProtKB.
GO:0032288; P:myelin assembly; ISS:UniProtKB.
GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0014037; P:Schwann cell differentiation; ISS:UniProtKB.


HEPARAN Linkages


#21 HYPOVENTILATION contains 2 proteins

GDNF_HUMAN Glial cell line-derived neurotrophic factor
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005622; C:intracellular; IEA:GOC.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0008344; P:adult locomotory behavior; TAS:BHF-UCL.
GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO:0048484; P:enteric nervous system development; ISS:UniProtKB.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0001656; P:metanephros development; ISS:UniProtKB.
GO:0048255; P:mRNA stabilization; IDA:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:0001755; P:neural crest cell migration; IDA:MGI.
GO:0031175; P:neuron projection development; IDA:MGI.
GO:0001759; P:organ induction; IEA:Ensembl.
GO:0030432; P:peristalsis; ISS:UniProtKB.
GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO:0045597; P:positive regulation of cell differentiation; IGI:MGI.
GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO:0033603; P:positive regulation of dopamine secretion; TAS:BHF-UCL.
GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0032770; P:positive regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0072107; P:positive regulation of ureteric bud formation; IDA:UniProtKB.
GO:0021784; P:postganglionic parasympathetic fiber development; ISS:UniProtKB.
GO:0001941; P:postsynaptic membrane organization; IEA:Ensembl.
GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0010468; P:regulation of gene expression; IGI:MGI.
GO:0060688; P:regulation of morphogenesis of a branching structure; ISS:UniProtKB.
GO:2000736; P:regulation of stem cell differentiation; TAS:ParkinsonsUK-UCL.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
GO:0060676; P:ureteric bud formation; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


HYPOVENTILATION Linkages


#22 IRON contains 6 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

PGH1_HUMAN Prostaglandin G/H synthase 1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
GO:0020037; F:heme binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; TAS:Reactome.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:BHF-UCL.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0006954; P:inflammatory response; IEA:InterPro.
GO:0006629; P:lipid metabolic process; NAS:ProtInc.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.

PGH2_HUMAN Prostaglandin G/H synthase 2
GO:0005901; C:caveola; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005788; C:endoplasmic reticulum lumen; TAS:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0043234; C:protein complex; IEA:Ensembl.
GO:0050473; F:arachidonate 15-lipoxygenase activity; TAS:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0020037; F:heme binding; ISS:UniProtKB.
GO:0008289; F:lipid binding; IEA:Ensembl.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004601; F:peroxidase activity; NAS:UniProtKB.
GO:0004666; F:prostaglandin-endoperoxide synthase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; IEA:Ensembl.
GO:0030282; P:bone mineralization; IEA:Ensembl.
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
GO:0071318; P:cellular response to ATP; IEA:Ensembl.
GO:0071498; P:cellular response to fluid shear stress; IEA:Ensembl.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO:0019371; P:cyclooxygenase pathway; IDA:BHF-UCL.
GO:0046697; P:decidualization; IEA:Ensembl.
GO:0007566; P:embryo implantation; IEA:Ensembl.
GO:0042633; P:hair cycle; IEA:Ensembl.
GO:0006954; P:inflammatory response; IEA:Ensembl.
GO:0007612; P:learning; IEA:Ensembl.
GO:0019372; P:lipoxygenase pathway; TAS:Reactome.
GO:0035633; P:maintenance of permeability of blood-brain barrier; IEA:Ensembl.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO:0032227; P:negative regulation of synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0006769; P:nicotinamide metabolic process; TAS:Reactome.
GO:0030728; P:ovulation; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:BHF-UCL.
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.
GO:0031622; P:positive regulation of fever generation; ISS:BHF-UCL.
GO:0090271; P:positive regulation of fibroblast growth factor production; ISS:BHF-UCL.
GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl.
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
GO:0090362; P:positive regulation of platelet-derived growth factor production; ISS:BHF-UCL.
GO:0031394; P:positive regulation of prostaglandin biosynthetic process; NAS:BHF-UCL.
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:BHF-UCL.
GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:BHF-UCL.
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO:0006693; P:prostaglandin metabolic process; TAS:ProtInc.
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO:0050727; P:regulation of inflammatory response; NAS:UniProtKB.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0032355; P:response to estradiol; IEA:Ensembl.
GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO:0009750; P:response to fructose; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO:0010226; P:response to lithium ion; IEA:Ensembl.
GO:0010042; P:response to manganese ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:InterPro.
GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.

PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005261; F:cation channel activity; ISS:UniProtKB.
GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro.
GO:0006812; P:cation transport; ISS:UniProtKB.
GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IMP:UniProtKB.
GO:0033625; P:positive regulation of integrin activation; IMP:UniProtKB.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.


IRON Linkages


#23 LACTIC contains 2 proteins

DNM1L_HUMAN Dynamin-1-like protein
GO:0005903; C:brush border; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0030742; F:GTP-dependent protein binding; IDA:ParkinsonsUK-UCL.
GO:0005096; F:GTPase activator activity; IC:ParkinsonsUK-UCL.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0008017; F:microtubule binding; IBA:GO_Central.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0017137; F:Rab GTPase binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IDA:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
GO:0060047; P:heart contraction; IEA:Ensembl.
GO:0048312; P:intracellular distribution of mitochondria; IMP:ParkinsonsUK-UCL.
GO:0061025; P:membrane fusion; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
GO:0090149; P:mitochondrial membrane fission; IDA:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0016559; P:peroxisome fission; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IDA:UniProtKB.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0051259; P:protein oligomerization; IMP:UniProtKB.
GO:1903578; P:regulation of ATP metabolic process; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; IGI:ParkinsonsUK-UCL.
GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.


LACTIC Linkages


#24 LEBER contains 2 proteins

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.


LEBER Linkages


#25 LEUKEMIA contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

SPN90_HUMAN NCK-interacting protein with SH3 domain
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005882; C:intermediate filament; NAS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; NAS:UniProtKB.
GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0006607; P:NLS-bearing protein import into nucleus; TAS:ProtInc.
GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.


LEUKEMIA Linkages


#26 LEWY contains 4 proteins

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

SYUB_HUMAN Beta-synuclein
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0016234; C:inclusion body; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0045202; C:synapse; IEA:Ensembl.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0004859; F:phospholipase inhibitor activity; TAS:ProtInc.
GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO:0042417; P:dopamine metabolic process; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:0050808; P:synapse organization; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


LEWY Linkages


#27 LUNG contains 22 proteins

APOE_HUMAN Apolipoprotein E
GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO:0042627; C:chylomicron; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO:0030425; C:dendrite; NAS:BHF-UCL.
GO:0005769; C:early endosome; TAS:Reactome.
GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
GO:0005783; C:endoplasmic reticulum; IDA:AgBase.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:AgBase.
GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
GO:0034363; C:intermediate-density lipoprotein particle; IDA:BHF-UCL.
GO:0034362; C:low-density lipoprotein particle; IDA:BHF-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; NAS:BHF-UCL.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
GO:0016209; F:antioxidant activity; IDA:BHF-UCL.
GO:0001540; F:beta-amyloid binding; IDA:UniProtKB.
GO:0015485; F:cholesterol binding; IBA:GO_Central.
GO:0017127; F:cholesterol transporter activity; IBA:GO_Central.
GO:0008201; F:heparin binding; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IDA:BHF-UCL.
GO:0008289; F:lipid binding; IDA:UniProtKB.
GO:0005319; F:lipid transporter activity; IDA:BHF-UCL.
GO:0071813; F:lipoprotein particle binding; IEA:Ensembl.
GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
GO:0046911; F:metal chelating activity; IDA:BHF-UCL.
GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL.
GO:0005543; F:phospholipid binding; IDA:BHF-UCL.
GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.
GO:0048156; F:tau protein binding; IPI:BHF-UCL.
GO:0070326; F:very-low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
GO:0097113; P:AMPA glutamate receptor clustering; IDA:Alzheimers_University_of_Toronto.
GO:0048844; P:artery morphogenesis; IEA:Ensembl.
GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO:0019934; P:cGMP-mediated signaling; IDA:BHF-UCL.
GO:0006707; P:cholesterol catabolic process; IBA:GO_Central.
GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL.
GO:0034382; P:chylomicron remnant clearance; IMP:BHF-UCL.
GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.
GO:0055089; P:fatty acid homeostasis; IDA:Alzheimers_University_of_Toronto.
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL.
GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
GO:0034375; P:high-density lipoprotein particle remodeling; IGI:BHF-UCL.
GO:0046907; P:intracellular transport; TAS:UniProtKB.
GO:0010877; P:lipid transport involved in lipid storage; ISS:BHF-UCL.
GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
GO:0042159; P:lipoprotein catabolic process; IBA:GO_Central.
GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
GO:0015909; P:long-chain fatty acid transport; IDA:Alzheimers_University_of_Toronto.
GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
GO:0051651; P:maintenance of location in cell; IEA:Ensembl.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0030195; P:negative regulation of blood coagulation; IDA:BHF-UCL.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:ParkinsonsUK-UCL.
GO:0045541; P:negative regulation of cholesterol biosynthetic process; IDA:BHF-UCL.
GO:0090370; P:negative regulation of cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
GO:0061000; P:negative regulation of dendritic spine development; IDA:Alzheimers_University_of_Toronto.
GO:1902951; P:negative regulation of dendritic spine maintenance; IDA:Alzheimers_University_of_Toronto.
GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:BHF-UCL.
GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
GO:0051055; P:negative regulation of lipid biosynthetic process; IDA:Alzheimers_University_of_Toronto.
GO:1903001; P:negative regulation of lipid transport across blood brain barrier; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
GO:1901215; P:negative regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:1902999; P:negative regulation of phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
GO:1901627; P:negative regulation of postsynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:1901630; P:negative regulation of presynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:0031102; P:neuron projection regeneration; IBA:GO_Central.
GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL.
GO:0097114; P:NMDA glutamate receptor clustering; IDA:Alzheimers_University_of_Toronto.
GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
GO:0044794; P:positive regulation by host of viral process; IMP:AgBase.
GO:1902004; P:positive regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0030828; P:positive regulation of cGMP biosynthetic process; IDA:BHF-UCL.
GO:0010875; P:positive regulation of cholesterol efflux; IDA:Alzheimers_University_of_Toronto.
GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL.
GO:0060999; P:positive regulation of dendritic spine development; IDA:Alzheimers_University_of_Toronto.
GO:1902952; P:positive regulation of dendritic spine maintenance; IDA:Alzheimers_University_of_Toronto.
GO:0046889; P:positive regulation of lipid biosynthetic process; IDA:Alzheimers_University_of_Toronto.
GO:1903002; P:positive regulation of lipid transport across blood brain barrier; IDA:Alzheimers_University_of_Toronto.
GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL.
GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.
GO:1902998; P:positive regulation of neurofibrillary tangle assembly; IDA:Alzheimers_University_of_Toronto.
GO:1901216; P:positive regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
GO:1902995; P:positive regulation of phospholipid efflux; IDA:Alzheimers_University_of_Toronto.
GO:1901628; P:positive regulation of postsynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:1901631; P:positive regulation of presynaptic membrane organization; IDA:Alzheimers_University_of_Toronto.
GO:0017038; P:protein import; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; IDA:BHF-UCL.
GO:0030516; P:regulation of axon extension; TAS:UniProtKB.
GO:1900221; P:regulation of beta-amyloid clearance; IDA:Alzheimers_University_of_Toronto.
GO:0032489; P:regulation of Cdc42 protein signal transduction; IDA:BHF-UCL.
GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO:1901214; P:regulation of neuron death; IDA:Alzheimers_University_of_Toronto.
GO:0048168; P:regulation of neuronal synaptic plasticity; TAS:UniProtKB.
GO:1902947; P:regulation of tau-protein kinase activity; IDA:Alzheimers_University_of_Toronto.
GO:0002021; P:response to dietary excess; IEA:Ensembl.
GO:0000302; P:response to reactive oxygen species; NAS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL.
GO:0007271; P:synaptic transmission, cholinergic; TAS:UniProtKB.
GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL.
GO:0006641; P:triglyceride metabolic process; IDA:BHF-UCL.
GO:0042311; P:vasodilation; IEA:Ensembl.
GO:0034447; P:very-low-density lipoprotein particle clearance; IDA:BHF-UCL.
GO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL.
GO:0019068; P:virion assembly; IMP:AgBase.

