Disease Motifs
Investigating the Biomechanics of Disease
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Parkinson's Disease (PD)

The script picked up 95 proteins with some association with Parkinson's disease, two of which were discarded for being false positives so leaving 93 proteins that are looked here. This work has been done with a database that was downloaded from the EBI on the 7th & 8th of January 2017.

To see the protein sequence analysis on the proteins that are associated with Parkinson's disease click on this link Protein sequence analysis of Parkinson's disease


Published paper 2014
Preliminary set theory-type analysis of proteins associated with Parkinson's disease

OncoPD (Oncological Parkinson's Disease)

Consisting of 32 proteins that have some mention of PD and 'possibly' cancer. Six of these have no polyphorphisms connected with the increased chance of developing a particular disease. There are quite a few false positives in here and work is in progress to reduce the number of these.



Alzheimic Parkinson's Disease

Consisting of 11 proteins that have some mention of Alzheimer's Disease and PD. One of these has no polyphorphisms connected with the increased chance of developing a particular disease.



Alzheimer's disease

There are a total of 96 proteins that seem to have some mention of Alzheimer's disease within the comments section of the protein datasheet. None were excluded. This work was done using a database that was downloaded from the EBI on the 7th & 8th of January 2017.

To see the protein sequence analysis on the proteins that are associated with Alzheimer's disease click on this link Protein sequence analysis of Alzheimer's disease



Prion Diseases (CJD FFI and GSS)

Three dimensional structure of HuPrP(90-231 M129 Q212P).  DOI:10.2210/pdb2kun/pdb  2KUN.  Image produced courtesy of RCSB PDB
Human Prion Protein showing amino acid residue 90 to 231 containing the Q212P mutation that is believed to increase the probablity of an individual developing Gerstmann-Sträussler-Scheinker Disease GSS.
Image courtesy of the RCSB PDB
DOI:10.2210/pdb2kun/pdb
Some basic research into Prion diseases such as CJD, GSS and FFI. Largely work done on the prion protein as well as Cystatin-C and Gamma-enolase. The latter two more in regarding CJD.












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