Disease Motifs
Investigating the Biomechanics of Disease
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Parkinson's Disease (PD)

The script picked up 95 proteins with some association with Parkinson's disease, two of which were discarded for being false positives so leaving 93 proteins that are looked here. This work has been done with a database that was downloaded from the EBI on the 7th & 8th of January 2017.

To see the protein sequence analysis on the proteins that are associated with Parkinson's disease click on this link Protein sequence analysis of Parkinson's disease



Preliminary set theory-type analysis of proteins associated with Parkinson's disease
- published paper 2014

Journal of Alzheimers Disease & Parkinsonism

Cancer associated with Parkinson's Disease (Oncological Parkinson's Disease)

Consisting of 41 proteins that have some mention of PD and 'possibly' cancer. Some of these have no polyphorphisms connected with the increased chance of developing a particular disease.

We have some smaller subsets mostly contained within this larger cancer set



Alzheimic Parkinson's Disease

Consisting of 11 proteins that have some mention of Alzheimer's Disease and PD. One of these has no polyphorphisms connected with the increased chance of developing a particular disease.



Alzheimer's disease

There are a total of 96 proteins that seem to have some mention of Alzheimer's disease within the comments section of the protein datasheet. None were excluded. This work was done using a database that was downloaded from the EBI on the 7th & 8th of January 2017.

To see the protein sequence analysis on the proteins that are associated with Alzheimer's disease click on this link Protein sequence analysis of Alzheimer's disease


Proteomic Analysis of the Amyloid Precursor A4 Protein Proteomic Analysis of the Amyloid Precursor A4 Protein

Not published in scientific journal but this paper is available as an e-paper for £3.99 exVAT. This is just a five page article or paper but will help fund my work.




Prion Diseases (CJD FFI and GSS)

Three dimensional structure of HuPrP(90-231 M129 Q212P).  DOI:10.2210/pdb2kun/pdb  2KUN.  Image produced courtesy of RCSB PDB
Human Prion Protein showing amino acid residue 90 to 231 containing the Q212P mutation that is believed to increase the probablity of an individual developing Gerstmann-Sträussler-Scheinker Disease GSS.
Image courtesy of the RCSB PDB
DOI:10.2210/pdb2kun/pdb
Some basic research into Prion diseases such as CJD, GSS and FFI. Largely work done on the prion protein as well as Cystatin-C and Gamma-enolase. The latter two more in regarding CJD.












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