ATS4_HUMAN A disintegrin and metalloproteinase with
GO:0031012; C:extracellular matrix; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; TAS:Reactome.
GO:0008237; F:metallopeptidase activity; TAS:ProtInc.
GO:0008233; F:peptidase activity; TAS:ProtInc.
GO:0002020; F:protease binding; IPI:BHF-UCL.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.
GO:0001501; P:skeletal system development; TAS:ProtInc.

BHLH9_HUMAN Protein BHLHb9
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0007611; P:learning or memory; ISS:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.

COL12_HUMAN Collectin-12
GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005534; F:galactose binding; NAS:UniProtKB.
GO:0030169; F:low-density lipoprotein particle binding; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0005044; F:scavenger receptor activity; TAS:UniProtKB.
GO:0008329; F:signaling pattern recognition receptor activity; IDA:UniProtKB.
GO:0009756; P:carbohydrate mediated signaling; NAS:UniProtKB.
GO:0071360; P:cellular response to exogenous dsRNA; IMP:UniProtKB.
GO:0006952; P:defense response; TAS:UniProtKB.
GO:0045087; P:innate immune response; TAS:UniProtKB.
GO:0006910; P:phagocytosis, recognition; IDA:UniProtKB.
GO:0060355; P:positive regulation of cell adhesion molecule production; IMP:UniProtKB.
GO:0051260; P:protein homooligomerization; NAS:UniProtKB.
GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome.
GO:0034138; P:toll-like receptor 3 signaling pathway; IMP:UniProtKB.

DHC24_HUMAN Delta(24)-sterol reductase
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; NAS:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0000246; F:delta24(24-1) sterol reductase activity; IMP:UniProtKB.
GO:0050614; F:delta24-sterol reductase activity; EXP:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IDA:MGI.
GO:0042605; F:peptide antigen binding; IPI:UniProtKB.
GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
GO:0006915; P:apoptotic process; NAS:UniProtKB.
GO:0007050; P:cell cycle arrest; NAS:UniProtKB.
GO:0006695; P:cholesterol biosynthetic process; ISS:UniProtKB.
GO:0033489; P:cholesterol biosynthetic process via desmosterol; TAS:Reactome.
GO:0033490; P:cholesterol biosynthetic process via lathosterol; TAS:Reactome.
GO:0030539; P:male genitalia development; IEA:Ensembl.
GO:0061024; P:membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0055114; P:oxidation-reduction process; IMP:UniProtKB.
GO:0031639; P:plasminogen activation; IEA:Ensembl.
GO:0008104; P:protein localization; IEA:Ensembl.
GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
GO:1901214; P:regulation of neuron death; NAS:UniProtKB.
GO:0009725; P:response to hormone; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEP:UniProtKB.
GO:0043588; P:skin development; ISS:UniProtKB.
GO:0009888; P:tissue development; IMP:UniProtKB.

DKK2_HUMAN Dickkopf-related protein 2
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

DKK4_HUMAN Dickkopf-related protein 4 short form
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0061170; P:negative regulation of hair follicle placode formation; IEA:Ensembl.
GO:0030178; P:negative regulation of Wnt signaling pathway; NAS:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

GDNF_HUMAN Glial cell line-derived neurotrophic factor
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005622; C:intracellular; IEA:GOC.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0008344; P:adult locomotory behavior; TAS:BHF-UCL.
GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO:0048484; P:enteric nervous system development; ISS:UniProtKB.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0001656; P:metanephros development; ISS:UniProtKB.
GO:0048255; P:mRNA stabilization; IDA:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:0001755; P:neural crest cell migration; IDA:MGI.
GO:0031175; P:neuron projection development; IDA:MGI.
GO:0001759; P:organ induction; IEA:Ensembl.
GO:0030432; P:peristalsis; ISS:UniProtKB.
GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO:0045597; P:positive regulation of cell differentiation; IGI:MGI.
GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO:0033603; P:positive regulation of dopamine secretion; TAS:BHF-UCL.
GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0032770; P:positive regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0072107; P:positive regulation of ureteric bud formation; IDA:UniProtKB.
GO:0021784; P:postganglionic parasympathetic fiber development; ISS:UniProtKB.
GO:0001941; P:postsynaptic membrane organization; IEA:Ensembl.
GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0010468; P:regulation of gene expression; IGI:MGI.
GO:0060688; P:regulation of morphogenesis of a branching structure; ISS:UniProtKB.
GO:2000736; P:regulation of stem cell differentiation; TAS:ParkinsonsUK-UCL.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
GO:0060676; P:ureteric bud formation; IEA:Ensembl.

GPR3_HUMAN G-protein coupled receptor 3
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

OLR1_HUMAN Oxidized low-density lipoprotein receptor 1,
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; TAS:ProtInc.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO:0005041; F:low-density lipoprotein receptor activity; IEA:Ensembl.
GO:0008015; P:blood circulation; TAS:ProtInc.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0050900; P:leukocyte migration; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.

PREP_HUMAN Presequence protease, mitochondrial
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0006508; P:proteolysis; IMP:UniProtKB.

PSA_HUMAN Puromycin-sensitive aminopeptidase
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0004177; F:aminopeptidase activity; EXP:Reactome.
GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
GO:0042277; F:peptide binding; IBA:GO_Central.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
GO:0043171; P:peptide catabolic process; IBA:GO_Central.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.

SPN90_HUMAN NCK-interacting protein with SH3 domain
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005882; C:intermediate filament; NAS:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; NAS:UniProtKB.
GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
GO:0006607; P:NLS-bearing protein import into nucleus; TAS:ProtInc.
GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.

TNR21_HUMAN Tumor necrosis factor receptor superfamily
GO:0030424; C:axon; IEA:Ensembl.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO:0002250; P:adaptive immune response; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO:0001783; P:B cell apoptotic process; ISS:UniProtKB.
GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
GO:0006959; P:humoral immune response; ISS:UniProtKB.
GO:0006955; P:immune response; IBA:GO_Central.
GO:0006954; P:inflammatory response; IBA:GO_Central.
GO:0042552; P:myelination; ISS:UniProtKB.
GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO:2001180; P:negative regulation of interleukin-10 secretion; ISS:UniProtKB.
GO:2000666; P:negative regulation of interleukin-13 secretion; ISS:UniProtKB.
GO:2000663; P:negative regulation of interleukin-5 secretion; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; IMP:UniProtKB.
GO:0042130; P:negative regulation of T cell proliferation; ISS:UniProtKB.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0097252; P:oligodendrocyte apoptotic process; ISS:UniProtKB.
GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.

UBXN4_HUMAN UBX domain-containing protein 4
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.


LUNG Linkages


#28 MAGNESIUM contains 1 protein

CSEN_HUMAN Calsenilin
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0061337; P:cardiac conduction; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.


MAGNESIUM Linkages


#29 MANGANESE contains 2 proteins

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

PREP_HUMAN Presequence protease, mitochondrial
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0006508; P:proteolysis; IMP:UniProtKB.


MANGANESE Linkages


#30 MELANOMA contains 2 proteins

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005798; C:Golgi-associated vesicle; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0097038; C:perinuclear endoplasmic reticulum; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0097197; C:tetraspanin-enriched microdomain; IDA:UniProtKB.
GO:0004175; F:endopeptidase activity; ISS:UniProtKB.
GO:0005178; F:integrin binding; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO:0005102; F:receptor binding; NAS:UniProtKB.
GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
GO:0051089; P:constitutive protein ectodomain proteolysis; IDA:UniProtKB.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042117; P:monocyte activation; IMP:BHF-UCL.
GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.
GO:0007220; P:Notch receptor processing; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IMP:BHF-UCL.
GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL.
GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
GO:0010820; P:positive regulation of T cell chemotaxis; IMP:BHF-UCL.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0016485; P:protein processing; IEA:Ensembl.
GO:0034612; P:response to tumor necrosis factor; IDA:BHF-UCL.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.


MELANOMA Linkages


#31 MEMORY contains 4 proteins

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

NEUG_HUMAN NEUG(55-78)
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0012510; C:trans-Golgi network transport vesicle membrane; IEA:Ensembl.
GO:0005516; F:calmodulin binding; TAS:ProtInc.
GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
GO:0008306; P:associative learning; IEA:Ensembl.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:1900273; P:positive regulation of long-term synaptic potentiation; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0021537; P:telencephalon development; IEA:Ensembl.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


MEMORY Linkages


#32 MITOCHOND contains 13 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

AATC_HUMAN Aspartate aminotransferase, cytoplasmic
BioMuta; GOT1;
GeneCards; GOT1;
HGNC; HGNC:4432; GOT1.
MalaCards; GOT1;
ChiTaRS; GOT1; human.
GeneWiki; GOT1;
CleanEx; HS_GOT1;
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005764; C:lysosome; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0031406; F:carboxylic acid binding; IEA:Ensembl.
GO:0042802; F:identical protein binding; IBA:GO_Central.
GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IDA:UniProtKB.
GO:0047801; F:L-cysteine:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:Ensembl.
GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
GO:0006532; P:aspartate biosynthetic process; IBA:GO_Central.
GO:0006533; P:aspartate catabolic process; IDA:UniProtKB.
GO:0006531; P:aspartate metabolic process; ISS:UniProtKB.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0032869; P:cellular response to insulin stimulus; IEP:UniProtKB.
GO:0055089; P:fatty acid homeostasis; IEA:Ensembl.
GO:0006094; P:gluconeogenesis; TAS:Reactome.
GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:Ensembl.
GO:0019550; P:glutamate catabolic process to aspartate; IEA:Ensembl.
GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
GO:0006114; P:glycerol biosynthetic process; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO:0006107; P:oxaloacetate metabolic process; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEP:UniProtKB.

CASP4_HUMAN Caspase-4 subunit 2
GO:0097169; C:AIM2 inflammasome complex; IBA:GO_Central.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
GO:0005739; C:mitochondrion; IDA:ParkinsonsUK-UCL.
GO:0072559; C:NLRP3 inflammasome complex; IBA:GO_Central.
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:ProtInc.
GO:1904646; P:cellular response to beta-amyloid; IMP:ParkinsonsUK-UCL.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO:0006508; P:proteolysis; TAS:ProtInc.
GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.

DNM1L_HUMAN Dynamin-1-like protein
GO:0005903; C:brush border; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0030742; F:GTP-dependent protein binding; IDA:ParkinsonsUK-UCL.
GO:0005096; F:GTPase activator activity; IC:ParkinsonsUK-UCL.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0008017; F:microtubule binding; IBA:GO_Central.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0017137; F:Rab GTPase binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IDA:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
GO:0060047; P:heart contraction; IEA:Ensembl.
GO:0048312; P:intracellular distribution of mitochondria; IMP:ParkinsonsUK-UCL.
GO:0061025; P:membrane fusion; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
GO:0090149; P:mitochondrial membrane fission; IDA:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0016559; P:peroxisome fission; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IDA:UniProtKB.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0051259; P:protein oligomerization; IMP:UniProtKB.
GO:1903578; P:regulation of ATP metabolic process; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; IGI:ParkinsonsUK-UCL.
GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB.

HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:ProtInc.
GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome.
GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; IEA:UniProtKB-EC.
GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
GO:0006629; P:lipid metabolic process; TAS:ProtInc.
GO:0070901; P:mitochondrial tRNA methylation; TAS:Reactome.
GO:0090646; P:mitochondrial tRNA processing; TAS:Reactome.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

HUNIN_HUMAN Humanin {ECO:0000305}
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0048019; F:receptor antagonist activity; IDA:UniProtKB.
GO:0005102; F:receptor binding; TAS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.
GO:0030595; P:leukocyte chemotaxis; IDA:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

PREP_HUMAN Presequence protease, mitochondrial
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0006508; P:proteolysis; IMP:UniProtKB.

TEFF2_HUMAN Tomoregulin-2
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO:0045720; P:negative regulation of integrin biosynthetic process; IMP:MGI.
GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
GO:0044319; P:wound healing, spreading of cells; IDA:MGI.

TNR21_HUMAN Tumor necrosis factor receptor superfamily
GO:0030424; C:axon; IEA:Ensembl.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO:0002250; P:adaptive immune response; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO:0001783; P:B cell apoptotic process; ISS:UniProtKB.
GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
GO:0006959; P:humoral immune response; ISS:UniProtKB.
GO:0006955; P:immune response; IBA:GO_Central.
GO:0006954; P:inflammatory response; IBA:GO_Central.
GO:0042552; P:myelination; ISS:UniProtKB.
GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO:2001180; P:negative regulation of interleukin-10 secretion; ISS:UniProtKB.
GO:2000666; P:negative regulation of interleukin-13 secretion; ISS:UniProtKB.
GO:2000663; P:negative regulation of interleukin-5 secretion; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; IMP:UniProtKB.
GO:0042130; P:negative regulation of T cell proliferation; ISS:UniProtKB.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0097252; P:oligodendrocyte apoptotic process; ISS:UniProtKB.
GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.


MITOCHOND Linkages


#33 NYSTAGMUS contains 1 protein

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


NYSTAGMUS Linkages


#34 OPTIC contains 5 proteins

DNM1L_HUMAN Dynamin-1-like protein
GO:0005903; C:brush border; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0030742; F:GTP-dependent protein binding; IDA:ParkinsonsUK-UCL.
GO:0005096; F:GTPase activator activity; IC:ParkinsonsUK-UCL.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0008017; F:microtubule binding; IBA:GO_Central.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0017137; F:Rab GTPase binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IDA:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
GO:0060047; P:heart contraction; IEA:Ensembl.
GO:0048312; P:intracellular distribution of mitochondria; IMP:ParkinsonsUK-UCL.
GO:0061025; P:membrane fusion; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
GO:0090149; P:mitochondrial membrane fission; IDA:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0016559; P:peroxisome fission; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IDA:UniProtKB.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0051259; P:protein oligomerization; IMP:UniProtKB.
GO:1903578; P:regulation of ATP metabolic process; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; IGI:ParkinsonsUK-UCL.
GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB.

HMGB1_HUMAN High mobility group protein B1
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000793; C:condensed chromosome; IDA:UniProtKB.
GO:0005769; C:early endosome; IEA:Ensembl.
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000405; F:bubble DNA binding; ISS:AgBase.
GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IEA:Ensembl.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IMP:UniProtKB.
GO:0070182; F:DNA polymerase binding; IDA:UniProtKB.
GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
GO:0016829; F:lyase activity; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.
GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.
GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO:0097100; F:supercoiled DNA binding; ISS:AgBase.
GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0002218; P:activation of innate immune response; IDA:UniProtKB.
GO:0043277; P:apoptotic cell clearance; IDA:UniProtKB.
GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0006284; P:base-excision repair; IEA:Ensembl.
GO:0031497; P:chromatin assembly; IEA:Ensembl.
GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.
GO:0032392; P:DNA geometric change; ISS:AgBase.
GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO:0006265; P:DNA topological change; ISS:UniProtKB.
GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
GO:0001654; P:eye development; IEA:Ensembl.
GO:0006954; P:inflammatory response; IDA:CACAO.
GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0030324; P:lung development; IEA:Ensembl.
GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.
GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl.
GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:CACAO.
GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; IDA:UniProtKB.
GO:0032689; P:negative regulation of interferon-gamma production; IDA:UniProtKB.
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0097350; P:neutrophil clearance; IDA:UniProtKB.
GO:0002270; P:plasmacytoid dendritic cell activation; IEA:Ensembl.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:UniProtKB.
GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
GO:0051106; P:positive regulation of DNA ligation; ISS:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0045819; P:positive regulation of glycogen catabolic process; IEA:Ensembl.
GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO:0050716; P:positive regulation of interleukin-1 secretion; IDA:UniProtKB.
GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB.
GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
GO:0032425; P:positive regulation of mismatch repair; IDA:UniProtKB.
GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
GO:0032072; P:regulation of restriction endodeoxyribonuclease activity; IDA:UniProtKB.
GO:0002840; P:regulation of T cell mediated immune response to tumor cell; ISS:UniProtKB.
GO:0002643; P:regulation of tolerance induction; IDA:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO:0035711; P:T-helper 1 cell activation; IDA:UniProtKB.
GO:0045063; P:T-helper 1 cell differentiation; IMP:UniProtKB.
GO:1990774; P:tumor necrosis factor secretion; IDA:UniProtKB.
GO:0033151; P:V(D)J recombination; IDA:UniProtKB.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


OPTIC Linkages


#35 OVARIAN contains 2 proteins

KLK8_HUMAN Kallikrein-8
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0008219; P:cell death; ISS:UniProtKB.
GO:0043616; P:keratinocyte proliferation; ISS:UniProtKB.
GO:0007613; P:memory; ISS:UniProtKB.
GO:0048681; P:negative regulation of axon regeneration; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
GO:0050807; P:regulation of synapse organization; ISS:UniProtKB.
GO:0009611; P:response to wounding; ISS:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.


OVARIAN Linkages


#36 PALSY contains 1 protein

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


PALSY Linkages


#37 PARKINSON contains 12 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

HRH2_HUMAN Histamine H2 receptor
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004969; F:histamine receptor activity; TAS:ProtInc.
GO:0048565; P:digestive tract development; IEA:Ensembl.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl.
GO:0048732; P:gland development; IEA:Ensembl.
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0007613; P:memory; IEA:Ensembl.
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:1901998; P:toxin transport; IEA:Ensembl.
GO:0008542; P:visual learning; IEA:Ensembl.

NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
GO:0045333; P:cellular respiration; IBA:GO_Central.
GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
GO:0032981; P:mitochondrial respiratory chain complex I assembly; TAS:Reactome.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.

PAWR_HUMAN PRKC apoptosis WT1 regulator protein
GO:0015629; C:actin cytoskeleton; IDA:HPA.
GO:0005884; C:actin filament; IBA:GO_Central.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IDA:UniProtKB.
GO:0043522; F:leucine zipper domain binding; IPI:UniProtKB.
GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO:0042094; P:interleukin-2 biosynthetic process; IEA:Ensembl.
GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005261; F:cation channel activity; ISS:UniProtKB.
GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro.
GO:0006812; P:cation transport; ISS:UniProtKB.
GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IMP:UniProtKB.
GO:0033625; P:positive regulation of integrin activation; IMP:UniProtKB.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

SYUB_HUMAN Beta-synuclein
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0016234; C:inclusion body; IDA:ParkinsonsUK-UCL.
GO:0005739; C:mitochondrion; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0045202; C:synapse; IEA:Ensembl.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0004859; F:phospholipase inhibitor activity; TAS:ProtInc.
GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO:0042417; P:dopamine metabolic process; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:0050808; P:synapse organization; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


PARKINSON Linkages


#38 PICK contains 4 proteins

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

GPC1_HUMAN Secreted glypican-1
GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0005796; C:Golgi lumen; TAS:Reactome.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO:0045121; C:membrane raft; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005578; C:proteinaceous extracellular matrix; ISS:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
GO:0043395; F:heparan sulfate proteoglycan binding; IEA:InterPro.
GO:0043236; F:laminin binding; ISS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
GO:0030203; P:glycosaminoglycan metabolic process; TAS:Reactome.
GO:0030200; P:heparan sulfate proteoglycan catabolic process; IDA:UniProtKB.
GO:0032288; P:myelin assembly; ISS:UniProtKB.
GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0014037; P:Schwann cell differentiation; ISS:UniProtKB.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


PICK Linkages


#39 PROSTATE contains 9 proteins

BACE2_HUMAN Beta-secretase 2
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:UniProtKB.
GO:0001540; F:beta-amyloid binding; IBA:GO_Central.
GO:0050435; P:beta-amyloid metabolic process; IBA:GO_Central.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IMP:UniProtKB.
GO:0016486; P:peptide hormone processing; NAS:UniProtKB.
GO:0030163; P:protein catabolic process; IBA:GO_Central.
GO:0006508; P:proteolysis; NAS:UniProtKB.

DHC24_HUMAN Delta(24)-sterol reductase
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; NAS:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0000246; F:delta24(24-1) sterol reductase activity; IMP:UniProtKB.
GO:0050614; F:delta24-sterol reductase activity; EXP:Reactome.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IDA:MGI.
GO:0042605; F:peptide antigen binding; IPI:UniProtKB.
GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
GO:0006915; P:apoptotic process; NAS:UniProtKB.
GO:0007050; P:cell cycle arrest; NAS:UniProtKB.
GO:0006695; P:cholesterol biosynthetic process; ISS:UniProtKB.
GO:0033489; P:cholesterol biosynthetic process via desmosterol; TAS:Reactome.
GO:0033490; P:cholesterol biosynthetic process via lathosterol; TAS:Reactome.
GO:0030539; P:male genitalia development; IEA:Ensembl.
GO:0061024; P:membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:0055114; P:oxidation-reduction process; IMP:UniProtKB.
GO:0031639; P:plasminogen activation; IEA:Ensembl.
GO:0008104; P:protein localization; IEA:Ensembl.
GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
GO:1901214; P:regulation of neuron death; NAS:UniProtKB.
GO:0009725; P:response to hormone; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEP:UniProtKB.
GO:0043588; P:skin development; ISS:UniProtKB.
GO:0009888; P:tissue development; IMP:UniProtKB.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.

TEFF2_HUMAN Tomoregulin-2
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; IDA:MGI.
GO:0045720; P:negative regulation of integrin biosynthetic process; IMP:MGI.
GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
GO:0044319; P:wound healing, spreading of cells; IDA:MGI.

TNR21_HUMAN Tumor necrosis factor receptor superfamily
GO:0030424; C:axon; IEA:Ensembl.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO:0002250; P:adaptive immune response; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO:0001783; P:B cell apoptotic process; ISS:UniProtKB.
GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
GO:0006959; P:humoral immune response; ISS:UniProtKB.
GO:0006955; P:immune response; IBA:GO_Central.
GO:0006954; P:inflammatory response; IBA:GO_Central.
GO:0042552; P:myelination; ISS:UniProtKB.
GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO:2001180; P:negative regulation of interleukin-10 secretion; ISS:UniProtKB.
GO:2000666; P:negative regulation of interleukin-13 secretion; ISS:UniProtKB.
GO:2000663; P:negative regulation of interleukin-5 secretion; ISS:UniProtKB.
GO:0031642; P:negative regulation of myelination; IMP:UniProtKB.
GO:0042130; P:negative regulation of T cell proliferation; ISS:UniProtKB.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0097252; P:oligodendrocyte apoptotic process; ISS:UniProtKB.
GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.


PROSTATE Linkages


#40 PSYCHIATRIC contains 2 proteins

HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:ProtInc.
GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome.
GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; IEA:UniProtKB-EC.
GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
GO:0006629; P:lipid metabolic process; TAS:ProtInc.
GO:0070901; P:mitochondrial tRNA methylation; TAS:Reactome.
GO:0090646; P:mitochondrial tRNA processing; TAS:Reactome.

HRH2_HUMAN Histamine H2 receptor
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004969; F:histamine receptor activity; TAS:ProtInc.
GO:0048565; P:digestive tract development; IEA:Ensembl.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO:0001698; P:gastrin-induced gastric acid secretion; IEA:Ensembl.
GO:0048732; P:gland development; IEA:Ensembl.
GO:0001697; P:histamine-induced gastric acid secretion; IEA:Ensembl.
GO:0006955; P:immune response; TAS:ProtInc.
GO:0007613; P:memory; IEA:Ensembl.
GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:1901998; P:toxin transport; IEA:Ensembl.
GO:0008542; P:visual learning; IEA:Ensembl.


PSYCHIATRIC Linkages


#41 PYRAMIDAL contains 3 proteins

DOCK3_HUMAN Dedicator of cytokinesis protein 3
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.

NEUG_HUMAN NEUG(55-78)
GO:0030424; C:axon; IEA:Ensembl.
GO:0044327; C:dendritic spine head; IEA:Ensembl.
GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IEA:Ensembl.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0012510; C:trans-Golgi network transport vesicle membrane; IEA:Ensembl.
GO:0005516; F:calmodulin binding; TAS:ProtInc.
GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
GO:0008306; P:associative learning; IEA:Ensembl.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:1900273; P:positive regulation of long-term synaptic potentiation; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0021537; P:telencephalon development; IEA:Ensembl.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.


PYRAMIDAL Linkages


#42 SENSORY contains 1 protein

CAHM1_HUMAN Calcium homeostasis modulator protein 1
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO:0005227; F:calcium activated cation channel activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
GO:0005244; F:voltage-gated ion channel activity; IDA:UniProtKB.
GO:0015867; P:ATP transport; ISS:UniProtKB.
GO:0006812; P:cation transport; IDA:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO:0034765; P:regulation of ion transmembrane transport; IDA:UniProtKB.
GO:0050913; P:sensory perception of bitter taste; ISS:UniProtKB.
GO:0050916; P:sensory perception of sweet taste; ISS:UniProtKB.
GO:0050917; P:sensory perception of umami taste; ISS:UniProtKB.


SENSORY Linkages


#43 SLEEP contains 1 protein

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.


SLEEP Linkages


#44 SULFUR contains 1 protein

AATC_HUMAN Aspartate aminotransferase, cytoplasmic
BioMuta; GOT1;
GeneCards; GOT1;
HGNC; HGNC:4432; GOT1.
MalaCards; GOT1;
ChiTaRS; GOT1; human.
GeneWiki; GOT1;
CleanEx; HS_GOT1;
GO:0043679; C:axon terminus; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IBA:GO_Central.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005764; C:lysosome; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0031406; F:carboxylic acid binding; IEA:Ensembl.
GO:0042802; F:identical protein binding; IBA:GO_Central.
GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; IDA:UniProtKB.
GO:0047801; F:L-cysteine:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:Ensembl.
GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
GO:0006532; P:aspartate biosynthetic process; IBA:GO_Central.
GO:0006533; P:aspartate catabolic process; IDA:UniProtKB.
GO:0006531; P:aspartate metabolic process; ISS:UniProtKB.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0032869; P:cellular response to insulin stimulus; IEP:UniProtKB.
GO:0055089; P:fatty acid homeostasis; IEA:Ensembl.
GO:0006094; P:gluconeogenesis; TAS:Reactome.
GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:Ensembl.
GO:0019550; P:glutamate catabolic process to aspartate; IEA:Ensembl.
GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
GO:0006114; P:glycerol biosynthetic process; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO:0006107; P:oxaloacetate metabolic process; IEA:Ensembl.
GO:0051384; P:response to glucocorticoid; IEP:UniProtKB.


SULFUR Linkages


#45 TAU contains 17 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1,
GO:0030424; C:axon; ISS:UniProtKB.
GO:0043292; C:contractile fiber; ISS:UniProtKB.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0043197; C:dendritic spine; ISS:UniProtKB.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045296; F:cadherin binding; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0016534; F:cyclin-dependent protein kinase 5 activator activity; IEA:Ensembl.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.
GO:0007411; P:axon guidance; ISS:UniProtKB.
GO:0007413; P:axonal fasciculation; ISS:UniProtKB.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0021549; P:cerebellum development; IEA:Ensembl.
GO:0009790; P:embryo development; IEA:Ensembl.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0007158; P:neuron cell-cell adhesion; ISS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.
GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

DOCK3_HUMAN Dedicator of cytokinesis protein 3
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

GSK3A_HUMAN Glycogen synthase kinase-3 alpha
GO:0030877; C:beta-catenin destruction complex; TAS:UniProtKB.
GO:0005829; C:cytosol; TAS:BHF-UCL.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB.
GO:0003214; P:cardiac left ventricle morphogenesis; ISS:BHF-UCL.
GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.
GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; ISS:BHF-UCL.
GO:0046325; P:negative regulation of glucose import; IMP:BHF-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:1904227; P:negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; IMP:BHF-UCL.
GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.
GO:0032007; P:negative regulation of TOR signaling; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0010905; P:negative regulation of UDP-glucose catabolic process; IC:UniProtKB.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:BHF-UCL.
GO:2000467; P:positive regulation of glycogen (starch) synthase activity; ISS:BHF-UCL.
GO:0045823; P:positive regulation of heart contraction; ISS:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; NAS:BHF-UCL.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:BHF-UCL.
GO:1903146; P:regulation of mitophagy; IMP:ParkinsonsUK-UCL.
GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

PCSK1_HUMAN Big LEN
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0030141; C:secretory granule; IEA:Ensembl.
GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO:0016486; P:peptide hormone processing; IEA:Ensembl.
GO:0009409; P:response to cold; IEA:Ensembl.
GO:0002021; P:response to dietary excess; IEA:Ensembl.

PSA_HUMAN Puromycin-sensitive aminopeptidase
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0004177; F:aminopeptidase activity; EXP:Reactome.
GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
GO:0042277; F:peptide binding; IBA:GO_Central.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
GO:0043171; P:peptide catabolic process; IBA:GO_Central.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.

PSN1_HUMAN Presenilin-1 CTF12
GO:0016235; C:aggresome; IDA:UniProtKB.
GO:0030424; C:axon; IEA:Ensembl.
GO:0030054; C:cell junction; IDA:HPA.
GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070765; C:gamma-secretase complex; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; IDA:HGNC.
GO:0000776; C:kinetochore; IDA:UniProtKB.
GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO:0016020; C:membrane; IDA:MGI.
GO:0045121; C:membrane raft; IDA:UniProtKB.
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0031965; C:nuclear membrane; IDA:UniProtKB.
GO:0005640; C:nuclear outer membrane; IDA:MGI.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098793; C:presynapse; IEA:GOC.
GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
GO:0005790; C:smooth endoplasmic reticulum; IDA:UniProtKB.
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.
GO:0045296; F:cadherin binding; IBA:GO_Central.
GO:0005262; F:calcium channel activity; IMP:UniProtKB.
GO:0004175; F:endopeptidase activity; IDA:MGI.
GO:0030165; F:PDZ domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO:0034205; P:beta-amyloid formation; IEA:Ensembl.
GO:0001568; P:blood vessel development; IEA:Ensembl.
GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO:0001708; P:cell fate specification; IEA:Ensembl.
GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO:0015871; P:choline transport; IEA:Ensembl.
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IGI:UniProtKB.
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO:0001947; P:heart looping; IEA:Ensembl.
GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
GO:0007613; P:memory; IEA:Ensembl.
GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO:0003407; P:neural retina development; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO:0048666; P:neuron development; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0007220; P:Notch receptor processing; TAS:HGNC.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO:0060999; P:positive regulation of dendritic spine development; IMP:CACAO.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:CACAO.
GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO:0016485; P:protein processing; IDA:HGNC.
GO:0015031; P:protein transport; IEA:Ensembl.
GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0016337; P:single organismal cell-cell adhesion; IMP:MGI.
GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO:0001756; P:somitogenesis; IEA:Ensembl.
GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO:0048538; P:thymus development; IEA:Ensembl.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UBB_HUMAN Ubiquitin
PDB; 5GO7; X-ray; 1.80 A; A=1-76.
PDB; 5GO8; X-ray; 2.21 A; A=1-76.
PDB; 5GOB; X-ray; 1.15 A; A=1-76.
PDB; 5GOC; X-ray; 1.73 A; A=1-76.
PDB; 5GOD; X-ray; 1.15 A; A/B=1-76.
PDB; 5GOG; X-ray; 1.98 A; A=1-76.
PDB; 5GOH; X-ray; 1.95 A; A=1-76.
PDB; 5GOI; X-ray; 1.59 A; A/B=1-76.
PDB; 5GOJ; X-ray; 1.55 A; A=1-76.
PDB; 5GOK; X-ray; 1.84 A; A=1-76.
PDBsum; 5GO7;
PDBsum; 5GO8;
PDBsum; 5GOB;
PDBsum; 5GOC;
PDBsum; 5GOD;
PDBsum; 5GOG;
PDBsum; 5GOH;
PDBsum; 5GOI;
PDBsum; 5GOJ;
PDBsum; 5GOK;
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0010008; C:endosome membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0043025; C:neuronal cell body; IDA:MGI.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0000187; P:activation of MAPK activity; TAS:Reactome.
GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0042769; P:DNA damage response, detection of DNA damage; TAS:Reactome.
GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
GO:0016197; P:endosomal transport; TAS:Reactome.
GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0042276; P:error-prone translesion synthesis; TAS:Reactome.
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0070911; P:global genome nucleotide-excision repair; TAS:Reactome.
GO:0005978; P:glycogen biosynthetic process; TAS:Reactome.
GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; TAS:Reactome.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0036297; P:interstrand cross-link repair; TAS:Reactome.
GO:0075733; P:intracellular transport of virus; TAS:Reactome.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0007254; P:JNK cascade; TAS:Reactome.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0047497; P:mitochondrion transport along microtubule; IDA:MGI.
GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome.
GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome.
GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; TAS:Reactome.
GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.
GO:0000715; P:nucleotide-excision repair, DNA damage recognition; TAS:Reactome.
GO:0000717; P:nucleotide-excision repair, DNA duplex unwinding; TAS:Reactome.
GO:0006297; P:nucleotide-excision repair, DNA gap filling; TAS:Reactome.
GO:0033683; P:nucleotide-excision repair, DNA incision; TAS:Reactome.
GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; TAS:Reactome.
GO:0006294; P:nucleotide-excision repair, preincision complex assembly; TAS:Reactome.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome.
GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; TAS:Reactome.
GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IDA:MGI.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.
GO:1902527; P:positive regulation of protein monoubiquitination; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0051881; P:regulation of mitochondrial membrane potential; IDA:MGI.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:0010939; P:regulation of necrotic cell death; TAS:Reactome.
GO:1901214; P:regulation of neuron death; IDA:MGI.
GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:MGI.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome.
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
GO:0032479; P:regulation of type I interferon production; TAS:Reactome.
GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.
GO:0019985; P:translesion synthesis; TAS:Reactome.
GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
GO:0019058; P:viral life cycle; TAS:Reactome.
GO:0019068; P:virion assembly; TAS:Reactome.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.
GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.


TAU Linkages


#46 THYROID contains 2 proteins

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

SORL_HUMAN Sortilin-related receptor
GO:0005769; C:early endosome; IDA:Alzheimers_University_of_Toronto.
GO:0005783; C:endoplasmic reticulum; IDA:Alzheimers_University_of_Toronto.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0031985; C:Golgi cisterna; IDA:Alzheimers_University_of_Toronto.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0055037; C:recycling endosome; IMP:Alzheimers_University_of_Toronto.
GO:0005802; C:trans-Golgi network; IDA:Alzheimers_University_of_Toronto.
GO:0030306; F:ADP-ribosylation factor binding; IPI:Alzheimers_University_of_Toronto.
GO:0001540; F:beta-amyloid binding; IDA:Alzheimers_University_of_Toronto.
GO:0030169; F:low-density lipoprotein particle binding; IPI:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
GO:1902960; P:negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto.
GO:0043407; P:negative regulation of MAP kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902963; P:negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; IMP:Alzheimers_University_of_Toronto.
GO:1902997; P:negative regulation of neurofibrillary tangle assembly; ISS:Alzheimers_University_of_Toronto.
GO:0050768; P:negative regulation of neurogenesis; ISS:Alzheimers_University_of_Toronto.
GO:1901215; P:negative regulation of neuron death; ISS:Alzheimers_University_of_Toronto.
GO:0032091; P:negative regulation of protein binding; IDA:Alzheimers_University_of_Toronto.
GO:0032460; P:negative regulation of protein oligomerization; IMP:Alzheimers_University_of_Toronto.
GO:1902948; P:negative regulation of tau-protein kinase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902771; P:positive regulation of choline O-acetyltransferase activity; ISS:Alzheimers_University_of_Toronto.
GO:1902955; P:positive regulation of early endosome to recycling endosome transport; IMP:Alzheimers_University_of_Toronto.
GO:2001137; P:positive regulation of endocytic recycling; IMP:Alzheimers_University_of_Toronto.
GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; IMP:Alzheimers_University_of_Toronto.
GO:0045732; P:positive regulation of protein catabolic process; IDA:Alzheimers_University_of_Toronto.
GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:Alzheimers_University_of_Toronto.
GO:1902966; P:positive regulation of protein localization to early endosome; IMP:Alzheimers_University_of_Toronto.
GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:Alzheimers_University_of_Toronto.
GO:0051604; P:protein maturation; IDA:Alzheimers_University_of_Toronto.
GO:0045053; P:protein retention in Golgi apparatus; IDA:Alzheimers_University_of_Toronto.
GO:0006605; P:protein targeting; IMP:UniProtKB.
GO:0000042; P:protein targeting to Golgi; IDA:Alzheimers_University_of_Toronto.
GO:0006622; P:protein targeting to lysosome; IDA:Alzheimers_University_of_Toronto.
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
GO:0014910; P:regulation of smooth muscle cell migration; IDA:UniProtKB.


THYROID Linkages


#47 TREMOR contains 3 proteins

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


TREMOR Linkages


#48 UBIQUITIN contains 19 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1,
GO:0030424; C:axon; ISS:UniProtKB.
GO:0043292; C:contractile fiber; ISS:UniProtKB.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0043197; C:dendritic spine; ISS:UniProtKB.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045296; F:cadherin binding; ISS:UniProtKB.
GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO:0016534; F:cyclin-dependent protein kinase 5 activator activity; IEA:Ensembl.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.
GO:0007411; P:axon guidance; ISS:UniProtKB.
GO:0007413; P:axonal fasciculation; ISS:UniProtKB.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0021549; P:cerebellum development; IEA:Ensembl.
GO:0009790; P:embryo development; IEA:Ensembl.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0007158; P:neuron cell-cell adhesion; ISS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.
GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.

CDK5_HUMAN Cyclin-dependent-like kinase 5
GO:0030424; C:axon; ISS:UniProtKB.
GO:0030054; C:cell junction; IDA:HPA.
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:Ensembl.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; IEA:Ensembl.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0030175; C:filopodium; IEA:Ensembl.
GO:0030426; C:growth cone; ISS:UniProtKB.
GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISS:UniProtKB.
GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0014069; C:postsynaptic density; ISS:UniProtKB.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0098793; C:presynapse; IEA:GOC.
GO:0030549; F:acetylcholine receptor activator activity; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:Reactome.
GO:0005176; F:ErbB-2 class receptor binding; ISS:UniProtKB.
GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
GO:0016301; F:kinase activity; ISS:UniProtKB.
GO:0004672; F:protein kinase activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0048675; P:axon extension; TAS:UniProtKB.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0070509; P:calcium ion import; IEA:Ensembl.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO:0021697; P:cerebellar cortex formation; IEA:Ensembl.
GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB.
GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0021766; P:hippocampus development; IEA:Ensembl.
GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO:0045861; P:negative regulation of proteolysis; IMP:ParkinsonsUK-UCL.
GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT.
GO:0051402; P:neuron apoptotic process; TAS:UniProtKB.
GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO:0001764; P:neuron migration; TAS:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
GO:0048709; P:oligodendrocyte differentiation; IDA:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0016310; P:phosphorylation; IDA:DFLAT.
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; TAS:UniProtKB.
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO:0035418; P:protein localization to synapse; IEA:Ensembl.
GO:0032801; P:receptor catabolic process; IEA:Ensembl.
GO:0043113; P:receptor clustering; IEA:Ensembl.
GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.
GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
GO:1903421; P:regulation of synaptic vesicle recycling; NAS:ParkinsonsUK-UCL.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO:0014044; P:Schwann cell development; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO:0007416; P:synapse assembly; TAS:UniProtKB.
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; TAS:UniProtKB.
GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
GO:0008542; P:visual learning; IEA:Ensembl.

DNM1L_HUMAN Dynamin-1-like protein
GO:0005903; C:brush border; IEA:Ensembl.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; TAS:ParkinsonsUK-UCL.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005874; C:microtubule; IDA:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0030742; F:GTP-dependent protein binding; IDA:ParkinsonsUK-UCL.
GO:0005096; F:GTPase activator activity; IC:ParkinsonsUK-UCL.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0008017; F:microtubule binding; IBA:GO_Central.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0017137; F:Rab GTPase binding; IDA:ParkinsonsUK-UCL.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IDA:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
GO:0060047; P:heart contraction; IEA:Ensembl.
GO:0048312; P:intracellular distribution of mitochondria; IMP:ParkinsonsUK-UCL.
GO:0061025; P:membrane fusion; IDA:UniProtKB.
GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
GO:0090149; P:mitochondrial membrane fission; IDA:UniProtKB.
GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
GO:0007005; P:mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:0070266; P:necroptotic process; IMP:UniProtKB.
GO:0016559; P:peroxisome fission; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IMP:ParkinsonsUK-UCL.
GO:0050714; P:positive regulation of protein secretion; IDA:UniProtKB.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
GO:0051259; P:protein oligomerization; IMP:UniProtKB.
GO:1903578; P:regulation of ATP metabolic process; IEA:Ensembl.
GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
GO:1903146; P:regulation of mitophagy; IGI:ParkinsonsUK-UCL.
GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB.

E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005840; C:ribosome; TAS:AgBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003725; F:double-stranded RNA binding; IDA:MGI.
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IMP:UniProtKB.
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0019888; F:protein phosphatase regulator activity; TAS:ProtInc.
GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0000186; P:activation of MAPKK activity; IMP:UniProtKB.
GO:0034198; P:cellular response to amino acid starvation; IMP:UniProtKB.
GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO:0030683; P:evasion or tolerance by virus of host immune response; TAS:Reactome.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
GO:0033689; P:negative regulation of osteoblast proliferation; IMP:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0032722; P:positive regulation of chemokine production; ISS:UniProtKB.
GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO:1902036; P:regulation of hematopoietic stem cell differentiation; ISS:UniProtKB.
GO:1902033; P:regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0009636; P:response to toxic substance; IEA:InterPro.
GO:0009615; P:response to virus; IMP:UniProtKB.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006412; P:translation; IEA:Ensembl.

FLNB_HUMAN Filamin-B
GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0005903; C:brush border; IEA:Ensembl.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0001725; C:stress fiber; IEA:Ensembl.
GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; NAS:UniProtKB.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:ProtInc.
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl.
GO:0003334; P:keratinocyte development; IEA:Ensembl.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.

GSK3B_HUMAN Glycogen synthase kinase-3 beta
GO:0030877; C:beta-catenin destruction complex; IDA:UniProtKB.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0030426; C:growth cone; IEA:Ensembl.
GO:0030529; C:intracellular ribonucleoprotein complex; IEA:Ensembl.
GO:0005739; C:mitochondrion; IEA:GOC.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:1990909; C:Wnt signalosome; TAS:ParkinsonsUK-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.
GO:0016301; F:kinase activity; IDA:UniProtKB.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.
GO:0002039; F:p53 binding; IDA:MGI.
GO:0002020; F:protease binding; IPI:ParkinsonsUK-UCL.
GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.
GO:0004672; F:protein kinase activity; TAS:ParkinsonsUK-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:UniProtKB.
GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO:0007409; P:axonogenesis; IEA:Ensembl.
GO:1904885; P:beta-catenin destruction complex assembly; TAS:Reactome.
GO:1904886; P:beta-catenin destruction complex disassembly; TAS:Reactome.
GO:0060070; P:canonical Wnt signaling pathway; IC:UniProtKB.
GO:0044337; P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process; IEA:Ensembl.
GO:0016477; P:cell migration; IEA:Ensembl.
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO:0036016; P:cellular response to interleukin-3; ISS:UniProtKB.
GO:0099565; P:chemical synaptic transmission, postsynaptic; NAS:ParkinsonsUK-UCL.
GO:0007623; P:circadian rhythm; ISS:UniProtKB.
GO:0007212; P:dopamine receptor signaling pathway; NAS:ParkinsonsUK-UCL.
GO:0001837; P:epithelial to mesenchymal transition; IMP:UniProtKB.
GO:0006983; P:ER overload response; IDA:MGI.
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO:0005977; P:glycogen metabolic process; IDA:BHF-UCL.
GO:0021766; P:hippocampus development; IMP:BHF-UCL.
GO:0044027; P:hypermethylation of CpG island; IEA:Ensembl.
GO:0035556; P:intracellular signal transduction; TAS:ParkinsonsUK-UCL.
GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:UniProtKB.
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO:1904339; P:negative regulation of dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.
GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.
GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:UniProtKB.
GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
GO:0031333; P:negative regulation of protein complex assembly; IMP:BHF-UCL.
GO:1900181; P:negative regulation of protein localization to nucleus; ISS:BHF-UCL.
GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO:0010822; P:positive regulation of mitochondrion organization; IMP:ParkinsonsUK-UCL.
GO:1901216; P:positive regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IC:ParkinsonsUK-UCL.
GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
GO:0045732; P:positive regulation of protein catabolic process; IC:BHF-UCL.
GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
GO:0046827; P:positive regulation of protein export from nucleus; IDA:MGI.
GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0006611; P:protein export from nucleus; IEA:Ensembl.
GO:0035372; P:protein localization to microtubule; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO:1900034; P:regulation of cellular response to heat; TAS:Reactome.
GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
GO:0071109; P:superior temporal gyrus development; IMP:BHF-UCL.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain
GO:0034704; C:calcium channel complex; IEA:Ensembl.
GO:0005783; C:endoplasmic reticulum; IDA:ParkinsonsUK-UCL.
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO:1990037; C:Lewy body core; IDA:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0044325; F:ion channel binding; IPI:ParkinsonsUK-UCL.
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IDA:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL.
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IGI:ParkinsonsUK-UCL.
GO:0036499; P:PERK-mediated unfolded protein response; TAS:Reactome.
GO:1903071; P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO:0031396; P:regulation of protein ubiquitination; IEA:Ensembl.
GO:0034976; P:response to endoplasmic reticulum stress; TAS:ParkinsonsUK-UCL.
GO:0006986; P:response to unfolded protein; IEP:UniProtKB.
GO:0030970; P:retrograde protein transport, ER to cytosol; IMP:ParkinsonsUK-UCL.
GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.

KC1D_HUMAN Casein kinase I isoform delta
GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
GO:0005813; C:centrosome; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:GOC.
GO:0043005; C:neuron projection; IEA:Ensembl.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005819; C:spindle; IDA:UniProtKB.
GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL.
GO:0001948; F:glycoprotein binding; IEA:Ensembl.
GO:0042277; F:peptide binding; IEA:Ensembl.
GO:0004672; F:protein kinase activity; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:ParkinsonsUK-UCL.
GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0048208; P:COPII vesicle coating; TAS:Reactome.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0006897; P:endocytosis; IBA:GO_Central.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0007030; P:Golgi organization; IMP:SYSCILIA_CCNET.
GO:0007020; P:microtubule nucleation; IMP:SYSCILIA_CCNET.
GO:1905515; P:non-motile cilium assembly; IMP:SYSCILIA_CCNET.
GO:0018105; P:peptidyl-serine phosphorylation; IDA:ParkinsonsUK-UCL.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO:1905426; P:positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; IC:ParkinsonsUK-UCL.
GO:0071539; P:protein localization to centrosome; IMP:SYSCILIA_CCNET.
GO:0061512; P:protein localization to cilium; IMP:SYSCILIA_CCNET.
GO:0034067; P:protein localization to Golgi apparatus; IMP:SYSCILIA_CCNET.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO:0006364; P:rRNA processing; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0051225; P:spindle assembly; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

LRP8_HUMAN Low-density lipoprotein receptor-related protein 8
GO:0030424; C:axon; IEA:Ensembl.
GO:0005901; C:caveola; IDA:BHF-UCL.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IC:UniProtKB.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005875; C:microtubule associated complex; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0034185; F:apolipoprotein binding; IC:BHF-UCL.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO:0005041; F:low-density lipoprotein receptor activity; TAS:Reactome.
GO:0038025; F:reelin receptor activity; ISS:BHF-UCL.
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
GO:0030229; F:very-low-density lipoprotein particle receptor activity; IDA:BHF-UCL.
GO:0021541; P:ammon gyrus development; ISS:BHF-UCL.
GO:0071397; P:cellular response to cholesterol; IEA:Ensembl.
GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
GO:0006897; P:endocytosis; IDA:UniProtKB.
GO:0006629; P:lipid metabolic process; NAS:UniProtKB.
GO:0050804; P:modulation of synaptic transmission; ISS:BHF-UCL.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
GO:0032793; P:positive regulation of CREB transcription factor activity; ISS:BHF-UCL.
GO:1900006; P:positive regulation of dendrite development; ISS:BHF-UCL.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:BHF-UCL.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:BHF-UCL.
GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISS:BHF-UCL.
GO:0006508; P:proteolysis; NAS:UniProtKB.
GO:0038026; P:reelin-mediated signaling pathway; ISS:BHF-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0001523; P:retinoid metabolic process; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.

MARK1_HUMAN Serine/threonine-protein kinase MARK1
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005856; C:cytoskeleton; ISS:UniProtKB.
GO:0015630; C:microtubule cytoskeleton; TAS:ProtInc.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0070300; F:phosphatidic acid binding; IDA:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
GO:0001786; F:phosphatidylserine binding; IDA:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO:0030010; P:establishment of cell polarity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
GO:0001764; P:neuron migration; ISS:UniProtKB.
GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0008375; F:acetylglucosaminyltransferase activity; TAS:ProtInc.
GO:0008047; F:enzyme activator activity; IDA:BHF-UCL.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
GO:0097363; F:protein O-GlcNAc transferase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO:0080182; P:histone H3-K4 trimethylation; IMP:UniProtKB.
GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB.
GO:0030854; P:positive regulation of granulocyte differentiation; IMP:BHF-UCL.
GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.
GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB.
GO:0090526; P:regulation of gluconeogenesis involved in cellular glucose homeostasis; ISS:UniProtKB.
GO:0006110; P:regulation of glycolytic process; IDA:UniProtKB.
GO:0046626; P:regulation of insulin receptor signaling pathway; IDA:UniProtKB.
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB.
GO:0032868; P:response to insulin; IDA:UniProtKB.
GO:0007584; P:response to nutrient; TAS:ProtInc.
GO:0007165; P:signal transduction; TAS:ProtInc.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SYUA_HUMAN Alpha-synuclein
GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005576; C:extracellular region; IDA:ParkinsonsUK-UCL.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0043205; C:fibril; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005764; C:lysosome; TAS:ParkinsonsUK-UCL.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005739; C:mitochondrion; TAS:ParkinsonsUK-UCL.
GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0098794; C:postsynapse; IEA:GOC.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0043014; F:alpha-tubulin binding; IPI:UniProtKB.
GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0045502; F:dynein binding; IPI:UniProtKB.
GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
GO:0042393; F:histone binding; IDA:UniProtKB.
GO:0030544; F:Hsp70 protein binding; IPI:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0019894; F:kinesin binding; IPI:UniProtKB.
GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IDA:ParkinsonsUK-UCL.
GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
GO:0048156; F:tau protein binding; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; TAS:ParkinsonsUK-UCL.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO:0007568; P:aging; IEA:Ensembl.
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO:0034599; P:cellular response to oxidative stress; IC:ParkinsonsUK-UCL.
GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO:0001774; P:microglial cell activation; TAS:ParkinsonsUK-UCL.
GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO:1904715; P:negative regulation of chaperone-mediated autophagy; IMP:ParkinsonsUK-UCL.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Ensembl.
GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; TAS:ParkinsonsUK-UCL.
GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL.
GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ParkinsonsUK-UCL.
GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:ParkinsonsUK-UCL.
GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
GO:1903284; P:positive regulation of glutathione peroxidase activity; IDA:ParkinsonsUK-UCL.
GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IDA:ParkinsonsUK-UCL.
GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
GO:0031648; P:protein destabilization; IDA:UniProtKB.
GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
GO:1905606; P:regulation of presynapse assembly; IGI:ParkinsonsUK-UCL.
GO:1903426; P:regulation of reactive oxygen species biosynthetic process; TAS:ParkinsonsUK-UCL.
GO:1903421; P:regulation of synaptic vesicle recycling; TAS:ParkinsonsUK-UCL.
GO:0042493; P:response to drug; IEA:Ensembl.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
GO:0050808; P:synapse organization; IEA:Ensembl.
GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.

TAU_HUMAN Microtubule-associated protein tau
GO:0030424; C:axon; IDA:UniProtKB.
GO:0005930; C:axoneme; IEA:Ensembl.
GO:0044297; C:cell body; IDA:ParkinsonsUK-UCL.
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030425; C:dendrite; IDA:ParkinsonsUK-UCL.
GO:0030426; C:growth cone; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0097418; C:neurofibrillary tangle; NAS:ParkinsonsUK-UCL.
GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0045298; C:tubulin complex; IDA:UniProtKB.
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL.
GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO:0071813; F:lipoprotein particle binding; IPI:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0017124; F:SH3 domain binding; IPI:UniProtKB.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO:0048675; P:axon extension; IEA:Ensembl.
GO:0048699; P:generation of neurons; NAS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Ensembl.
GO:0032387; P:negative regulation of intracellular transport; IEA:Ensembl.
GO:0001764; P:neuron migration; IEA:Ensembl.
GO:0045773; P:positive regulation of axon extension; IDA:UniProtKB.
GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB.
GO:0010506; P:regulation of autophagy; IGI:MGI.
GO:0031113; P:regulation of microtubule polymerization; NAS:UniProtKB.
GO:0060632; P:regulation of microtubule-based movement; IEA:Ensembl.

UBB_HUMAN Ubiquitin
PDB; 5GO7; X-ray; 1.80 A; A=1-76.
PDB; 5GO8; X-ray; 2.21 A; A=1-76.
PDB; 5GOB; X-ray; 1.15 A; A=1-76.
PDB; 5GOC; X-ray; 1.73 A; A=1-76.
PDB; 5GOD; X-ray; 1.15 A; A/B=1-76.
PDB; 5GOG; X-ray; 1.98 A; A=1-76.
PDB; 5GOH; X-ray; 1.95 A; A=1-76.
PDB; 5GOI; X-ray; 1.59 A; A/B=1-76.
PDB; 5GOJ; X-ray; 1.55 A; A=1-76.
PDB; 5GOK; X-ray; 1.84 A; A=1-76.
PDBsum; 5GO7;
PDBsum; 5GO8;
PDBsum; 5GOB;
PDBsum; 5GOC;
PDBsum; 5GOD;
PDBsum; 5GOG;
PDBsum; 5GOH;
PDBsum; 5GOI;
PDBsum; 5GOJ;
PDBsum; 5GOK;
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0010008; C:endosome membrane; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0043005; C:neuron projection; IDA:MGI.
GO:0043025; C:neuronal cell body; IDA:MGI.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0000187; P:activation of MAPK activity; TAS:Reactome.
GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0042769; P:DNA damage response, detection of DNA damage; TAS:Reactome.
GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
GO:0016197; P:endosomal transport; TAS:Reactome.
GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome.
GO:0070987; P:error-free translesion synthesis; TAS:Reactome.
GO:0042276; P:error-prone translesion synthesis; TAS:Reactome.
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0070911; P:global genome nucleotide-excision repair; TAS:Reactome.
GO:0005978; P:glycogen biosynthetic process; TAS:Reactome.
GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; TAS:Reactome.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0036297; P:interstrand cross-link repair; TAS:Reactome.
GO:0075733; P:intracellular transport of virus; TAS:Reactome.
GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO:0007254; P:JNK cascade; TAS:Reactome.
GO:0016236; P:macroautophagy; TAS:Reactome.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0047497; P:mitochondrion transport along microtubule; IDA:MGI.
GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome.
GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome.
GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; TAS:Reactome.
GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.
GO:0000715; P:nucleotide-excision repair, DNA damage recognition; TAS:Reactome.
GO:0000717; P:nucleotide-excision repair, DNA duplex unwinding; TAS:Reactome.
GO:0006297; P:nucleotide-excision repair, DNA gap filling; TAS:Reactome.
GO:0033683; P:nucleotide-excision repair, DNA incision; TAS:Reactome.
GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; TAS:Reactome.
GO:0006294; P:nucleotide-excision repair, preincision complex assembly; TAS:Reactome.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome.
GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; TAS:Reactome.
GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IDA:MGI.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.
GO:1902527; P:positive regulation of protein monoubiquitination; IMP:ParkinsonsUK-UCL.
GO:0031398; P:positive regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; TAS:Reactome.
GO:0051881; P:regulation of mitochondrial membrane potential; IDA:MGI.
GO:0043488; P:regulation of mRNA stability; TAS:Reactome.
GO:0010939; P:regulation of necrotic cell death; TAS:Reactome.
GO:1901214; P:regulation of neuron death; IDA:MGI.
GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:MGI.
GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome.
GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome.
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
GO:0032479; P:regulation of type I interferon production; TAS:Reactome.
GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.
GO:0019985; P:translesion synthesis; TAS:Reactome.
GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
GO:0019058; P:viral life cycle; TAS:Reactome.
GO:0019068; P:virion assembly; TAS:Reactome.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.
GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; TAS:Reactome.

UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1
GO:1904115; C:axon cytoplasm; IEA:GOC.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Ensembl.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0043209; C:myelin sheath; IEA:Ensembl.
GO:0044306; C:neuron projection terminus; IEA:Ensembl.
GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL.
GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008242; F:omega peptidase activity; IDA:UniProtKB.
GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL.
GO:0007628; P:adult walking behavior; IEA:Ensembl.
GO:0007412; P:axon target recognition; IEA:Ensembl.
GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
GO:0008283; P:cell proliferation; IEA:Ensembl.
GO:0042755; P:eating behavior; IEA:Ensembl.
GO:0048747; P:muscle fiber development; IEA:Ensembl.
GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL.
GO:0016579; P:protein deubiquitination; IDA:UniProtKB.
GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL.
GO:0002931; P:response to ischemia; IEA:Ensembl.
GO:0019233; P:sensory perception of pain; IEA:Ensembl.


UBIQUITIN Linkages


#49 UP-REGULATED contains 4 proteins

GDNF_HUMAN Glial cell line-derived neurotrophic factor
GO:0005576; C:extracellular region; IDA:UniProtKB.
GO:0005622; C:intracellular; IEA:GOC.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO:0005102; F:receptor binding; TAS:ProtInc.
GO:0008344; P:adult locomotory behavior; TAS:BHF-UCL.
GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO:0048484; P:enteric nervous system development; ISS:UniProtKB.
GO:0000165; P:MAPK cascade; TAS:Reactome.
GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0001656; P:metanephros development; ISS:UniProtKB.
GO:0048255; P:mRNA stabilization; IDA:BHF-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
GO:0007399; P:nervous system development; TAS:ProtInc.
GO:0001755; P:neural crest cell migration; IDA:MGI.
GO:0031175; P:neuron projection development; IDA:MGI.
GO:0001759; P:organ induction; IEA:Ensembl.
GO:0030432; P:peristalsis; ISS:UniProtKB.
GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO:0045597; P:positive regulation of cell differentiation; IGI:MGI.
GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO:0033603; P:positive regulation of dopamine secretion; TAS:BHF-UCL.
GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO:0032770; P:positive regulation of monooxygenase activity; IDA:BHF-UCL.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO:0072107; P:positive regulation of ureteric bud formation; IDA:UniProtKB.
GO:0021784; P:postganglionic parasympathetic fiber development; ISS:UniProtKB.
GO:0001941; P:postsynaptic membrane organization; IEA:Ensembl.
GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
GO:0010468; P:regulation of gene expression; IGI:MGI.
GO:0060688; P:regulation of morphogenesis of a branching structure; ISS:UniProtKB.
GO:2000736; P:regulation of stem cell differentiation; TAS:ParkinsonsUK-UCL.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
GO:0060676; P:ureteric bud formation; IEA:Ensembl.

NDRG2_HUMAN Protein NDRG2
GO:0005813; C:centrosome; IDA:HPA.
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005829; C:cytosol; NAS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO:0005815; C:microtubule organizing center; IDA:HPA.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO:0090361; P:regulation of platelet-derived growth factor production; IEA:Ensembl.
GO:0010574; P:regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO:0007165; P:signal transduction; IBA:GO_Central.
GO:0021762; P:substantia nigra development; IEP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.


UP-REGULATED Linkages


#50 ZINC contains 17 proteins

A4_HUMAN C31
GO:0045177; C:apical part of cell; IEA:Ensembl.
GO:0097449; C:astrocyte projection; IEA:Ensembl.
GO:0030424; C:axon; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO:0035253; C:ciliary rootlet; IEA:Ensembl.
GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043198; C:dendritic shaft; IDA:MGI.
GO:0043197; C:dendritic spine; IDA:MGI.
GO:0005768; C:endosome; IDA:UniProtKB.
GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0030134; C:ER to Golgi transport vesicle; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:1990812; C:growth cone filopodium; IEA:Ensembl.
GO:1990761; C:growth cone lamellipodium; IEA:Ensembl.
GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0044304; C:main axon; IEA:Ensembl.
GO:0045121; C:membrane raft; IDA:ParkinsonsUK-UCL.
GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO:0005641; C:nuclear envelope lumen; IDA:Alzheimers_University_of_Toronto.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
GO:0043235; C:receptor complex; IDA:MGI.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0005790; C:smooth endoplasmic reticulum; IEA:GOC.
GO:0051233; C:spindle midzone; IEA:Ensembl.
GO:0045202; C:synapse; IDA:MGI.
GO:0043195; C:terminal bouton; IEA:Ensembl.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0033130; F:acetylcholine receptor binding; IPI:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL.
GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO:0051425; F:PTB domain binding; IPI:BHF-UCL.
GO:0005102; F:receptor binding; IPI:BHF-UCL.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
GO:1990000; P:amyloid fibril formation; IMP:ParkinsonsUK-UCL.
GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO:0008088; P:axo-dendritic transport; ISS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; ISS:UniProtKB.
GO:0007409; P:axonogenesis; ISS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
GO:0009987; P:cellular process; IMP:ParkinsonsUK-UCL.
GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0071874; P:cellular response to norepinephrine stimulus; IEA:Ensembl.
GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO:0048669; P:collateral sprouting in absence of injury; ISS:UniProtKB.
GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO:0016358; P:dendrite development; ISS:UniProtKB.
GO:0006897; P:endocytosis; ISS:UniProtKB.
GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
GO:0030900; P:forebrain development; IEA:Ensembl.
GO:0045087; P:innate immune response; IMP:UniProtKB.
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
GO:0007626; P:locomotory behavior; ISS:UniProtKB.
GO:0007617; P:mating behavior; ISS:UniProtKB.
GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0016322; P:neuron remodeling; ISS:UniProtKB.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
GO:0006417; P:regulation of translation; ISS:UniProtKB.
GO:0010288; P:response to lead ion; IEA:Ensembl.
GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO:0001878; P:response to yeast; IMP:UniProtKB.
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
GO:0001967; P:suckling behavior; IEA:Ensembl.
GO:0051124; P:synaptic growth at neuromuscular junction; IEA:Ensembl.
GO:0008542; P:visual learning; ISS:UniProtKB.

ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005925; C:focal adhesion; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0005798; C:Golgi-associated vesicle; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0097038; C:perinuclear endoplasmic reticulum; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0097197; C:tetraspanin-enriched microdomain; IDA:UniProtKB.
GO:0004175; F:endopeptidase activity; ISS:UniProtKB.
GO:0005178; F:integrin binding; NAS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO:0005102; F:receptor binding; NAS:UniProtKB.
GO:0007267; P:cell-cell signaling; NAS:UniProtKB.
GO:0051089; P:constitutive protein ectodomain proteolysis; IDA:UniProtKB.
GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.
GO:0042117; P:monocyte activation; IMP:BHF-UCL.
GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.
GO:0007220; P:Notch receptor processing; TAS:Reactome.
GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IMP:BHF-UCL.
GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL.
GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
GO:0010820; P:positive regulation of T cell chemotaxis; IMP:BHF-UCL.
GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO:0016485; P:protein processing; IEA:Ensembl.
GO:0034612; P:response to tumor necrosis factor; IDA:BHF-UCL.

ATS4_HUMAN A disintegrin and metalloproteinase with
GO:0031012; C:extracellular matrix; IDA:UniProtKB.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO:0004222; F:metalloendopeptidase activity; TAS:Reactome.
GO:0008237; F:metallopeptidase activity; TAS:ProtInc.
GO:0008233; F:peptidase activity; TAS:ProtInc.
GO:0002020; F:protease binding; IPI:BHF-UCL.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
GO:0006508; P:proteolysis; TAS:ProtInc.
GO:0001501; P:skeletal system development; TAS:ProtInc.

BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF
GO:0044297; C:cell body; IEA:Ensembl.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0030425; C:dendrite; IEA:Ensembl.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:HGNC.
GO:0016589; C:NURF complex; IDA:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO:0043565; F:sequence-specific DNA binding; IDA:HGNC.
GO:0008134; F:transcription factor binding; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007420; P:brain development; IMP:HGNC.
GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO:0006338; P:chromatin remodeling; IDA:HGNC.
GO:0016569; P:covalent chromatin modification; IEA:UniProtKB-KW.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:HGNC.
GO:0006355; P:regulation of transcription, DNA-templated; IMP:HGNC.
GO:0009611; P:response to wounding; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IMP:HGNC.

ECE2_HUMAN Endothelin-converting enzyme 2 region
GO:0030659; C:cytoplasmic vesicle membrane; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0007420; P:brain development; ISS:UniProtKB.
GO:0010002; P:cardioblast differentiation; ISS:UniProtKB.
GO:0007267; P:cell-cell signaling; TAS:UniProtKB.
GO:0007507; P:heart development; ISS:UniProtKB.
GO:0016486; P:peptide hormone processing; IDA:UniProtKB.

FOLH1_HUMAN Glutamate carboxypeptidase 2
GO:0009986; C:cell surface; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO:1904492; F:Ac-Asp-Glu binding; IDA:BHF-UCL.
GO:0016805; F:dipeptidase activity; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004181; F:metallocarboxypeptidase activity; IDA:BHF-UCL.
GO:0008233; F:peptidase activity; NAS:UniProtKB.
GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IDA:BHF-UCL.
GO:0035609; P:C-terminal protein deglutamylation; IDA:BHF-UCL.
GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
GO:0006760; P:folic acid-containing compound metabolic process; IEA:Ensembl.
GO:0006508; P:proteolysis; NAS:UniProtKB.

MAZ_HUMAN Myc-associated zinc finger protein
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB.
GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO:0006369; P:termination of RNA polymerase II transcription; IDA:UniProtKB.
GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.

MT3_HUMAN Metallothionein-3
GO:0097450; C:astrocyte end-foot; IEA:Ensembl.
GO:0030424; C:axon; IEA:Ensembl.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0043197; C:dendritic spine; IEA:Ensembl.
GO:0005615; C:extracellular space; IEA:Ensembl.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005622; C:intracellular; IDA:UniProtKB.
GO:0005874; C:microtubule; IEA:Ensembl.
GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; IEA:Ensembl.
GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO:0005840; C:ribosome; IEA:Ensembl.
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO:0016209; F:antioxidant activity; NAS:UniProtKB.
GO:0046870; F:cadmium ion binding; IDA:UniProtKB.
GO:0005507; F:copper ion binding; IDA:UniProtKB.
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
GO:0008144; F:drug binding; IDA:UniProtKB.
GO:0030295; F:protein kinase activator activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB.
GO:0014002; P:astrocyte development; ISS:UniProtKB.
GO:0007420; P:brain development; IEA:Ensembl.
GO:0055073; P:cadmium ion homeostasis; IDA:UniProtKB.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0044242; P:cellular lipid catabolic process; ISS:UniProtKB.
GO:0006875; P:cellular metal ion homeostasis; NAS:UniProtKB.
GO:0071276; P:cellular response to cadmium ion; IDA:UniProtKB.
GO:0035690; P:cellular response to drug; IDA:UniProtKB.
GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
GO:0071732; P:cellular response to nitric oxide; IDA:UniProtKB.
GO:0034599; P:cellular response to oxidative stress; IEP:UniProtKB.
GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
GO:0006707; P:cholesterol catabolic process; ISS:UniProtKB.
GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
GO:0070371; P:ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0016570; P:histone modification; IMP:UniProtKB.
GO:0033210; P:leptin-mediated signaling pathway; ISS:UniProtKB.
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO:0010507; P:negative regulation of autophagy; ISS:UniProtKB.
GO:0030517; P:negative regulation of axon extension; IDA:UniProtKB.
GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IDA:UniProtKB.
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
GO:2000296; P:negative regulation of hydrogen peroxide catabolic process; IEA:Ensembl.
GO:0060547; P:negative regulation of necrotic cell death; IDA:UniProtKB.
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0051354; P:negative regulation of oxidoreductase activity; IDA:UniProtKB.
GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO:0097214; P:positive regulation of lysosomal membrane permeability; ISS:UniProtKB.
GO:0010940; P:positive regulation of necrotic cell death; IDA:UniProtKB.
GO:2000376; P:positive regulation of oxygen metabolic process; ISS:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IDA:UniProtKB.
GO:0036091; P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IDA:UniProtKB.
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.
GO:0000060; P:protein import into nucleus, translocation; IDA:UniProtKB.
GO:0043491; P:protein kinase B signaling; IDA:UniProtKB.
GO:0050821; P:protein stabilization; IDA:UniProtKB.
GO:0060049; P:regulation of protein glycosylation; ISS:UniProtKB.
GO:0032095; P:regulation of response to food; ISS:UniProtKB.
GO:0019430; P:removal of superoxide radicals; IDA:UniProtKB.
GO:0001666; P:response to hypoxia; IDA:UniProtKB.
GO:0010038; P:response to metal ion; TAS:Reactome.
GO:0006829; P:zinc II ion transport; ISS:UniProtKB.
GO:0055069; P:zinc ion homeostasis; IDA:UniProtKB.

PREP_HUMAN Presequence protease, mitochondrial
GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IDA:HPA.
GO:0008047; F:enzyme activator activity; TAS:ProtInc.
GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0016485; P:protein processing; IBA:GO_Central.
GO:0006508; P:proteolysis; IMP:UniProtKB.

PSA_HUMAN Puromycin-sensitive aminopeptidase
GO:0005829; C:cytosol; TAS:Reactome.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IBA:GO_Central.
GO:0004177; F:aminopeptidase activity; EXP:Reactome.
GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
GO:0042277; F:peptide binding; IBA:GO_Central.
GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
GO:0043171; P:peptide catabolic process; IBA:GO_Central.
GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO:0000209; P:protein polyubiquitination; TAS:Reactome.

RN146_HUMAN E3 ubiquitin-protein ligase RNF146
GO:0005829; C:cytosol; IDA:UniProtKB.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0072572; F:poly-ADP-D-ribose binding; IDA:UniProtKB.
GO:0061630; F:ubiquitin protein ligase activity; TAS:Reactome.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
GO:0016055; P:Wnt signaling pathway; TAS:Reactome.

RN182_HUMAN E3 ubiquitin-protein ligase RNF182
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

SQSTM_HUMAN Sequestosome-1
GO:0016235; C:aggresome; IBA:GO_Central.
GO:0044753; C:amphisome; IDA:ParkinsonsUK-UCL.
GO:0044754; C:autolysosome; IDA:ParkinsonsUK-UCL.
GO:0005776; C:autophagosome; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
GO:0005829; C:cytosol; TAS:UniProtKB.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0016234; C:inclusion body; IDA:UniProtKB.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0016605; C:PML body; IDA:UniProtKB.
GO:0000407; C:pre-autophagosomal structure; IEA:Ensembl.
GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO:0042802; F:identical protein binding; IPI:IntAct.
GO:0019901; F:protein kinase binding; IDA:UniProtKB.
GO:0005080; F:protein kinase C binding; IPI:UniProtKB.
GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030971; F:receptor tyrosine kinase binding; TAS:ProtInc.
GO:0042169; F:SH2 domain binding; IDA:UniProtKB.
GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0006914; P:autophagy; IMP:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0016197; P:endosomal transport; TAS:UniProtKB.
GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB.
GO:0016236; P:macroautophagy; ISS:UniProtKB.
GO:0000422; P:mitophagy; NAS:ParkinsonsUK-UCL.
GO:0098779; P:mitophagy in response to mitochondrial depolarization; IGI:ParkinsonsUK-UCL.
GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome.
GO:0016239; P:positive regulation of macroautophagy; IMP:UniProtKB.
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:UniProtKB.
GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
GO:0008104; P:protein localization; TAS:UniProtKB.
GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO:0010821; P:regulation of mitochondrion organization; NAS:ParkinsonsUK-UCL.
GO:0061635; P:regulation of protein complex stability; IDA:UniProtKB.
GO:0046578; P:regulation of Ras protein signal transduction; NAS:UniProtKB.
GO:0006950; P:response to stress; TAS:UniProtKB.
GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc.

SR1IP_HUMAN Protein SREK1IP1
GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.

TSH1_HUMAN Teashirt homolog 1
GO:0005634; C:nucleus; IBA:GO_Central.
GO:0003682; F:chromatin binding; IBA:GO_Central.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0060023; P:soft palate development; IEA:Ensembl.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

TSH2_HUMAN Teashirt homolog 2
GO:0005634; C:nucleus; IBA:GO_Central.
GO:0003682; F:chromatin binding; IBA:GO_Central.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.

TSH3_HUMAN Teashirt homolog 3
GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003682; F:chromatin binding; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; ISS:UniProtKB.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.


ZINC Linkages